Detailed view for PF3D7_1472100

Basic information

TDR Targets ID: 3019
Plasmodium falciparum, protein transport protein YIP1, putative

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.738 | Length (AA): 314 | MW (Da): 36344 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04893   Yip1 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0003674   molecular_function  
GO:0016020   membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 147 4v3d (A) 528 670 11.00 0.42 0 0.542714 -0.09
30 156 3ffz (A) 854 970 30.00 0.52 0.05 0.389559 1.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, gametocyte, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Oocyst, Male Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte. Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127686)

Species Accession Gene Product
Arabidopsis thaliana AT3G52760   Integral membrane Yip1 family protein
Arabidopsis thaliana AT2G36300   Integral membrane Yip1-like protein
Babesia bovis BBOV_IV009820   hypothetical protein
Brugia malayi Bm1_34720   Yip1 domain containing protein
Candida albicans CaO19.3951   vesicular transport
Candida albicans CaO19.11433   vesicular transport
Caenorhabditis elegans CELE_F32D8.14   Protein F32D8.14, isoform B
Cryptosporidium hominis Chro.40099   CG12404-PA
Cryptosporidium parvum cgd4_800   Yip1p like integral membrane protein
Dictyostelium discoideum DDB_G0283541   Yip1 domain-containing protein
Drosophila melanogaster Dmel_CG12404   CG12404 gene product from transcript CG12404-RA
Echinococcus granulosus EgrG_001082100   protein YIPF5 YIP1 family
Entamoeba histolytica EHI_118460   Golgi membrane protein, putative
Echinococcus multilocularis EmuJ_001082100   protein YIPF5 (YIP1 family)
Giardia lamblia GL50803_8565   Yip
Homo sapiens ENSG00000145817   Yip1 domain family, member 5
Homo sapiens ENSG00000177752   Yip1 domain family, member 7
Leishmania braziliensis LbrM.26.2120   hypothetical protein, conserved
Leishmania donovani LdBPK_262210.1   hypothetical protein, conserved
Leishmania infantum LinJ.26.2210   hypothetical protein, conserved
Leishmania major LmjF.26.2200   hypothetical protein, conserved
Leishmania mexicana LmxM.26.2200   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02948   Yip1 domain-containing protein
Mus musculus ENSMUSG00000024487   Yip1 domain family, member 5
Mus musculus ENSMUSG00000029158   Yip1 domain family, member 7
Neospora caninum NCLIV_051360   Similarity to HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YIPA_yeast, related
Oryza sativa 4332496   Os03g0289200
Onchocerca volvulus OVOC7351  
Plasmodium berghei PBANKA_1335300   protein transport protein YIP1, putative
Plasmodium falciparum PF3D7_1472100   protein transport protein YIP1, putative
Plasmodium knowlesi PKNH_1208900   protein transport protein YIP1, putative
Plasmodium vivax PVX_116875   hypothetical protein, conserved
Plasmodium yoelii PY05360   hypothetical protein
Saccharomyces cerevisiae YGR172C   Yip1p
Schistosoma japonicum Sjp_0049330   Protein YIPF5, putative
Schistosoma mansoni Smp_027080   golgi membrane protein sb140 (yip1b)
Schmidtea mediterranea mk4.001845.00   Golgi membrane protein sb140
Trypanosoma brucei gambiense Tbg972.9.750   membrane protein YIP1, putative
Trypanosoma brucei Tb927.9.2050   membrane protein YIP1, putative
Trypanosoma congolense TcIL3000_9_530   membrane protein YIP1, putative
Trypanosoma cruzi TcCLB.508119.160   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507939.30   hypothetical protein, conserved
Toxoplasma gondii TGME49_214110   protein yipf5, putative
Theileria parva TP01_0786   hypothetical protein
Trichomonas vaginalis TVAG_117010   conserved hypothetical protein
Trichomonas vaginalis TVAG_403300   golgi membrane protein sb140, putative

Essentiality

PF3D7_1472100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.160.0840 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.160.0840 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.160.0840 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.160.0840 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YGR172C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1335300 Plasmodium berghei Essential plasmo
TGME49_214110 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1472100 (Plasmodium falciparum), protein transport protein YIP1, putative
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