Detailed view for PF3D7_0729200

Basic information

TDR Targets ID: 477
Plasmodium falciparum, 1-cys peroxiredoxin
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.7583 | Length (AA): 240 | MW (Da): 28124 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08534   Redoxin

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0016491   oxidoreductase activity  
GO:0016209   antioxidant activity  
GO:0006979   response to oxidative stress  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 172 2bmx (A) 8 170 17.00 0 1 1.16 -1.1
19 173 1xiy (A) 18 180 95.00 0 1 2.14 -2.18
59 238 4d73 (A) 59 238 99.00 0 1 1.9813 -2
90 235 1nm3 (A) 22 162 40.00 0 1 1.16263 -0.93

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1XIY:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4D73:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 16 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, Oocyst, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 48 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 40 hs, Sporozoite, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_127915)

Species Accession Gene Product
Arabidopsis thaliana AT3G52960   peroxiredoxin-2E
Arabidopsis thaliana AT1G65970   thioredoxin-dependent peroxidase 2
Arabidopsis thaliana AT1G60740   peroxiredoxin-2D
Candida albicans CaO19.8054   one of three genes similar to fungal peroxisomal PMP20 and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase
Candida albicans CaO19.10278   one of three genes similar to fungal peroxisomal PMP20 and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase
Candida albicans CaO19.2762   one of three genes similar to fungal peroxisomal PMP20 and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase
Candida albicans CaO19.424   one of three genes similar to fungal peroxisomal PMP20 and to S. cerevisiae AHP1 (YLR109W) alkyl hydroperoxide reductase
Dictyostelium discoideum DDB_G0285741   hypothetical protein
Drosophila melanogaster Dmel_CG7217   Peroxiredoxin 5
Homo sapiens ENSG00000126432   peroxiredoxin 5
Mus musculus 54683   peroxiredoxin 5
Neospora caninum NCLIV_014020   Peroxiredoxin-2E-1 (EC 1.11.1.15), related
Oryza sativa 4341570   Os06g0625500
Oryza sativa 4328586   Os02g0192700
Oryza sativa 4325511   Os01g0675100
Plasmodium berghei PBANKA_0213300   1-cys peroxiredoxin, putative
Plasmodium falciparum PF3D7_0729200   1-cys peroxiredoxin
Plasmodium knowlesi PKNH_0213800   1-cys peroxiredoxin, putative
Plasmodium vivax PVX_081760   peroxiredoxin, putative
Plasmodium yoelii PY01475   hypothetical protein
Saccharomyces cerevisiae YLR109W   Ahp1p
Schmidtea mediterranea mk4.000295.04   Peroxiredoxin-5, mitochondrial
Toxoplasma gondii TGME49_286630   redoxin domain-containing protein

Essentiality

PF3D7_0729200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0213300 Plasmodium berghei Dispensable plasmo
TGME49_286630 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium vivax 1763   48945   59943   547983   572016   572017  
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 12144348 15701514
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 1763   48945   59943   547983   572016   572017  
Annotator: saralph@unimelb.edu.au. Comment: 012/Mar/09. References: 12144348 15701514

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_0729200 (Plasmodium falciparum), 1-cys peroxiredoxin
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