Detailed view for PF3D7_0210100

Basic information

TDR Targets ID: 3366
Plasmodium falciparum, 60S ribosomal protein L37ae, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 11.1975 | Length (AA): 96 | MW (Da): 10799 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01780   Ribosomal L37ae protein family

Gene Ontology

Mouse over links to read term descriptions.
GO:0022625   cytosolic large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 82 1jj2 (Y) 11 82 35.00 0 0.62 1.0453 0.98
11 83 1ffk (W) 11 80 40.00 0.0000000000055 0.63 1.01052 1.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127166)

Species Accession Gene Product
Arabidopsis thaliana AT3G10950   putative 60S ribosomal protein L37a-1
Arabidopsis thaliana AT3G60245   zinc-binding ribosomal protein family protein
Babesia bovis BBOV_IV002760   ribosomal protein L37a, putative
Brugia malayi Bm1_52705   60S ribosomal protein L37a
Caenorhabditis elegans CELE_Y48B6A.2   Protein RPL-43
Cryptosporidium parvum cgd3_2250   60S ribosomal protein L37A
Dictyostelium discoideum DDB_G0281093   S60 ribosomal protein L37A
Drosophila melanogaster Dmel_CG5827   Ribosomal protein L37A
Echinococcus granulosus EgrG_000419400   ribosomal protein smL37a
Entamoeba histolytica EHI_008650   60S ribosomal protein L37a, putative
Entamoeba histolytica EHI_148230   60S ribosomal protein L37a, putative
Echinococcus multilocularis EmuJ_000419400   ribosomal protein smL37a
Giardia lamblia GL50803_5517   Ribosomal protein L37a
Homo sapiens 6168   ribosomal protein L37a
Leishmania braziliensis LbrM.35.2130   60S ribosomal protein L37a
Leishmania braziliensis LbrM.33.0880   60S ribosomal protein L37a
Leishmania donovani LdBPK_362020.1   60S ribosomal protein L37a
Leishmania donovani LdBPK_212190.1   60S ribosomal protein L37a, putative
Leishmania infantum LinJ.21.2190   60S ribosomal protein L37a, putative
Leishmania infantum LinJ.36.2020   60S ribosomal protein L37a
Leishmania major LmjF.21.1820   60S ribosomal protein L37a, putative
Leishmania major LmjF.36.1925   60S ribosomal protein L37a
Leishmania mexicana LmxM.36.1925   60S ribosomal protein L37a
Leishmania mexicana LmxM.21.1820   60S ribosomal protein L37a, putative
Loa Loa (eye worm) LOAG_00043   60S ribosomal protein L37a
Mus musculus ENSMUSG00000046330   ribosomal protein L37a
Neospora caninum NCLIV_064540   Ribosomal protein L37a, related
Oryza sativa 4339573   Os05g0557000
Oryza sativa 4325282   Os01g0679700
Plasmodium berghei PBANKA_0307000   60S ribosomal protein L37ae, putative
Plasmodium falciparum PF3D7_0210100   60S ribosomal protein L37ae, putative
Plasmodium knowlesi PKNH_0411100   ribosomal L37ae protein, putative
Plasmodium vivax PVX_003955   60S ribosomal protein L37a, putative
Plasmodium yoelii PY06446   Ribosomal L37ae protein family, putative
Saccharomyces cerevisiae YPR043W   ribosomal 60S subunit protein L43A
Saccharomyces cerevisiae YJR094W-A   ribosomal 60S subunit protein L43B
Schistosoma japonicum Sjp_0075890   ko:K02921 large subunit ribosomal protein L37Ae, putative
Schistosoma mansoni Smp_105320   ribosomal protein smL37a
Schmidtea mediterranea mk4.011282.00   60S ribosomal protein L37a
Schmidtea mediterranea mk4.009377.01   60S ribosomal protein L37a
Trypanosoma brucei gambiense Tbg972.10.7770   60S ribosomal proteins L37, putative
Trypanosoma brucei Tb927.10.6370   60S ribosomal proteins L37, putative
Trypanosoma brucei Tb927.10.220   60S ribosomal protein L37a, putative
Trypanosoma cruzi TcCLB.511145.46   60S ribosomal protein L37a, putative
Trypanosoma cruzi TcCLB.507641.233   ribosomal protein L37, putative
Trypanosoma cruzi TcCLB.504069.56   60S ribosomal protein L37a, putative
Toxoplasma gondii TGME49_325400   ribosomal L37ae family protein
Toxoplasma gondii TGME49_300190   ribosomal protein RPL37A
Theileria parva TP03_0371   60S ribosomal protein L37a, putative
Trichomonas vaginalis TVAG_099020   eukaryotic translation initiation factor 4g, putative
Trichomonas vaginalis TVAG_370820   60S ribosomal protein L37a, putative
Trichomonas vaginalis TVAG_083700   60S ribosomal protein L37a, putative
Trichomonas vaginalis TVAG_197730   50S ribosomal protein l37ae, putative
Trichomonas vaginalis TVAG_283240   50S ribosomal protein l37ae, putative
Trichomonas vaginalis TVAG_124410   50S ribosomal protein l37ae, putative
Trichomonas vaginalis TVAG_212620   60S ribosomal protein L37a, putative
Trichomonas vaginalis TVAG_083720   eukaryotic translation initiation factor 4g, putative

Essentiality

PF3D7_0210100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.6370 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.6370 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.6370 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.6370 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.220 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.220 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.220 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.220 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y48B6A.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y48B6A.2 Caenorhabditis elegans larval arrest wormbase
CELE_Y48B6A.2 Caenorhabditis elegans slow growth wormbase
TGME49_300190 Toxoplasma gondii Probably essential sidik
TGME49_325400 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_0210100 (Plasmodium falciparum), 60S ribosomal protein L37ae, putative
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