Detailed view for LbrM.27.1390

Basic information

TDR Targets ID: 432869
Leishmania braziliensis, ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Source Database / ID: 

pI: 7.5377 | Length (AA): 574 | MW (Da): 65500 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00443   Ubiquitin carboxyl-terminal hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0036459   GO:thiol-dependent ubiquitinyl hydrolase activity  

GO:0016579   protein deubiquitination  
GO:0006511   ubiquitin-dependent protein catabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 135 2xze (A) 6 142 17.00 0 0.53 0.434023 -0.35
213 574 2f1z (A) 177 520 31.00 0 1 0.734862 0.78
246 574 2y6e (A) 302 922 27.00 0 1 0.918471 -0.38
247 574 2y6e (A) 303 922 33.00 0 1 0.968629 -0.55
247 572 3i3t (A) 213 555 36.00 0 1 0.925144 -0.25

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127431)

Species Accession Gene Product
Brugia malayi Bm1_51515   Ubiquitin carboxyl-terminal hydrolase family protein
Candida albicans CaO19.7207   ubiquitin-specific protease
Caenorhabditis elegans CELE_E01B7.1   Protein E01B7.1
Cryptosporidium hominis Chro.20366   ubiquitin specific protease 66
Cryptosporidium parvum cgd2_3450   ubiquitin C-terminal hydrolase of the cysteine proteinase fold
Drosophila melanogaster Dmel_CG14619   CG14619 gene product from transcript CG14619-RH
Drosophila melanogaster Dmel_CG5798   UBPY ortholog
Echinococcus granulosus EgrG_000729100   ubiquitin specific protease 41
Echinococcus granulosus EgrG_000957900   ubiquitin carboxyl terminal hydrolase 8
Echinococcus granulosus EgrG_000337400   Peptidase C19 ubiquitin carboxyl terminal hydrolase 2
Entamoeba histolytica EHI_137730   ubiquitin carboxyl-terminal hydrolase domain containing protein
Echinococcus multilocularis EmuJ_000957900   ubiquitin carboxyl terminal hydrolase 8
Echinococcus multilocularis EmuJ_000337400   Peptidase C19, ubiquitin carboxyl terminal hydrolase 2
Echinococcus multilocularis EmuJ_000729100   ubiquitin specific protease 41
Giardia lamblia GL50803_16090   Ubiquitin carboxyl-terminal hydrolase 4
Homo sapiens 9101   ubiquitin specific peptidase 8
Homo sapiens ENSG00000036672   ubiquitin specific peptidase 2
Leishmania braziliensis LbrM.27.1390   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania donovani LdBPK_271170.1   ubiquitin carboxyl-terminal hydrolase, putative
Leishmania infantum LinJ.27.1170   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania major LmjF.27.1270   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Leishmania mexicana LmxM.27.1270   ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Loa Loa (eye worm) LOAG_00066   hypothetical protein
Mus musculus ENSMUSG00000032010   ubiquitin specific peptidase 2
Mus musculus ENSMUSG00000027363   ubiquitin specific peptidase 8
Saccharomyces cerevisiae YDR069C   Doa4p
Saccharomyces cerevisiae YER144C   Ubp5p
Schistosoma japonicum Sjp_0213580   expressed protein
Schistosoma japonicum Sjp_0301630   ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative
Schistosoma japonicum Sjp_0130570   Ubiquitin carboxyl-terminal hydrolase 8, putative
Schistosoma japonicum Sjp_0116190   hypothetical protein
Schistosoma japonicum Sjp_0016030   IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing
Schistosoma japonicum Sjp_0092320   Ubiquitin carboxyl-terminal hydrolase 8, putative
Schistosoma japonicum Sjp_0306850   IPR015063,Domain of unknown function DUF1873,domain-containing
Schistosoma mansoni Smp_152000   ubiquitin-specific peptidase 8 (C19 family)
Schistosoma mansoni Smp_175520   ubiquitin-specific peptidase 2 (C19 family)
Schmidtea mediterranea mk4.008068.02  
Schmidtea mediterranea mk4.015183.01  
Schmidtea mediterranea mk4.008263.05  
Schmidtea mediterranea mk4.010073.00   Ubiquitin carboxyl-terminal hydrolase
Schmidtea mediterranea mk4.008263.04   Ubiquitin carboxyl-terminal hydrolase
Schmidtea mediterranea mk4.010073.01  
Schmidtea mediterranea mk4.005269.02   Ubiquitin carboxyl-terminal hydrolase 8
Schmidtea mediterranea mk4.008263.03  
Schmidtea mediterranea mk4.004821.03  
Trypanosoma brucei gambiense Tbg972.11.2100   ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
Trypanosoma brucei Tb927.11.1930   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma congolense TcIL3000_0_47810   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma cruzi TcCLB.508355.380   ubiquitin carboxyl-terminal hydrolase, putative
Trypanosoma cruzi TcCLB.508357.40   ubiquitin carboxyl-terminal hydrolase, putative
Trichomonas vaginalis TVAG_143300   conserved hypothetical protein
Trichomonas vaginalis TVAG_143290   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase
Trichomonas vaginalis TVAG_019670   Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase

Essentiality

LbrM.27.1390 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.46.0014 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.46.0014 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.46.0014 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.46.0014 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_E01B7.1 Caenorhabditis elegans larval arrest wormbase
CELE_E01B7.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ubiquitin specific peptidase 2 Compounds References
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LbrM.27.1390 (Leishmania braziliensis), ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative
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