Detailed view for PF3D7_0113100

Basic information

TDR Targets ID: 3244
Plasmodium falciparum, surface-associated interspersed protein 1.1 (SURFIN 1.1)
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.1254 | Length (AA): 1555 | MW (Da): 192351 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12879   SICA C-terminal inner membrane domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
422 622 4uos (A) 2 184 21.00 0.033 0.1 0.26266 -0.26
547 701 4tql (A) 9 175 34.00 0.92 0.38 0.294778 0.1
752 1430 4fgv (A) 478 1077 11.00 0 0.99 0.123656 0.49
306 1222 4zt9 (A) 442 1344 22.00 0.24 0.97 0.520505 2.03
469 696 4tql (A) 16 238 19.00 0.00041 0.43 0.343837 -0.39
543 775 4tql (A) 12 238 19.00 0.012 0.11 0.293093 -0.58
547 732 4tql (A) 9 195 30.00 0.81 0.51 0.247594 -0.06
791 1454 4fgv (A) 507 1077 11.00 0 0.81 0.00849167 0.93
1162 1359 4uos (A) 1 183 21.00 0.24 0.16 0.265306 -0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_137681)

Species Accession Gene Product
Plasmodium falciparum PF3D7_0831100   surface-associated interspersed protein 8.1 (SURFIN 8.1)
Plasmodium falciparum PF3D7_1477600   surface-associated interspersed protein 14.1 (SURFIN 14.1)
Plasmodium falciparum PF3D7_0830800   surface-associated interspersed protein 8.2 (SURFIN 8.2)
Plasmodium falciparum PF3D7_0113100   surface-associated interspersed protein 1.1 (SURFIN 1.1)
Plasmodium falciparum PF3D7_0424400   surface-associated interspersed protein 4.2 (SURFIN 4.2)
Plasmodium falciparum PF3D7_0115000   surface-associated interspersed protein 1.3 (SURFIN 1.3)
Plasmodium falciparum PF3D7_0800700   surface-associated interspersed protein 8.3 (SURFIN 8.3)
Plasmodium vivax PVX_132260   unspecified product
Plasmodium vivax PVX_165265   unspecified product
Plasmodium vivax PVX_242295   unspecified product
Plasmodium vivax PVX_166265   unspecified product
Plasmodium vivax PVX_112625   unspecified product
Plasmodium vivax PVX_077195   unspecified product
Plasmodium vivax PVX_128260   unspecified product
Plasmodium vivax PVX_025190   unspecified product
Plasmodium vivax PVX_090285   Pvstp1, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0113100 (Plasmodium falciparum), surface-associated interspersed protein 1.1 (SURFIN 1.1)
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