Detailed view for Smp_137160

Basic information

TDR Targets ID: 285592
Schistosoma mansoni, mitochondrial solute carrier
Source Database / ID:  GeneDB

pI: 9.0298 | Length (AA): 660 | MW (Da): 74356 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein
PF13833   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005743   mitochondrial inner membrane  
GO:0005509   calcium ion binding  
GO:0005488   binding  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 76 3cs1 (A) 118 192 16.00 0 0.51 0.424852 -1.34
13 304 4p60 (B) 17 308 41.00 0 1 0.921124 -0.77
84 150 1n0y (B) 82 145 25.00 0.033 0.3 0.381915 -0.51
84 154 2m97 (A) 2 69 25.00 0.000067 0.35 0.393976 -0.52
91 250 1k94 (A) 55 212 13.00 0 0.82 0.361124 -0.39
323 605 6gci (A) 12 305 23.00 0.0000044 0.33 0.547188 0.74
493 604 5zfs (A) 41 151 30.00 0.87 0.1 0.309397 0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129669)

Species Accession Gene Product
Candida albicans CaO19.4966   potential mitochondrial carrier protein similar to S. cerevisiae AGC1 (YPR021C) Aspartate-glutamate transporter
Candida albicans CaO19.12431   potential mitochondrial carrier protein similar to S. cerevisiae AGC1 (YPR021C) Aspartate-glutamate transporter
Caenorhabditis elegans CELE_K02F3.2   Protein K02F3.2, isoform B
Dictyostelium discoideum DDB_G0283329   EF-hand domain-containing protein
Drosophila melanogaster Dmel_CG2139   CG2139 gene product from transcript CG2139-RC
Homo sapiens ENSG00000004864   solute carrier family 25 (aspartate/glutamate carrier), member 13
Homo sapiens ENSG00000115840   solute carrier family 25 (aspartate/glutamate carrier), member 12
Mus musculus ENSMUSG00000015112   solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
Mus musculus 78830   solute carrier family 25 (mitochondrial carrier, Aralar), member 12
Saccharomyces cerevisiae YPR021C   Agc1p
Schistosoma japonicum Sjp_0009610   Probable calcium-binding mitochondrial carrier K02F3.2, putative
Schistosoma japonicum Sjp_0114610   Calcium-binding mitochondrial carrier protein Aralar1, putative
Schistosoma japonicum Sjp_0316410   Calcium-binding mitochondrial carrier protein Aralar1, putative
Schistosoma mansoni Smp_137160   mitochondrial solute carrier
Schmidtea mediterranea mk4.000141.08   Probable calcium-binding mitochondrial carrier

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_137160 (Schistosoma mansoni), mitochondrial solute carrier
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