pI: 7.738 |
Length (AA): 314 |
MW (Da): 36344 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 147 | 4v3d (A) | 528 | 670 | 11.00 | 0.42 | 0 | 0.542714 | -0.09 |
30 | 156 | 3ffz (A) | 854 | 970 | 30.00 | 0.52 | 0.05 | 0.389559 | 1.17 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Oocyst, Male Gametocyte. | Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Female Gametocyte. | Lasonder E |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_127686)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G52760 | Integral membrane Yip1 family protein |
Arabidopsis thaliana | AT2G36300 | Integral membrane Yip1-like protein |
Babesia bovis | BBOV_IV009820 | hypothetical protein |
Brugia malayi | Bm1_34720 | Yip1 domain containing protein |
Candida albicans | CaO19.3951 | vesicular transport |
Candida albicans | CaO19.11433 | vesicular transport |
Caenorhabditis elegans | CELE_F32D8.14 | Protein F32D8.14, isoform B |
Cryptosporidium hominis | Chro.40099 | CG12404-PA |
Cryptosporidium parvum | cgd4_800 | Yip1p like integral membrane protein |
Dictyostelium discoideum | DDB_G0283541 | Yip1 domain-containing protein |
Drosophila melanogaster | Dmel_CG12404 | CG12404 gene product from transcript CG12404-RA |
Echinococcus granulosus | EgrG_001082100 | protein YIPF5 YIP1 family |
Entamoeba histolytica | EHI_118460 | Golgi membrane protein, putative |
Echinococcus multilocularis | EmuJ_001082100 | protein YIPF5 (YIP1 family) |
Giardia lamblia | GL50803_8565 | Yip |
Homo sapiens | ENSG00000145817 | Yip1 domain family, member 5 |
Homo sapiens | ENSG00000177752 | Yip1 domain family, member 7 |
Leishmania braziliensis | LbrM.26.2120 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_262210.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.26.2210 | hypothetical protein, conserved |
Leishmania major | LmjF.26.2200 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.26.2200 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_02948 | Yip1 domain-containing protein |
Mus musculus | ENSMUSG00000024487 | Yip1 domain family, member 5 |
Mus musculus | ENSMUSG00000029158 | Yip1 domain family, member 7 |
Neospora caninum | NCLIV_051360 | Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YIPA_yeast, related |
Oryza sativa | 4332496 | Os03g0289200 |
Onchocerca volvulus | OVOC7351 |
|
Plasmodium berghei | PBANKA_1335300 | protein transport protein YIP1, putative |
Plasmodium falciparum | PF3D7_1472100 | protein transport protein YIP1, putative |
Plasmodium knowlesi | PKNH_1208900 | protein transport protein YIP1, putative |
Plasmodium vivax | PVX_116875 | hypothetical protein, conserved |
Plasmodium yoelii | PY05360 | hypothetical protein |
Saccharomyces cerevisiae | YGR172C | Yip1p |
Schistosoma japonicum | Sjp_0049330 | Protein YIPF5, putative |
Schistosoma mansoni | Smp_027080 | golgi membrane protein sb140 (yip1b) |
Schmidtea mediterranea | mk4.001845.00 | Golgi membrane protein sb140 |
Trypanosoma brucei gambiense | Tbg972.9.750 | membrane protein YIP1, putative |
Trypanosoma brucei | Tb927.9.2050 | membrane protein YIP1, putative |
Trypanosoma congolense | TcIL3000_9_530 | membrane protein YIP1, putative |
Trypanosoma cruzi | TcCLB.508119.160 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.507939.30 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_214110 | protein yipf5, putative |
Theileria parva | TP01_0786 | hypothetical protein |
Trichomonas vaginalis | TVAG_117010 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_403300 | golgi membrane protein sb140, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.0840 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.0840 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.0840 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.160.0840 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
YGR172C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1335300 | Plasmodium berghei | Essential | plasmo |
TGME49_214110 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.