Detailed view for TcCLB.504191.19

Basic information

TDR Targets ID: 44911
Trypanosoma cruzi, sterol 24-c-methyltransferase, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 8.2409 | Length (AA): 161 | MW (Da): 18228 | Paralog Number: 498

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02353   Mycolic acid cyclopropane synthetase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 161 1wxx (A) 114 264 15.00 0.000026 0.13 1.02 0.69
87 160 1ri5 (A) 47 120 26.00 0 0.97 0.84 -0.93
99 158 1l3i (A) 28 86 20.00 0.000001 0.37 0.71 -1.25
2 158 3ocj (A) 13 171 18.00 0 0.23 1.04396 0.63
90 146 3ccf (A) 24 79 29.00 0.0071 0.37 0.643937 0.17
99 142 3gcz (A) 68 116 41.00 0.91 0.13 0.471692 0.56
103 158 1ri5 (A) 63 118 34.00 0 0.88 0.868626 -1.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) decreased (PATO:0000468) amastigote (BTO:0000062) inferred from in vitro culture assay (ECO:0000182) Trypanosoma cruzi 912702  
Annotator: millerja@u.washington.edu. Comment: See Table 2 in referenced publication for structure of Compound 3a. References: 15273104

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.504191.19 (Trypanosoma cruzi), sterol 24-c-methyltransferase, putative
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