Detailed view for PF3D7_0210000

Basic information

TDR Targets ID: 3365
Plasmodium falciparum, secretory complex protein 61 gamma subunit
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.2511 | Length (AA): 81 | MW (Da): 9286 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00584   SecE/Sec61-gamma subunits of protein translocation complex

Gene Ontology

Mouse over links to read term descriptions.
GO:0006616   SRP-dependent cotranslational protein targeting to membrane, translocation  
GO:0016020   membrane  
GO:0015450   P-P-bond-hydrolysis-driven protein transmembrane transporter activity  
GO:0015031   protein transport  
GO:0006886   intracellular protein transport  
GO:0006605   protein targeting  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 76 1rh5 (B) 11 61 31.00 0 0.04 0.93 -0.15
14 53 4hr6 (C) 36 78 40.00 0.67 0.35 0.775027 0.76
21 51 3dyt (A) 411 441 29.00 0.98 0.08 0.740216 -0.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, sporozoite, early ring, early trophozoite, late ring, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile early schizont, late schizont. PlasmoDB
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127987)

Species Accession Gene Product
Arabidopsis thaliana AT3G48570   protein transport protein sec61 subunit gamma-3
Arabidopsis thaliana AT5G50460   protein transport protein sec61 subunit gamma-2
Arabidopsis thaliana AT4G24920   transport protein sec61 subunit gamma-1
Babesia bovis BBOV_IV002770   protein transport protein SEC61 gamma subunit, putative
Brugia malayi Bm1_05280   Protein transport protein SEC61 gamma subunit
Caenorhabditis elegans CELE_F32D8.6   Protein EMO-1
Cryptosporidium parvum cgd7_4210   Sec61-gamma subunit of protein translocation complex, putative
Dictyostelium discoideum DDB_G0287777   protein transport protein SEC61 gamma subunit
Drosophila melanogaster Dmel_CG13426   CG13426 gene product from transcript CG13426-RA
Drosophila melanogaster Dmel_CG8860   CG8860 gene product from transcript CG8860-RA
Drosophila melanogaster Dmel_CG14214   Sec61 gamma subunit
Echinococcus granulosus EgrG_001183100   protein transport protein Sec61 subunit
Entamoeba histolytica EHI_048170   Protein transport protein SEC61 gamma subunit, putative
Entamoeba histolytica EHI_038990   Protein transport protein SEC61 gamma subunit, putative
Echinococcus multilocularis EmuJ_001183100   protein transport protein Sec61 subunit
Homo sapiens ENSG00000132432   Sec61 gamma subunit
Leishmania braziliensis LbrM.25.0900   protein transport protein Sec61 gamma subunit, putative
Leishmania donovani LdBPK_251050.1   protein transport protein Sec61 gamma subunit, putative
Leishmania infantum LinJ.25.1050   protein transport protein Sec61 gamma subunit, putative
Leishmania major LmjF.25.1015   protein transport protein Sec61 gamma subunit, putative
Leishmania mexicana LmxM.25.1015   protein transport protein Sec61 gamma subunit, putative
Loa Loa (eye worm) LOAG_11812   protein transporter SEC61 gamma subunit
Mus musculus 102636652   predicted gene 16261
Mus musculus 102634065   protein transport protein Sec61 subunit gamma-like
Mus musculus 102640103   protein transport protein Sec61 subunit gamma-like
Mus musculus 100042561   predicted gene 10177
Mus musculus 102634854   protein transport protein Sec61 subunit gamma-like
Mus musculus 102637269   protein transport protein Sec61 subunit gamma-like
Mus musculus 102640296   predicted gene 12881
Mus musculus ENSMUSG00000078974   SEC61, gamma subunit
Mus musculus 102642071   protein transport protein Sec61 subunit gamma-like
Mus musculus 669751   predicted gene, 17756
Mus musculus 100046078   predicted gene 15266
Mus musculus 102632470   predicted gene, 30534
Mus musculus 100043039   predicted gene 4184
Neospora caninum NCLIV_030910   LRRGT00025, related
Oryza sativa 9271627   Os04g0290466
Oryza sativa 4341707   Os06g0653900
Oryza sativa 4328492   Os02g0178400
Plasmodium berghei PBANKA_0306900   Sec61-gamma subunit of protein translocation complex, putative
Plasmodium falciparum PF3D7_0210000   secretory complex protein 61 gamma subunit
Plasmodium knowlesi PKNH_0411200   Sec61-gamma subunit of protein translocation, putative
Plasmodium vivax PVX_003950   transport protein SEC61 gamma subunit, putative
Plasmodium yoelii PY07642   protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic, putative
Saccharomyces cerevisiae YDR086C   translocon subunit SSS1
Schistosoma japonicum Sjp_0035490   ko:K07342 protein transport protein Sec61 subunit gamma and related proteins, putative
Schistosoma mansoni Smp_036940   sec61 gamma subunit
Schmidtea mediterranea mk4.002119.00   Protein transport protein Sec61 subunit gamma
Schmidtea mediterranea mk4.001245.05   Protein transport protein Sec61 subunit gamma
Trypanosoma brucei gambiense Tbg972.3.640   protein transport protein Sec61 gamma subunit, putative
Trypanosoma brucei Tb927.3.960   protein transport protein Sec61 gamma subunit, putative
Trypanosoma cruzi TcCLB.511871.34   protein transport protein Sec61 gamma subunit, putative
Trypanosoma cruzi TcCLB.511865.54   protein transport protein Sec61 gamma subunit, putative
Toxoplasma gondii TGME49_230380   protein translocation complex, SEC61 gamma subunit
Theileria parva TP03_0370   protein translocation complex, sec61 gamma chain, putative
Trichomonas vaginalis TVAG_136320   sec61 gamma subunit, putative
Trichomonas vaginalis TVAG_291150   sec61 gamma subunit, putative
Trichomonas vaginalis TVAG_279400   sec61 gamma subunit, putative

Essentiality

PF3D7_0210000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.960 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.960 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.960 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.960 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F32D8.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F32D8.6 Caenorhabditis elegans larval arrest wormbase
CELE_F32D8.6 Caenorhabditis elegans slow growth wormbase
YDR086C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0306900 Plasmodium berghei Essential plasmo
TGME49_230380 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_0210000 (Plasmodium falciparum), secretory complex protein 61 gamma subunit
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