Detailed view for Smp_086900

Basic information

TDR Targets ID: 290321
Schistosoma mansoni, ADP-ribosylation factor arf
Source Database / ID:  GeneDB

pI: 7.7047 | Length (AA): 180 | MW (Da): 20165 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00025   ADP-ribosylation factor family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005525   GTP binding  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 180 1moz (A) 2 182 59.00 0 1 1.77524 -1.41
6 176 4y0v (A) 3 173 58.00 0 1 1.7379 -1.49
14 180 1upt (A) 15 181 75.00 0 1 1.92858 -1.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128805)

Species Accession Gene Product
Brugia malayi Bm1_38140   GTP-binding ADP-ribosylation factor homolog 1 protein, putative
Candida albicans CaO19.12073   potential ARF-like GTPase similar to S. cerevisiae ARL1 (YBR164C) which interacts with Golgi vesicle tethering factors
Candida albicans CaO19.4603   potential ARF-like GTPase similar to S. cerevisiae ARL1 (YBR164C) which interacts with Golgi vesicle tethering factors
Caenorhabditis elegans CELE_F54C9.10   Protein ARL-1
Dictyostelium discoideum DDB_G0288163   ADP-ribosylation factor-like protein
Drosophila melanogaster Dmel_CG6025   ADP ribosylation factor-like 1
Echinococcus granulosus EgrG_000394000   ADP ribosylation factor protein 1
Entamoeba histolytica EHI_092730   ADP-ribosylation factor 1, putative
Echinococcus multilocularis EmuJ_000394000   ADP ribosylation factor protein 1
Homo sapiens ENSG00000120805   ADP-ribosylation factor-like 1
Leishmania braziliensis LbrM.17.0080   ADP-ribosylation factor-like protein 1, putative;with=GeneDB:LmjF17.0070
Leishmania donovani LdBPK_170080.1   ADP-ribosylation factor, putative
Leishmania infantum LinJ.17.0080   ADP-ribosylation factor-like protein 1
Leishmania major LmjF.17.0070   ADP-ribosylation factor-like protein 1
Leishmania mexicana LmxM.17.0070   ADP-ribosylation factor, putative
Loa Loa (eye worm) LOAG_03618   adp-ribosylation factor
Mus musculus ENSMUSG00000060904   ADP-ribosylation factor-like 1
Neospora caninum NCLIV_025040   ADP-ribosylation factor domain-containing protein, putative
Oryza sativa 4345072   Os08g0248900
Plasmodium berghei PBANKA_0518500   ADP-ribosylation factor, putative
Plasmodium falciparum PF3D7_1034700   ADP-ribosylation factor, putative
Plasmodium knowlesi PKNH_0619900   ADP-ribosylation factor, putative
Plasmodium vivax PVX_110990   ADP-ribosylation factor-like protein, putative
Plasmodium yoelii PY05471   ADP-ribosylation factor-like protein
Saccharomyces cerevisiae YBR164C   Arf family GTPase ARL1
Schistosoma japonicum Sjp_0213630   ko:K07942 ADP-ribosylation factor-like 1, putative
Schistosoma mansoni Smp_086900   ADP-ribosylation factor arf
Schmidtea mediterranea mk4.050813.00   ADP-ribosylation factor-like protein 1
Schmidtea mediterranea mk4.007468.02   ADP-ribosylation factor-like protein 1
Schmidtea mediterranea mk4.000354.00   ADP-ribosylation factor-like protein 1
Trypanosoma brucei gambiense Tbg972.7.7200   ADP-ribosylation factor, putative,ARF3
Trypanosoma brucei Tb927.7.6230   ADP-ribosylation factor, putative
Trypanosoma congolense TcIL3000_7_5080   ADP-ribosylation factor, putative
Trypanosoma cruzi TcCLB.506513.60   ADP-ribosylation factor, putative
Trypanosoma cruzi TcCLB.508919.60   ADP-ribosylation factor, putative
Toxoplasma gondii TGME49_262860   ADP-ribosylation factor family protein 1, putative
Trichomonas vaginalis TVAG_353380   ADP-ribosylation factor, arf, putative

Essentiality

Smp_086900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.6230 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.6230 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.6230 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.7.6230 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F54C9.10 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_0518500 Plasmodium berghei Dispensable plasmo
TGME49_262860 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_086900 (Schistosoma mansoni), ADP-ribosylation factor arf
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