pI: 8.1828 |
Length (AA): 543 |
MW (Da): 59158 |
Paralog Number:
23
Signal peptide: Y | GPI Anchor: Y | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
59 | 508 | 1lml () | 101 | 565 | 39.00 | 0 | 1 | 1.27 | -0.18 |
27 | 137 | 1lm5 (A) | 2680 | 2799 | 29.00 | 0.51 | 0.23 | 0.22782 | 1.3 |
59 | 509 | 1lml (A) | 101 | 566 | 39.00 | 0 | 1 | 1.27737 | -0.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126749)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G42620 | metalloendopeptidase / zinc ion binding protein |
Brugia malayi | Bm1_53560 | RH66426p |
Caenorhabditis elegans | CELE_Y43F4A.1 | Protein Y43F4A.1, isoform B |
Dictyostelium discoideum | DDB_G0286533 | hypothetical protein |
Dictyostelium discoideum | DDB_G0282305 | hypothetical protein |
Dictyostelium discoideum | DDB_G0268270 | hypothetical protein |
Dictyostelium discoideum | DDB_G0293364 | peptidase M8, leishmanolysin family protein |
Drosophila melanogaster | Dmel_CG3953 | CG3953 gene product from transcript CG3953-RA |
Echinococcus granulosus | EgrG_000839500 | invadolysin M08 family |
Entamoeba histolytica | EHI_042870 | cell surface protease gp63, putative |
Entamoeba histolytica | EHI_200230 | cell surface protease gp63, putative |
Echinococcus multilocularis | EmuJ_000839500 | invadolysin (M08 family) |
Homo sapiens | ENSG00000185621 | leishmanolysin-like (metallopeptidase M8 family) |
Leishmania braziliensis | LbrM.10.0550 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.1680 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.1630 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.0540 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.0500 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.0520 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.0610 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.0510 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.1590 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.0470 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.0560 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.1650 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.1660 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.0590 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.1550 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.1610 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.0580 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.1620 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.1640 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.0480 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.1570 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.1690 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.0570 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.0530 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania braziliensis | LbrM.10.1670 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.1560 | GP63, leishmanolysin |
Leishmania braziliensis | LbrM.10.0600 | GP63, leishmanolysin |
Leishmania donovani | LdBPK_280600.1 | major surface protease gp63, putative |
Leishmania donovani | LdBPK_100520.1 | GP63, leishmanolysin |
Leishmania infantum | LinJ.10.0500 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania infantum | LinJ.10.0530 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania infantum | LinJ.28.0600 | major surface protease gp63, putative,leishmanolysin, putative |
Leishmania infantum | LinJ.10.0490 | GP63, leishmanolysin |
Leishmania infantum | LinJ.10.0520 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania infantum | LinJ.28.0610 | major surface protease gp63, putative,leishmanolysin, putative |
Leishmania infantum | LinJ.10.0510 | GP63, leishmanolysin,metallo-peptidase, Clan MA(M), Family M8 |
Leishmania major | LmjF.10.0465 | GP63, leishmanolysin |
Leishmania major | LmjF.10.0460 | GP63, leishmanolysin |
Leishmania major | LmjF.10.0470 | GP63, leishmanolysin |
Leishmania major | LmjF.28.0570 | major surface protease gp63, putative,leishmanolysin, putative |
Leishmania major | LmjF.10.0480 | GP63, leishmanolysin |
Leishmania mexicana | LmxM.10.0465 | GP63, leishmanolysin |
Leishmania mexicana | LmxM.28.0570 | major surface protease gp63, putative,leishmanolysin, putative |
Leishmania mexicana | LmxM.10.0405 | GP63, leishmanolysin |
Leishmania mexicana | LmxM.10.0470 | GP63, leishmanolysin |
Leishmania mexicana | LmxM.10.0465a | |
Leishmania mexicana | LmxM.10.0460 | GP63, leishmanolysin |
Leishmania mexicana | LmxM.10.0390 | GP63, leishmanolysin |
Loa Loa (eye worm) | LOAG_08471 | hypothetical protein |
Mus musculus | 239833 | leishmanolysin-like (metallopeptidase M8 family) |
Oryza sativa | 4334001 | Os03g0731500 |
Schistosoma japonicum | Sjp_0108000 | ko:K01404 leishmanolysin [EC3.4.24.36], putative |
Schistosoma japonicum | Sjp_0067490 | Leishmanolysin-like peptidase, putative |
Schistosoma japonicum | Sjp_0048370 | Leishmanolysin-like peptidase, putative |
Schistosoma mansoni | Smp_127030 | invadolysin (M08 family) |
Schistosoma mansoni | Smp_090110 | invadolysin (M08 family) |
Schistosoma mansoni | Smp_153930 | invadolysin (M08 family) |
Schistosoma mansoni | Smp_090100 | invadolysin (M08 family) |
Schmidtea mediterranea | mk4.019252.00 | |
Schmidtea mediterranea | mk4.028879.00 | |
Schmidtea mediterranea | mk4.005302.00 | |
Schmidtea mediterranea | mk4.032713.00 | |
Schmidtea mediterranea | mk4.009763.00 | |
Schmidtea mediterranea | mk4.002584.02 | Leishmanolysin-like peptidase |
Schmidtea mediterranea | mk4.019481.00 | |
Schmidtea mediterranea | mk4.003972.02 | |
Trypanosoma brucei gambiense | Tbg972.11.8480 | major surface protease A, putative,Gp63 major surface glycoprotein-like protein,MSP-A, putative |
Trypanosoma brucei gambiense | Tbg972.11.8840 | Gp63-1 surface protease homolog, putative |
Trypanosoma brucei gambiense | Tbg972.8.1230 | major surface protease gp63, putative,GP63, putative,metallopeptidase, putative |
Trypanosoma brucei | Tb927.11.7720 | Gp63-1 surface protease homolog, putative |
Trypanosoma brucei | Tb11.v5.0710 | Gp63-1 surface protease homolog, putative |
Trypanosoma brucei | Tb927.11.7410 | MSP-A, putative |
Trypanosoma brucei | Tb927.11.7760 | MSP-A, putative |
Trypanosoma brucei | Tb927.8.1620 | MSP-B, putative |
Trypanosoma brucei | Tb927.11.7640 | Gp63-1 surface protease homolog, putative |
Trypanosoma brucei | Tb927.11.7630 | Gp63-1 surface protease homolog, putative |
Trypanosoma brucei | Tb927.11.7750 | MSP-A, putative |
Trypanosoma brucei | Tb927.8.1630 | MSP-B, putative |
Trypanosoma brucei | Tb11.v5.0601 | major surface protease gp63, putative |
Trypanosoma brucei | Tb927.8.1640 | MSP-B, putative |
Trypanosoma brucei | Tb11.v5.0511 | Gp63-3 surface protease homolog, putative |
Trypanosoma brucei | Tb11.0380 | chrXI additional, unordered contigs |
Trypanosoma brucei | Tb927.11.7620 | MSP-A, putative |
Trypanosoma brucei | Tb11.v5.0510 | Gp63-3 surface protease homolog, putative |
Trypanosoma congolense | TcIL3000_0_44090 | MSP-B, putative |
Trypanosoma congolense | TcIL3000.11.8250 | Major Surface Protease |
Trypanosoma congolense | TcIL3000_0_06370 | Major Surface Protease |
Trypanosoma congolense | TcIL3000_0_06380 | Major Surface Protease |
Trypanosoma congolense | TcIL3000.11.8010 | Major Surface Protease |
Trypanosoma cruzi | TcCLB.506401.380 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.507993.350 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.508999.170 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.410797.10 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.507917.10 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.511277.610 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.511151.54 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.508611.30 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.508609.10 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.511723.10 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.508693.100 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.511035.10 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.510761.80 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.508241.50 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.506321.240 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.510657.200 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.510263.30 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.508545.40 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.507919.10 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.505989.70 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.511281.50 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.511257.60 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.510747.40 | surface protease GP63, putative |
Trypanosoma cruzi | TcCLB.506435.370 | surface protease GP63, putative |
Trichomonas vaginalis | TVAG_295740 | Clan MA, family M8, leishmanolysin-like metallopeptidase |
Trichomonas vaginalis | TVAG_454520 | Clan MA, family M8, leishmanolysin-like metallopeptidase |
Trichomonas vaginalis | TVAG_000880 | Clan MA, family M8, leishmanolysin-like metallopeptidase |
Trichomonas vaginalis | TVAG_195440 | Clan MA, family M8, leishmanolysin-like metallopeptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.1610 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.1610 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.1610 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.1610 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.5610 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5610 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5610 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.5610 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.5310 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5310 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5310 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.5310 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.5640 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5640 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5640 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.02.5640 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.5630 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.5630 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.5630 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.5630 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Leishmania major | GP63, leishmanolysin | Compounds | References |