Detailed view for Smp_151050

Basic information

TDR Targets ID: 291878
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.4954 | Length (AA): 395 | MW (Da): 44651 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00651   BTB/POZ domain
PF00917   MATH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
46 350 3hqi (A) 28 329 64.00 0 1 1.46505 -0.01
230 309 3fkc (A) 41 116 30.00 0 0.96 0.583132 -0.77

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128326)

Species Accession Gene Product
Arabidopsis thaliana AT2G39760   BTB/POZ and MATH domain-containing protein
Arabidopsis thaliana AT5G19000   BTB-POZ and math domain-containing protein
Arabidopsis thaliana AT3G06190   BTB/POZ and M2 domain-containing protein
Brugia malayi Bm1_45730   Speckle-type POZ protein
Caenorhabditis elegans CELE_T16H12.5   Protein BATH-43, isoform B
Dictyostelium discoideum DDB_G0292428   hypothetical protein
Drosophila melanogaster Dmel_CG12537   roadkill
Echinococcus granulosus EgrG_001167200   speckle type POZ protein
Echinococcus multilocularis EmuJ_001167200   speckle type POZ protein
Homo sapiens ENSG00000144228   speckle-type POZ protein-like
Homo sapiens ENSG00000121067   speckle-type POZ protein
Loa Loa (eye worm) LOAG_12967   speckle-type POZ protein
Loa Loa (eye worm) LOAG_13045   speckle-type POZ protein
Mus musculus ENSMUSG00000026771   speckle-type POZ protein-like
Mus musculus ENSMUSG00000057522   speckle-type POZ protein
Oryza sativa 4348684   Os10g0428500
Oryza sativa 4348704   Os10g0435400
Oryza sativa 4344979   Os08g0226800
Oryza sativa 4344982   Os08g0227400
Oryza sativa 9266845   Os11g0622150
Oryza sativa 9271904   Os11g0616500
Oryza sativa 9270206   Os11g0433300
Oryza sativa 4348671   Os10g0425900
Oryza sativa 4348663   Os10g0423300
Oryza sativa 9270861   Os10g0427400
Oryza sativa 4348665   Os10g0423800
Oryza sativa 4348676   Os10g0426800
Oryza sativa 9271544   Os10g0425500
Oryza sativa 4348679   Os10g0427600
Oryza sativa 4344981   Os08g0227200
Oryza sativa 4348670   Os10g0425700
Oryza sativa 4348681   Os10g0427800
Oryza sativa 4344139   Os07g0655300
Oryza sativa 4344686   Os08g0154700
Oryza sativa 9271344   Os11g0630900
Oryza sativa 4348669   Os10g0425400
Oryza sativa 4348666   Os10g0423900
Oryza sativa 4350951   Os11g0622600
Oryza sativa 9271421   Os10g0429500
Oryza sativa 4348673   Os10g0426500
Oryza sativa 4348664   Os10g0423600
Oryza sativa 4344984   Os08g0228200
Oryza sativa 4348674   Os10g0426600
Oryza sativa 9268933   Os10g0434200
Oryza sativa 9268219   Os04g0433000
Oryza sativa 9267736   Os10g0427000
Oryza sativa 4348685   Os10g0428900
Oryza sativa 4342170   Os07g0101400
Oryza sativa 4348686   Os10g0429300
Oryza sativa 9266424   Os11g0630600
Oryza sativa 9266852   Os10g0424500
Schistosoma mansoni Smp_151050   hypothetical protein
Schistosoma mansoni Smp_117940   speckle-type poz protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_151050 (Schistosoma mansoni), hypothetical protein
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