Detailed view for PF3D7_0114000

Basic information

TDR Targets ID: 3254
Plasmodium falciparum, exported protein family 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 3.9883 | Length (AA): 1463 | MW (Da): 170981 | Paralog Number: 9

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00226   DnaJ domain
PF14308   X-domain of DnaJ-containing

Gene Ontology

Mouse over links to read term descriptions.
GO:0031072   heat shock protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 15 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1090 1176 2ctr (A) 1 85 33.00 0.0000000000016 1 0.53 -0.75
1097 1163 2ctp (A) 8 72 31.00 0.000013 1 0.59 -2.01
35 253 1jad (A) 5 241 17.00 0.19 0.18 0.220892 -0.41
130 347 4tql (A) 9 239 30.00 0.00000059 0.96 0.527209 -1.18
134 405 3gty (X) 105 389 31.00 0.00059 0.12 0.347119 0.45
136 228 3u59 (A) 2 98 28.00 0.95 0.07 0.438768 -1.64
164 441 3sfv (B) 225 526 25.00 0.51 0.37 0.401221 -0.6
169 244 4o9b (A) 263 336 35.00 0.62 0.15 0.649148 -2.68
195 305 3ryc (E) 41 144 38.00 0.64 0.03 0.292071 -0.79
512 647 2oto (A) 67 192 34.00 0.033 0.01 0.52016 -1.72
671 801 2obh (A) 27 159 28.00 0.67 0.33 0.491742 -1.45
1106 1173 1wjz (A) 14 86 37.00 0.29 1 0.56568 -1.35
1109 1172 2ctr (A) 8 69 47.00 0.00072 1 0.732946 -1.65
1110 1172 2ej7 (A) 11 73 32.00 0.015 1 0.646262 -1.99
1111 1172 4rwu (A) 8 65 40.00 0.11 1 0.668579 -2.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Ring, Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Oocyst. Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_140864)

Species Accession Gene Product
Plasmodium falciparum PF3D7_0601300   exported protein family 1
Plasmodium falciparum PF3D7_0701700   exported protein family 1
Plasmodium falciparum PF3D7_1401100   DnaJ protein, putative
Plasmodium falciparum PF3D7_1101800   exported protein family 1
Plasmodium falciparum PF3D7_0324000   exported protein family 1
Plasmodium falciparum PF3D7_0222000   exported protein family 1
Plasmodium falciparum PF3D7_0114000   exported protein family 1
Plasmodium falciparum PF3D7_1253000   gametocyte erythrocyte cytosolic protein
Plasmodium falciparum PF3D7_0631300   exported protein family 1
Plasmodium falciparum PF3D7_0713200   RESA-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0114000 (Plasmodium falciparum), exported protein family 1
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