Detailed view for Smp_001430

Basic information

TDR Targets ID: 288100
Schistosoma mansoni, ubiquinone biosynthesis protein
Source Database / ID:  GeneDB

pI: 6.4864 | Length (AA): 176 | MW (Da): 20464 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05019   Coenzyme Q (ubiquinone) biosynthesis protein Coq4

Gene Ontology

Mouse over links to read term descriptions.
GO:0005743   mitochondrial inner membrane  
GO:0006744   ubiquinone biosynthetic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 168 3msq (A) 55 221 23.00 0 0.98 1.26125 -0.72
1 167 6e12 (A) 51 215 26.00 0 0.99 1.25856 -0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128661)

Species Accession Gene Product
Arabidopsis thaliana AT2G03690   ubiquinone biosynthesis protein COQ4-like protein
Brugia malayi Bm1_53390   Ubiquinone biosynthesis protein COQ4 homolog
Candida albicans CaO19.10526   Protein involved in biosynthesis of coenzyme Q
Candida albicans CaO19.3008   Protein involved in biosynthesis of coenzyme Q
Caenorhabditis elegans CELE_T03F1.2   Protein COQ-4
Cryptosporidium hominis Chro.10049   ubiquinone biosynthesis protein COQ4 (Coenzyme Q biosynthesis protein 4 ) (CGI-92)
Cryptosporidium parvum cgd1_380   conserved hypothetical protein
Dictyostelium discoideum DDB_G0292620   coenzyme Q biosynthesis protein
Drosophila melanogaster Dmel_CG32174   CG32174 gene product from transcript CG32174-RD
Homo sapiens ENSG00000167113   coenzyme Q4
Leishmania braziliensis LbrM.09.1490   ubiquinone biosynthesis protein-like protein, putative
Leishmania donovani LdBPK_091500.1   ubiquinone biosynthesis protein-like protein, putative
Leishmania infantum LinJ.09.1500   ubiquinone biosynthesis protein-like protein, putative
Leishmania major LmjF.09.1430   ubiquinone biosynthesis protein-like protein, putative
Leishmania mexicana LmxM.09.1430   ubiquinone biosynthesis protein-like protein, putative
Loa Loa (eye worm) LOAG_00995   hypothetical protein
Mus musculus ENSMUSG00000026798   coenzyme Q4 homolog (yeast)
Neospora caninum NCLIV_007060   ubiquinone biosynthesis protein COQ4, putative
Oryza sativa 4338019   Os05g0188800
Oryza sativa 4337378   Os04g0674200
Plasmodium berghei PBANKA_0935400   ubiquinone biosynthesis protein COQ4, putative
Plasmodium falciparum PF3D7_1112200   ubiquinone biosynthesis protein COQ4, putative
Plasmodium knowlesi PKNH_0909900   ubiquinone biosynthesis protein COQ4, putative
Plasmodium vivax PVX_091260   ubiquinone biosynthesis protein COQ4, putative
Plasmodium yoelii PY05764   putative ubiquinone biosynthesis protein
Saccharomyces cerevisiae YDR204W   Coq4p
Schistosoma japonicum Sjp_0114790   Ubiquinone biosynthesis protein COQ4 homolog, putative
Schistosoma mansoni Smp_001430   ubiquinone biosynthesis protein
Schmidtea mediterranea mk4.000567.03   Ubiquinone biosynthesis protein coq-4, mitochondrial
Trypanosoma brucei gambiense Tbg972.11.15160   ubiquinone biosynthesis protein-like protein, putative
Trypanosoma brucei Tb927.11.13580   ubiquinone biosynthesis protein-like protein
Trypanosoma congolense TcIL3000.11.13910   ubiquinone biosynthesis protein-like protein
Trypanosoma cruzi TcCLB.506753.170   ubiquinone biosynthesis protein-like protein, putative
Trypanosoma cruzi TcCLB.510357.70   ubiquinone biosynthesis protein-like protein, putative
Toxoplasma gondii TGME49_275980   coenzyme q (ubiquinone) biosynthesis protein coq4 protein

Essentiality

Smp_001430 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.5180 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.5180 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.5180 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.01.5180 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0935400 Plasmodium berghei Essential plasmo
TGME49_275980 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Smp_001430 (Schistosoma mansoni), ubiquinone biosynthesis protein
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