Detailed view for Smp_062300.1

Basic information

TDR Targets ID: 292125
Schistosoma mansoni, rac gtpase
Source Database / ID:  GeneDB

pI: 7.9299 | Length (AA): 188 | MW (Da): 20968 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0003924   GTPase activity  
GO:0005525   GTP binding  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  

Metabolic Pathways

Phagosome (KEGG)
Wnt signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 177 1ryf (A) 1 200 77.00 0 1 1.84499 -1.57
1 188 2ngr (A) 1 191 66.00 0 1 1.8739 -1.43
3 172 3bji (D) 3 176 79.00 0 1 1.85166 -1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126995)

Species Accession Gene Product
Arabidopsis thaliana AT5G62880   Rac-like GTP-binding protein ARAC10
Arabidopsis thaliana AT2G17800   Rac-like GTP-binding protein ARAC1
Arabidopsis thaliana AT1G20090   Rac-like GTP-binding protein ARAC4
Arabidopsis thaliana AT4G35950   Rac-like GTP-binding protein ARAC6
Arabidopsis thaliana AT4G35020   Rac-like GTP-binding protein ARAC3
Arabidopsis thaliana AT5G45970   Rac-like GTP-binding protein ARAC2
Arabidopsis thaliana AT3G51300   Rac-like GTP-binding protein ARAC11
Arabidopsis thaliana AT2G44690   Rac-like GTP-binding protein ARAC9
Arabidopsis thaliana AT1G75840   Rac-like GTP-binding protein ARAC5
Arabidopsis thaliana AT3G48040   Rac-like GTP-binding protein ARAC8
Brugia malayi Bm1_34040   small GTPase
Brugia malayi Bm1_00680   Ras-related protein Rac1
Candida albicans CaO19.6237   one of two genes similar to S. cerevisiae CDC42 (YLR229C) rho family small monomeric GTPase
Candida albicans CaO19.13617   one of two genes similar to S. cerevisiae CDC42 (YLR229C) rho family small monomeric GTPase
Caenorhabditis elegans CELE_K03D3.10   Protein RAC-2
Caenorhabditis elegans CELE_C35C5.4   Protein MIG-2
Dictyostelium discoideum DDB_G0268622   Rho GTPase
Dictyostelium discoideum DDB_G0282365   Rho GTPase
Dictyostelium discoideum DDB_G0279605   Rho GTPase
Dictyostelium discoideum DDB_G0277869   Rho GTPase
Drosophila melanogaster Dmel_CG2248   CG2248 gene product from transcript CG2248-RB
Drosophila melanogaster Dmel_CG8556   CG8556 gene product from transcript CG8556-RB
Drosophila melanogaster Dmel_CG5588   Mig-2-like
Echinococcus granulosus EgrG_000261400   ras C3 botulinum toxin substrate 2
Entamoeba histolytica EHI_197840   Rho family GTPase
Entamoeba histolytica EHI_129750   Rho family GTPase
Entamoeba histolytica EHI_067220   Rho family GTPase
Entamoeba histolytica EHI_181250   Rho family GTPase
Entamoeba histolytica EHI_140190   Rho family GTPase
Entamoeba histolytica EHI_012240   Rho family GTPase
Echinococcus multilocularis EmuJ_000261400   ras C3 botulinum toxin substrate 2
Echinococcus multilocularis EmuJ_000522200   Ras C3 botulinum toxin substrate 1
Giardia lamblia GL50803_8496   Rac/Rho-like protein
Homo sapiens ENSG00000169750   ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
Homo sapiens ENSG00000136238   ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Homo sapiens ENSG00000128340   ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Loa Loa (eye worm) LOAG_06394   rac GTPase
Loa Loa (eye worm) LOAG_03639   small GTPase
Mus musculus ENSMUSG00000001847   RAS-related C3 botulinum substrate 1
Mus musculus ensembl-mmu:ENSMUSG00000018012   RAS-related C3 botulinum substrate 3
Mus musculus ENSMUSG00000033220   RAS-related C3 botulinum substrate 2
Oryza sativa 4325879   Os01g0229400
Oryza sativa 4340590   Os06g0234200
Oryza sativa 4331272   Os02g0834000
Oryza sativa 4328116   Os02g0120800
Oryza sativa 4329132   Os02g0312600
Oryza sativa 4330693   Os02g0742200
Onchocerca volvulus OVOC5588  
Schistosoma japonicum Sjp_0207180   Transforming protein RhoA precursor, putative
Schistosoma japonicum Sjp_0209090   ko:K04392 Ras-related C3 botulinum toxin substrate 1, putative
Schistosoma mansoni Smp_062300.1   rac gtpase
Schistosoma mansoni Smp_104110   gtpase_rho
Schmidtea mediterranea mk4.012448.00   Rho-related GTP-binding protein RhoH
Schmidtea mediterranea mk4.002609.02  
Schmidtea mediterranea mk4.001607.06   Rho-related GTP-binding protein RhoG
Schmidtea mediterranea mk4.001607.03   Rho-related GTP-binding protein RhoG
Schmidtea mediterranea mk4.024013.00   Rho-related GTP-binding protein RhoG
Schmidtea mediterranea mk4.013926.00   Rho-related GTP-binding protein RhoG
Schmidtea mediterranea mk4.007124.00   Rho-related GTP-binding protein RhoH
Schmidtea mediterranea mk4.004839.01   Ras-like GTP-binding protein rhoA
Schmidtea mediterranea mk4.002609.01  
Schmidtea mediterranea mk4.001607.04   Rho-related GTP-binding protein RhoG
Schmidtea mediterranea mk4.019483.00   Ras-like GTP-binding protein rhoA
Trypanosoma cruzi TcCLB.508351.50   rho-like GTP binding protein, putative
Trypanosoma cruzi TcCLB.506649.40   rho-like GTP binding protein, putative
Trichomonas vaginalis TVAG_572140   rho5 protein, putative
Trichomonas vaginalis TVAG_462480   rho4, putative
Trichomonas vaginalis TVAG_169060   GTPase_rho, putative
Trichomonas vaginalis TVAG_272360   rho4, putative

Essentiality

Smp_062300.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K03D3.10 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_062300.1 (Schistosoma mansoni), rac gtpase
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