pI: 8.1205 |
Length (AA): 1035 |
MW (Da): 115329 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
56 | 1026 | 4lhd (A) | 24 | 977 | 49.00 | 0 | 1 | 1.55446 | -0.96 |
68 | 499 | 1wyu (A) | 2 | 430 | 30.00 | 0 | 1 | 0.764591 | 0.05 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127334)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G26080 | glycine decarboxylase P-protein 2 |
Arabidopsis thaliana | AT4G33010 | glycine dehydrogenase [decarboxylating] 2 |
Candida albicans | CaO19.385 | P-subunit of glycine cleavage system |
Candida albicans | CaO19.8015 | P-subunit of glycine cleavage system |
Caenorhabditis elegans | CELE_R12C12.1 | Protein R12C12.1, isoform B |
Dictyostelium discoideum | DDB_G0287255 | glycine cleavage system P-protein |
Drosophila melanogaster | Dmel_CG3999 | CG3999 gene product from transcript CG3999-RA |
Escherichia coli | b2903 | glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex |
Homo sapiens | ENSG00000178445 | glycine dehydrogenase (decarboxylating) |
Leishmania braziliensis | LbrM.26.0050 | glycine dehydrogenase, putative |
Leishmania donovani | LdBPK_260040.1 | glycine dehydrogenase, putative |
Leishmania infantum | LinJ.26.0040 | pyridoxal phosphate containing glycine decarboxylase, putative |
Leishmania major | LmjF.26.0030 | pyridoxal phosphate containing glycine decarboxylase, putative;with=GeneDB:LinJ26_V3.0040 |
Leishmania mexicana | LmxM.26.0030 | glycine dehydrogenase, putative |
Mycobacterium leprae | ML2072c | Probable glycine dehydrogenase GcvB (Glycine decarboxylase) (Glycine cleavage system P-protein) |
Mus musculus | ENSMUSG00000024827 | glycine decarboxylase |
Mycobacterium tuberculosis | Rv1832 | Probable glycine dehydrogenase GcvB (glycine decarboxylase) (glycine cleavage system P-protein) |
Mycobacterium ulcerans | MUL_3050 | glycine dehydrogenase |
Oryza sativa | 4341516 | Os06g0611900 |
Oryza sativa | 4325932 | Os01g0711400 |
Saccharomyces cerevisiae | YMR189W | glycine decarboxylase subunit P |
Schistosoma japonicum | Sjp_0088350 | ko:K00282 glycine dehydrogenase subunit 1 [EC1.4.4.2A], putative |
Schistosoma japonicum | Sjp_0067640 | ko:K00282 glycine dehydrogenase subunit 1 [EC1.4.4.2A], putative |
Schistosoma mansoni | Smp_128690 | glycine dehydrogenase (decarboxylating) |
Schmidtea mediterranea | mk4.003329.04 | |
Schmidtea mediterranea | mk4.003329.02 | Glycine dehydrogenase |
Schmidtea mediterranea | mk4.012677.02 | Glycine dehydrogenase |
Schmidtea mediterranea | mk4.002654.00 | Glycine dehydrogenase |
Schmidtea mediterranea | mk4.002654.01 | |
Schmidtea mediterranea | mk4.009693.02 | |
Trypanosoma brucei gambiense | Tbg972.7.1900 | glycine dehydrogenase, putative |
Trypanosoma brucei | Tb927.7.1910 | pyridoxal phosphate containing glycine decarboxylase, putative |
Trypanosoma congolense | TcIL3000_7_1350 | pyridoxal phosphate containing glycine decarboxylase, putative |
Trypanosoma cruzi | TcCLB.510911.50 | glycine dehydrogenase [decarboxylating], putative |
Trypanosoma cruzi | TcCLB.509163.80 | glycine dehydrogenase [decarboxylating], putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.1910 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.1910 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.1910 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.1910 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2903 | Escherichia coli | non-essential | goodall |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.