Detailed view for Smp_177420

Basic information

TDR Targets ID: 284548
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 10.5364 | Length (AA): 116 | MW (Da): 13877 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00992   Troponin

Gene Ontology

Mouse over links to read term descriptions.
GO:0005861   troponin complex  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 111 4uos (A) 68 173 22.00 0.0013 0.16 1.2562 -1.19
1 59 5wsu (C) 792 851 19.00 0.0082 0.02 0.780921 -1.76
2 94 2x3w (C) 127 235 32.00 0.16 0.94 1.08192 -0.54
7 111 4y99 (C) 31 125 34.00 0 0.29 1.18097 -0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132708)

Species Accession Gene Product
Brugia malayi Bm1_35060   Troponin family protein
Brugia malayi Bm1_51735   Troponin I
Caenorhabditis elegans CELE_ZK721.2   Protein UNC-27
Caenorhabditis elegans CELE_T20B3.2   Protein TNI-3
Caenorhabditis elegans CELE_W03F8.1   Protein TNI-4
Drosophila melanogaster Dmel_CG7178   wings up A
Echinococcus granulosus EgrG_000734700   troponin i
Echinococcus multilocularis EmuJ_000734700   troponin i
Homo sapiens ENSG00000129991   troponin I type 3 (cardiac)
Loa Loa (eye worm) LOAG_11825   hypothetical protein
Loa Loa (eye worm) LOAG_08015   hypothetical protein
Loa Loa (eye worm) LOAG_11826   troponin I
Mus musculus ENSMUSG00000035458   troponin I, cardiac 3
Onchocerca volvulus OVOC5747   Troponin I homolog
Schistosoma japonicum Sjp_0115690   IPR001978,Troponin,domain-containing
Schistosoma japonicum Sjp_0026420   Troponin I 4, putative
Schistosoma japonicum Sjp_0071030   expressed protein
Schistosoma mansoni Smp_059170.1   troponin I
Schistosoma mansoni Smp_018250.2   troponin I
Schistosoma mansoni Smp_018250.3   troponin I
Schistosoma mansoni Smp_177420   hypothetical protein
Schistosoma mansoni Smp_059170.2   troponin I
Schmidtea mediterranea mk4.002050.02   Troponin I
Schmidtea mediterranea mk4.000532.11   Troponin I
Schmidtea mediterranea mk4.005568.01  

Essentiality

Smp_177420 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T20B3.2 Caenorhabditis elegans larval lethal wormbase
CELE_T20B3.2 Caenorhabditis elegans sterile wormbase
CELE_W03F8.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_W03F8.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens troponin I type 3 (cardiac) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0105 0.517 0.7953
0.0115 0.5127 0.7979
0.0104 0.3391 0.3391
0.0108 0.517 0.7799
0.0111 0.774 0.774
0.0129 0.739 0.739
0.0109 0.517 0.7954
0.0129 0.2555 0.346
0.0106 0.517 0.7955
0.0118 0.3608 0.803
0.011 0.517 0.7958
0.0122 0.6851 0.6609
0.0105 0.2767 0.2707
0.0129 0.3452 0.6116
0.0118 0.4915 0.7839
0.0106 0.326 0.7888
0.0117 0.5027 0.6393
0.0117 0.5027 0.6393
0.0111 0.3421 0.3416
0.0109 0.517 0.7956
0.0111 0.517 0.7956
0.0116 0.3608 0.803
0.0116 0.354 0.6689
0.0103 0.2634 0.7931
0.011 0.739 0.739
0.0129 0.4079 0.4044
0.0116 0.3465 0.3422
0.0116 0.5162 0.8002
0.0118 0.2783 0.2786
0.0108 0.4431 0.8012
0.0113 0.517 0.796
0.0117 0.5059 0.7936
0.0109 0.3146 0.3146
0.0117 0.5027 0.6393
0.0121 0.517 0.7969
0.0121 0.2529 0.2529
0.0109 0.517 0.7953
0.0104 0.517 0.7799
0.0121 0.2526 0.2516
0.0129 0.4856 0.7799
0.0117 0.5027 0.6393
0.0109 0.4856 0.7799
0.0104 0.517 0.7848
0.0124 0.4937 0.7854
0.0129 0.517 0.7799
0.0115 0.5114 0.7956
0.0129 0.3366 0.3366
0.0116 0.4976 0.788
0.0117 0.5027 0.6393
0.0104 0.3623 0.3623
0.0115 0.5138 0.5617
0.0093 0.2513 0.2513
0.0111 0.3421 0.3416
0.0129 0.2513 0.2513
0.0108 0.2833 0.7955
0.0104 0.3608 0.803
0.0107 0.517 0.7799
0.0117 0.5027 0.6393
0.0129 0.4599 0.4599

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_177420 (Schistosoma mansoni), hypothetical protein
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