pI: 7.805 |
Length (AA): 383 |
MW (Da): 45260 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 364 | 1u7l (A) | 20 | 384 | 25.00 | 0 | 1 | 1.28 | -0.81 |
25 | 355 | 1u7l (A) | 32 | 351 | 26.00 | 0 | 1 | 1.28 | -1.16 |
9 | 383 | 1u7l (A) | 11 | 392 | 25.00 | 0 | 1 | 1.30361 | -0.6 |
143 | 268 | 4dl0 (I) | 153 | 265 | 35.00 | 0.00000027 | 1 | 0.699682 | -0.77 |
193 | 373 | 4uos (A) | 3 | 184 | 12.00 | 0.00091 | 0.13 | 0.657885 | -1.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, early trophozoite, late ring, late trophozoite. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | merozoite, sporozoite, early ring, late schizont, Oocyst, Ring, Sporozoite, Male Gametocyte. | PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | gametocyte. | PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Female Gametocyte. | Lasonder E |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_127946)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G12840 | V-type proton ATPase subunit C |
Babesia bovis | BBOV_III011050 | vacuolar ATPase subunit C family protein |
Brugia malayi | Bm1_39100 | V-ATPase subunit C family protein |
Candida albicans | CaO19.2166 | vacuolar ATPase (subunit C) |
Candida albicans | CaO19.9712 | vacuolar ATPase (subunit C) |
Caenorhabditis elegans | CELE_Y38F2AL.3 | Protein VHA-11, isoform A |
Cryptosporidium hominis | Chro.40070 | vacuolar ATP synthase |
Cryptosporidium parvum | cgd4_540 | putative vacuolar ATP synthase subunit C |
Dictyostelium discoideum | DDB_G0284473 | H(+)-transporting ATPase |
Drosophila melanogaster | Dmel_CG8048 | Vacuolar H[+] ATPase 44kD subunit |
Entamoeba histolytica | EHI_092600 | vacuolar ATP synthase subunit C, putative |
Giardia lamblia | GL50803_87058 | Vacuolar ATP synthase subunit C |
Homo sapiens | ENSG00000155097 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 |
Leishmania braziliensis | LbrM.18.0620 | vacuolar ATP synthase subunit c, putative |
Leishmania donovani | LdBPK_180560.1 | vacuolar ATP synthase subunit c, putative |
Leishmania infantum | LinJ.18.0560 | vacuolar ATP synthase subunit c, putative |
Leishmania major | LmjF.18.0560 | vacuolar ATP synthase subunit c, putative |
Leishmania mexicana | LmxM.18.0560 | vacuolar ATP synthase subunit c, putative |
Loa Loa (eye worm) | LOAG_03931 | V-ATPase subunit C family protein |
Mus musculus | ENSMUSG00000022295 | ATPase, H+ transporting, lysosomal V1 subunit C1 |
Neospora caninum | NCLIV_058310 | vacuolar ATP synthase subunit c, putative |
Oryza sativa | 4339800 | Os05g0593100 |
Plasmodium berghei | PBANKA_0207200 | V-type proton ATPase subunit C, putative |
Plasmodium falciparum | PF3D7_0106100 | V-type proton ATPase subunit C, putative |
Plasmodium knowlesi | PKNH_0207400 | V-type proton ATPase subunit C, putative |
Plasmodium vivax | PVX_081465 | vacuolar ATP synthase subunit c, putative |
Plasmodium yoelii | PY05774 | vacuolar ATP synthase subunit c |
Saccharomyces cerevisiae | YKL080W | H(+)-transporting V1 sector ATPase subunit C |
Schmidtea mediterranea | mk4.000790.02 | V-type proton ATPase subunit C |
Trypanosoma brucei gambiense | Tbg972.10.17240 | vacuolar ATP synthase subunit c, putative |
Trypanosoma brucei | Tb927.10.14040 | vacuolar ATP synthase subunit c, putative |
Trypanosoma congolense | TcIL3000_10_11650 | vacuolar ATP synthase subunit c, putative |
Trypanosoma cruzi | TcCLB.511277.240 | vacuolar ATP synthase subunit c, putative |
Toxoplasma gondii | TGME49_315620 | vacuolar ATP synthase subunit C, putative |
Theileria parva | TP02_0034 | vacuolar ATP synthase subunit C, putative |
Trichomonas vaginalis | TVAG_037610 | vacuolar ATP synthase subunit C, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14040 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14040 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14040 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.14040 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y38F2AL.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y38F2AL.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y38F2AL.3 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y38F2AL.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y38F2AL.3 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0207200 | Plasmodium berghei | Essential | plasmo |
TGME49_315620 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Manduca sexta | V-type proton ATPase subunit C | Compounds | References |