Detailed view for Smp_000310.1

Basic information

TDR Targets ID: 294742
Schistosoma mansoni, D2013.10
Source Database / ID:  GeneDB

pI: 8.2953 | Length (AA): 248 | MW (Da): 27946 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09335   SNARE associated Golgi protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
68 138 4ky0 (A) 15 93 28.00 0 0.01 0.0247903 4.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128091)

Species Accession Gene Product
Arabidopsis thaliana AT1G71940   SNARE associated Golgi protein family
Arabidopsis thaliana AT4G09580   SNARE associated Golgi protein family
Arabidopsis thaliana AT4G17790   SNARE associated Golgi protein
Brugia malayi Bm1_06500   KIAA0033
Caenorhabditis elegans CELE_T07F10.4   Protein BUS-19, isoform A
Caenorhabditis elegans CELE_D2013.10   Protein TAG-175
Caenorhabditis elegans CELE_Y71A12C.2   Protein Y71A12C.2
Dictyostelium discoideum DDB_G0275543   hypothetical protein
Drosophila melanogaster Dmel_CG8408   Stasimon
Echinococcus granulosus EgrG_001015200   transmembrane protein 41B
Echinococcus multilocularis EmuJ_001015200   transmembrane protein 41B
Homo sapiens ENSG00000166471   transmembrane protein 41B
Homo sapiens ENSG00000163900   transmembrane protein 41A
Leishmania braziliensis LbrM.12.0910   hypothetical protein, conserved
Leishmania donovani LdBPK_120810.1   SNARE associated Golgi protein, putative
Leishmania infantum LinJ.12.0810   hypothetical protein, conserved
Leishmania major LmjF.12.1230   hypothetical protein, conserved
Leishmania mexicana LmxM.12.1230   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_09667   hypothetical protein
Loa Loa (eye worm) LOAG_16181   hypothetical protein
Loa Loa (eye worm) LOAG_10196   hypothetical protein
Mus musculus ENSMUSG00000047554   transmembrane protein 41B
Mus musculus ENSMUSG00000022856   transmembrane protein 41a
Neospora caninum NCLIV_038420   hypothetical protein
Oryza sativa 4336832   Os04g0592600
Oryza sativa 4330389   Os02g0693500
Oryza sativa 4333847   Os03g0703900
Onchocerca volvulus OVOC1000   Transmembrane protein 41A homolog
Plasmodium berghei PBANKA_0109300   SNARE associated Golgi protein, putative
Plasmodium falciparum PF3D7_0611000   SNARE associated Golgi protein, putative
Plasmodium knowlesi PKNH_1139400   SNARE associated Golgi protein, putative
Plasmodium vivax PVX_113685   SNARE associated Golgi protein, putative
Plasmodium yoelii PY03114   Mus musculus RIKEN cDNA 5730578N08 gene
Schistosoma japonicum Sjp_0024840   Transmembrane protein 41B, putative
Schistosoma mansoni Smp_000310.1   D2013.10
Schistosoma mansoni Smp_000310.2   D2013.10
Schmidtea mediterranea mk4.003386.03   Transmembrane protein 41 homolog
Schmidtea mediterranea mk4.004190.03   Transmembrane protein 41 homolog
Schmidtea mediterranea mk4.001266.03  
Trypanosoma brucei gambiense Tbg972.1.3030   SNARE-associated golgi protein, putative
Trypanosoma brucei Tb927.1.4500   SNARE associated Golgi protein, putative
Trypanosoma congolense TcIL3000_1_1840   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510885.20   SNARE associated Golgi protein, putative
Trypanosoma cruzi TcCLB.506529.110   SNARE associated Golgi protein, putative
Toxoplasma gondii TGME49_279370   SNARE associated Golgi protein

Essentiality

Smp_000310.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.4500 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.4500 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.4500 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.4500 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_279370 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_000310.1 (Schistosoma mansoni), D2013.10
Title for this comment
Comment