pI: 5.2826 |
Length (AA): 448 |
MW (Da): 50990 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
33 | 113 | 1gjx (A) | 2 | 81 | 25.00 | 0 | 1 | 0.42 | 0.02 |
41 | 107 | 2d5d (A) | 79 | 145 | 19.00 | 0.000000000047 | 0.83 | 0.5 | -0.9 |
148 | 188 | 1w85 (I) | 128 | 168 | 22.00 | 0.0000049 | 0.73 | 0.52 | -1.48 |
194 | 447 | 1eaf () | 396 | 637 | 28.00 | 0 | 1 | 0.86 | -1.01 |
31 | 111 | 1k8m (A) | 2 | 82 | 48.00 | 0.000000027 | 1 | 0.754604 | -0.02 |
207 | 443 | 4n72 (A) | 399 | 627 | 28.00 | 0 | 1 | 0.934018 | -0.71 |
212 | 441 | 2ii3 (A) | 195 | 414 | 36.00 | 0 | 1 | 1.02139 | -0.94 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Oocyst, Female Gametocyte. | Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Male Gametocyte. | Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, Ring, Sporozoite. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 16 hs, early trophozoite. | Otto TD PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_128117)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G06850 | dihydrolipoamide branched chain acyltransferase |
Babesia bovis | BBOV_II001300 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor, putative |
Brugia malayi | Bm1_43910 | Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor |
Caenorhabditis elegans | CELE_ZK669.4 | Protein ZK669.4 |
Chlamydia trachomatis | CT_400 | dihydrolipoamide succinyltransferase |
Dictyostelium discoideum | DDB_G0281797 | branched-chain alpha-keto acid dehydrogenase E2 component |
Drosophila melanogaster | Dmel_CG5599 | CG5599 gene product from transcript CG5599-RA |
Escherichia coli | b0115 | pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2 |
Homo sapiens | ENSG00000137992 | dihydrolipoamide branched chain transacylase E2 |
Leishmania braziliensis | LbrM.05.0180 | dihydrolipoamide branched chain transacylase, putative |
Leishmania donovani | LdBPK_050180.1 | dihydrolipoamide branched chain transacylase, putative |
Leishmania infantum | LinJ.05.0180 | dihydrolipoamide branched chain transacylase, putative |
Leishmania major | LmjF.05.0180 | dihydrolipoamide branched chain transacylase, putative |
Leishmania mexicana | LmxM.05.0180 | dihydrolipoamide branched chain transacylase, putative |
Loa Loa (eye worm) | LOAG_15407 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11004 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05887 | hypothetical protein |
Mus musculus | ENSMUSG00000000340 | dihydrolipoamide branched chain transacylase E2 |
Neospora caninum | NCLIV_010320 | dihydrolipoamide branched chain transacylase, E2 subunit, putative |
Oryza sativa | 4327289 | Os01g0314100 |
Plasmodium berghei | PBANKA_0402300 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative |
Plasmodium falciparum | PF3D7_0303700 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex |
Plasmodium knowlesi | PKNH_0839400 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative |
Plasmodium vivax | PVX_119310 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative |
Plasmodium yoelii | PY00503 | Plasmodium vivax PV1H14105_P |
Schmidtea mediterranea | mk4.029456.00 | |
Schmidtea mediterranea | mk4.021231.00 | |
Trypanosoma brucei gambiense | Tbg972.5.5850 | dihydrolipoamide branched chain transacylase, putative |
Trypanosoma brucei | Tb927.5.4330 | dihydrolipoamide branched chain transacylase, putative |
Trypanosoma congolense | TcIL3000_5_4970 | dihydrolipoamide branched chain transacylase, putative |
Trypanosoma cruzi | TcCLB.507601.70 | dihydrolipoamide branched chain transacylase, putative |
Trypanosoma cruzi | TcCLB.510351.90 | dihydrolipoamide branched chain transacylase, putative |
Toxoplasma gondii | TGME49_319920 | 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein |
Theileria parva | TP04_0457 | lipoamide transferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.4330 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.4330 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.4330 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.4330 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0115 | Escherichia coli | essential | goodall |
CELE_ZK669.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_0402300 | Plasmodium berghei | Slow | plasmo |
TGME49_319920 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
16 literature references were collected for this gene.