Detailed view for PF3D7_0212400

Basic information

TDR Targets ID: 3388
Plasmodium falciparum, conserved Plasmodium membrane protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.4014 | Length (AA): 4091 | MW (Da): 494213 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0008150   biological_process  
GO:0003674   molecular_function  
GO:0003777   microtubule motor activity  
GO:0007018   microtubule-based movement  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 20 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
454 629 4u5a (C) 47 239 26.00 0.68 0.04 0.141521 -0.03
597 891 4hte (A) 255 521 27.00 0.11 0.92 0.15121 0.98
821 1928 3vuo (A) 37 1184 18.00 0 0.98 0.152338 1.68
1689 2537 3s5m (A) 68 970 23.00 0.00047 0.98 0.141229 1.42
2489 2777 4o87 (A) 14 314 28.00 0.099 0.44 -0.0406571 1.03
2727 2999 3n3m (A) 12 287 28.00 0.57 0.32 -0.0201681 1.34
2741 3055 3qg2 (A) 70 417 27.00 0.5 0.78 -0.0513017 2.14
3436 3709 4amc (A) 921 1179 29.00 0.78 0.04 0.126676 0.72
3829 3860 2ena (A) 8 40 13.00 0.55 0 0.0989221 -0.06
107 268 2fds (A) 29 170 33.00 0.25 0.15 0.0285917 1.03
467 636 4u5a (C) 48 239 26.00 0.2 0.24 0.229462 -0.5
490 648 4ux7 (A) 55 231 27.00 0.19 0.78 0.0738529 0.9
604 897 4hte (A) 255 521 27.00 0.42 0.69 0.097096 1.17
857 1888 3vuo (A) 108 1166 23.00 0.00016 0.87 0.158825 1.79
1675 2516 3s5m (A) 68 970 23.00 0.0019 0.93 0.0870381 1.6
2329 3055 3s5m (A) 181 970 22.00 0.0041 0.71 0.0837199 1.79
2468 2753 4o87 (A) 14 314 30.00 0.12 0.79 -0.007874 1.04
2703 2984 3n3m (A) 12 301 29.00 0.9 0.52 0.00714102 1.31
2755 3275 2vkh (A) 10 540 21.00 0.23 0.75 -0.0230065 1.49
3412 3679 4amc (A) 921 1179 29.00 0.045 0.04 0.112694 0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 8 hs, gametocyte, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_153628)

Species Accession Gene Product
Plasmodium berghei PBANKA_0309200   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0212400   conserved Plasmodium membrane protein, unknown function
Plasmodium knowlesi PKNH_0408800   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_002910   hypothetical protein, conserved
Plasmodium yoelii PY05747   hypothetical protein
Plasmodium yoelii PY03353   hypothetical protein

Essentiality

PF3D7_0212400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0309200 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0212400 (Plasmodium falciparum), conserved Plasmodium membrane protein, unknown function
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