Detailed view for Smp_194920

Basic information

TDR Targets ID: 292030
Schistosoma mansoni, T-cell immunomodulatory protein
Source Database / ID:  GeneDB

pI: 4.6457 | Length (AA): 657 | MW (Da): 72107 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13517   Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
185 408 3vi3 (A) 189 389 28.00 0.37 0.31 0.362444 0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129241)

Species Accession Gene Product
Babesia bovis BBOV_II004990   T-cell immunomodulatory protein-like protein precursor, putative
Brugia malayi Bm1_13530   FG-GAP repeat family protein
Caenorhabditis elegans CELE_ZK637.3   Protein TAG-256
Cryptosporidium hominis Chro.50304   hypothetical protein
Cryptosporidium parvum cgd5_830   membrane associated protein with a transmembrane domain near C-terminus
Dictyostelium discoideum DDB_G0292418   hypothetical protein
Drosophila melanogaster Dmel_CG7739   CG7739 gene product from transcript CG7739-RA
Entamoeba histolytica EHI_009410   hypothetical protein, conserved
Giardia lamblia GL50803_36426   Hypothetical protein
Homo sapiens 81533   integrin alpha FG-GAP repeat containing 1
Leishmania donovani LdBPK_282640.1   hypothetical protein, conserved
Leishmania infantum LinJ.28.2640   hypothetical protein, conserved
Leishmania major LmjF.28.2450   hypothetical protein, conserved
Leishmania mexicana LmxM.28.2450   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_07214   FG-GAP repeat family protein
Mus musculus ENSMUSG00000031703   integrin alpha FG-GAP repeat containing 1
Neospora caninum NCLIV_011990   T-cell immunomodulatory protein, putative
Plasmodium berghei PBANKA_1243600   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0529000   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1003700   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_079800   T-cell immunomodulatory protein homolog precursor, putative
Plasmodium yoelii PY00695   Homo sapiens CDA08-related
Schistosoma japonicum Sjp_0045550   IPR008162,Inorganic pyrophosphatase,domain-containing
Schistosoma mansoni Smp_194920   T-cell immunomodulatory protein
Schmidtea mediterranea mk4.000813.07  
Trypanosoma brucei gambiense Tbg972.11.13150   FG-GAP repeat protein, putative,intergrin alpha chain protein, putative
Trypanosoma brucei Tb927.11.11720   FG-GAP repeat protein, putative
Trypanosoma congolense TcIL3000.11.12350   FG-GAP repeat protein, putative
Trypanosoma cruzi TcCLB.511209.50   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506025.20   hypothetical protein, conserved
Toxoplasma gondii TGME49_301450   FG-GAP repeat-containing protein
Theileria parva TP04_0039   hypothetical protein, conserved
Trichomonas vaginalis TVAG_110440   hypothetical protein

Essentiality

Smp_194920 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.3590 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.3590 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.3590 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.3590 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_ZK637.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK637.3 Caenorhabditis elegans larval arrest wormbase
CELE_ZK637.3 Caenorhabditis elegans sterile wormbase
PBANKA_1243600 Plasmodium berghei Essential plasmo
TGME49_301450 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_194920 (Schistosoma mansoni), T-cell immunomodulatory protein
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