Detailed view for PF3D7_0504000

Basic information

TDR Targets ID: 4070
Plasmodium falciparum, cation transporting P-ATPase
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.2262 | Length (AA): 2393 | MW (Da): 283038 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00122   E1-E2 ATPase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0005524   ATP binding  
GO:0000166   nucleotide binding  
GO:0008324   cation transmembrane transporter activity  
GO:0006754   ATP biosynthetic process  
GO:0006812   cation transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1480 1658 1q3i (A) 403 587 13.00 0.00000000038 0.54 0.03 -0.38
2128 2384 1v54 (A) 25 305 11.00 0 0.01 0.2 -0.82
246 703 5czz (A) 567 1032 23.00 0.018 0.92 0.160292 1.83
617 687 2hc8 (A) 214 284 27.00 0.04 0.62 0.24187 0.76
621 699 2kij (A) 9 90 35.00 0.13 0.21 0.235913 1.28
1203 1480 3aj6 (A) 7 281 16.00 0.054 0 0.245372 -0.23
1208 1412 1yo8 (A) 738 959 29.00 0.013 0.02 0.179567 0.48
246 702 5czz (A) 567 1032 22.00 0.058 0.75 0.0978832 1.89
616 687 2hc8 (A) 214 285 26.00 0.053 0.62 0.235241 0.78
620 698 2kij (A) 9 90 35.00 0.13 0.21 0.235591 1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile early schizont, early trophozoite, late trophozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, late ring, late schizont. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, Ring, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127048)

Species Accession Gene Product
Babesia bovis BBOV_IV008550   p-type ATPase
Brugia malayi Bm1_35140   E1-E2 ATPase family protein
Candida albicans CaO19.9146   cation translocating P-type ATPase
Candida albicans CaO19.1573   cation translocating P-type ATPase
Caenorhabditis elegans CELE_Y59H11AR.2   Protein CATP-7, isoform C
Caenorhabditis elegans CELE_K07E3.7   Protein CATP-5, isoform A
Caenorhabditis elegans CELE_W08D2.5   Protein CATP-6, isoform B
Cryptosporidium hominis Chro.80246   membrane ATPase
Cryptosporidium hominis Chro.30465   Yor291wp
Cryptosporidium parvum cgd3_4140   P-type ATpase3, 13 transmembrane regions
Cryptosporidium parvum cgd8_2090   cation-transporting ATpase 2 with 8 transmembrane domains
Dictyostelium discoideum DDB_G0279183   P-type ATPase
Dictyostelium discoideum DDB_G0284849   P-type ATPase
Dictyostelium discoideum DDB_G0284955   P-type ATPase
Drosophila melanogaster Dmel_CG32000   CG32000 gene product from transcript CG32000-RH
Echinococcus granulosus EgrG_000675400   cation transporting ATPase 13A3
Echinococcus granulosus EgrG_000572300   cation transporting atpase worm
Echinococcus multilocularis EmuJ_000675400   cation transporting ATPase 13A3
Echinococcus multilocularis EmuJ_000572300   cation transporting atpase worm
Homo sapiens ENSG00000127249   ATPase type 13A4
Homo sapiens ENSG00000159363   ATPase type 13A2
Homo sapiens ENSG00000187527   ATPase type 13A5
Homo sapiens ENSG00000133657   ATPase type 13A3
Loa Loa (eye worm) LOAG_08695   E1-E2 ATPase
Mus musculus ENSMUSG00000038094   ATPase type 13A4
Mus musculus ENSMUSG00000048939   ATPase type 13A5
Mus musculus ENSMUSG00000022533   ATPase type 13A3
Mus musculus ENSMUSG00000036622   ATPase type 13A2
Neospora caninum NCLIV_041450   cDNA FLJ39191 fis, clone OCBBF2004669, highly similar to Homo sapiens ATPase type 13A4 (ATP13A4), mRNA, related
Plasmodium berghei PBANKA_1103600   cation transporting P-ATPase, putative
Plasmodium falciparum PF3D7_0516100   cation-transporting ATPase 1
Plasmodium falciparum PF3D7_0504000   cation transporting P-ATPase
Plasmodium knowlesi PKNH_1029600   cation transporting P-ATPase, putative
Plasmodium vivax PVX_097770   P-type ATPase, putative
Plasmodium yoelii PY04047   P-Type ATPase
Saccharomyces cerevisiae YOR291W   Ypk9p
Schistosoma japonicum Sjp_0052580   Probable cation-transporting ATPase K07E3.7, putative
Schistosoma japonicum Sjp_0203040   expressed protein
Schistosoma japonicum Sjp_0056850   Probable cation-transporting ATPase K07E3.7, putative
Schistosoma japonicum Sjp_0037010   ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative
Schistosoma japonicum Sjp_0037020   Probable cation-transporting ATPase W08D2.5, putative
Schistosoma japonicum Sjp_0017260   Probable cation-transporting ATPase W08D2.5, putative
Schistosoma japonicum Sjp_0316170   expressed protein
Schistosoma japonicum Sjp_0056910   Conserved hypothetical protein
Schistosoma mansoni Smp_175360.2   cation-transporting atpase worm
Schistosoma mansoni Smp_172750   type V p-type atpase isoform
Schistosoma mansoni Smp_128460   type V p-type atpase isoform
Schistosoma mansoni Smp_175370   type V p-type atpase isoform
Schistosoma mansoni Smp_175360.1   cation-transporting atpase worm
Schmidtea mediterranea mk4.005149.00  
Schmidtea mediterranea mk4.002291.03   Probable cation-transporting ATPase 13A2
Schmidtea mediterranea mk4.002291.02  
Schmidtea mediterranea mk4.002291.01  
Schmidtea mediterranea mk4.009667.03  
Schmidtea mediterranea mk4.009933.00  
Theileria parva TP01_0922   P-type ATPase, putative

Essentiality

PF3D7_0504000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1103600 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_0504000 (Plasmodium falciparum), cation transporting P-ATPase
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