Detailed view for PF3D7_0110900

Basic information

TDR Targets ID: 3228
Plasmodium falciparum, adenylate kinase-like protein 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.7133 | Length (AA): 186 | MW (Da): 22173 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13238   AAA domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004017   adenylate kinase activity  
GO:0005524   ATP binding  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 186 2ak3 (A) 2 214 12.00 0 1 0.83 -0.34
4 183 1y63 (A) 9 176 25.00 0 1 1.29 -1.09
5 186 1rkb (A) 3 167 35.00 0 1 1.39 -0.85
2 185 1y63 (A) 7 178 26.00 0 1 1.22085 -0.39
4 37 1um8 (A) 141 174 24.00 0.27 0.04 0.326796 0.86
5 186 3iij (A) 3 167 37.00 0 1 1.40399 -0.61

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile early ring, early trophozoite, late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 24 hs, early schizont, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 32 hs, late schizont, Female Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 48 hs, Sporozoite, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 40 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127564)

Species Accession Gene Product
Arabidopsis thaliana AT5G60340   adenylate kinase isoenzyme 6
Arabidopsis thaliana AT5G60335   thioesterase-like protein
Babesia bovis BBOV_II007510   conserved hypothetical protein
Brugia malayi Bm1_24715   Hypothetical UPF0101 protein E02H1.6 in chromosome II, putative
Candida albicans CaO19.6074   oxidative stress
Candida albicans CaO19.13495   oxidative stress
Caenorhabditis elegans CELE_E02H1.6   Protein E02H1.6
Cryptosporidium hominis Chro.30373   protein ad-004
Cryptosporidium parvum cgd3_3270   possible nucleotide kinase related to CMP and AMP kinases
Dictyostelium discoideum DDB_G0278493   hypothetical protein
Drosophila melanogaster Dmel_CG8816   Adenylate kinase 6
Echinococcus granulosus EgrG_000855050   TAF9 RNA polymerase II TATA box binding protein
Entamoeba histolytica EHI_001120   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000855050   TAF9 RNA polymerase II, TATA box binding protein
Giardia lamblia GL50803_17258   Hemoglobin and proliferation regulated protein
Homo sapiens ENSG00000085231   adenylate kinase 6
Leishmania braziliensis LbrM.30.1840   hypothetical protein, conserved
Leishmania donovani LdBPK_301880.1   Adenylate kinase, nuclear
Leishmania infantum LinJ.30.1880   hypothetical protein, conserved
Leishmania major LmjF.30.1890   hypothetical protein, conserved
Leishmania mexicana LmxM.29.1890   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_09515   TATA box binding protein (TBP)-associated factor
Mus musculus ENSMUSG00000078941   adenylate kinase isoenzyme 6
Neospora caninum NCLIV_033190   UPF0101 protein CGI-137, putative
Oryza sativa 4343011   Os07g0412400
Onchocerca volvulus OVOC11249   Adenylate kinase isoenzyme 6 homolog
Plasmodium berghei PBANKA_0202800   adenylate kinase-like protein 1, putative
Plasmodium falciparum PF3D7_0110900   adenylate kinase-like protein 1
Plasmodium knowlesi PKNH_0202600   adenylate kinase-like protein 1, putative
Plasmodium vivax PVX_081255   adenylate kinase-like protein 1, putative
Plasmodium yoelii PY07323   protein ad-004
Saccharomyces cerevisiae YDL166C   Fap7p
Schistosoma japonicum Sjp_0039950   ko:K03133 transcription initiation factor TFIID subunit D7, putative
Schistosoma mansoni Smp_050570   hypothetical protein
Schmidtea mediterranea mk4.029817.00   Adenylate kinase isoenzyme 6
Schmidtea mediterranea mk4.000011.14   Adenylate kinase isoenzyme 6
Trypanosoma brucei gambiense Tbg972.6.3000   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.3210   Adenylate kinase, nuclear
Trypanosoma cruzi TcCLB.509171.47   Adenylate kinase, nuclear
Trypanosoma cruzi TcCLB.507023.280   Adenylate kinase, nuclear
Toxoplasma gondii TGME49_233400   TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor isoform 2 family protein
Theileria parva TP02_0203   hypothetical protein, conserved
Trichomonas vaginalis TVAG_426750   protein ad-004, putative

Essentiality

PF3D7_0110900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.3210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.3210 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.3210 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.3210 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_E02H1.6 Caenorhabditis elegans larval arrest wormbase
CELE_E02H1.6 Caenorhabditis elegans slow growth wormbase
YDL166C Saccharomyces cerevisiae inviable yeastgenome
TGME49_233400 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) Shikimate kinase 162 aa 24.3% 136 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Pviv007536AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pviv007536; Recombinant protein: full-length; Source: P vivax; hypothetical protein, conserved homolog ; Identifier: Pv081255

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_0110900 (Plasmodium falciparum), adenylate kinase-like protein 1
Title for this comment
Comment