Detailed view for TcCLB.504069.70

Basic information

TDR Targets ID: 48329
Trypanosoma cruzi, vacuolar ATP synthase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.6555 | Length (AA): 196 | MW (Da): 19809 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00137   ATP synthase subunit C

Gene Ontology

Mouse over links to read term descriptions.
GO:0033179   proton-transporting V-type ATPase, V0 domain  
GO:0033177   proton-transporting two-sector ATPase complex, proton-transporting domain  
GO:0015078   hydrogen ion transmembrane transporter activity  
GO:0015991   ATP hydrolysis coupled proton transport  
GO:0015986   ATP synthesis coupled proton transport  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)
Phagosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
42 183 2bl2 (A) 14 152 24.00 0 0.12 1.12 -1.87
120 184 3zk1 (A) 12 79 37.00 0.00013 0.01 0.422733 1.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126803)

Species Accession Gene Product
Arabidopsis thaliana AT4G38920   vacuolar-type H(+)-ATPase C3
Arabidopsis thaliana AT1G75630   V-type proton ATPase proteolipid subunit c4
Arabidopsis thaliana AT4G34720   vacuolar H+-pumping ATPase C1
Arabidopsis thaliana AT1G19910   VACUOLAR-TYPE H+ ATPASE C2
Arabidopsis thaliana AT2G16510   ATPase, F0/V0 complex, subunit C protein
Babesia bovis BBOV_II002740   proteolipid subunit c, putative
Brugia malayi Bm1_44375   Vacuolar ATP synthase 16 kDa proteolipid subunit, putative
Candida albicans CaO19_6538   hypothetical protein
Candida albicans CaO19.13307   vacuolar ATPase subunit c, identical to C.tropicalis Vma3p (AAA03446)
Candida albicans CaO19.13891   ATP synthase subunit C
Candida albicans CaO19.5886   vacuolar ATPase subunit c, identical to C.tropicalis Vma3p (AAA03446)
Candida albicans CaO19.6538   hydrogen-transporting ATPase
Caenorhabditis elegans CELE_R10E11.2   Protein VHA-2
Caenorhabditis elegans CELE_Y38F2AL.4   Protein VHA-3
Cryptosporidium hominis Chro.10063   vacuolar ATP synthase 16 kDa proteolipid subunit (V-ATPase 16 kDa proteolipid subunit)
Cryptosporidium hominis Chro.10062   vacuolar ATP synthetase
Cryptosporidium parvum cgd1_540   vacuolar ATP synthase subunit, possible signal peptide
Cryptosporidium parvum cgd1_520   vacuolar ATP synthetase subunit
Dictyostelium discoideum DDB_G0274381   vacuolar ATPase proteolipid subunit
Drosophila melanogaster Dmel_CG9013   Vacuolar H[+] ATPase 16kD subunit 4
Drosophila melanogaster Dmel_CG32090   Vacuolar H[+] ATPase 16kD subunit 3
Drosophila melanogaster Dmel_CG3161   Vacuolar H[+] ATPase 16kD subunit 1
Echinococcus granulosus EgrG_000866800   Vacuolar ATP synthase 16 kDa proteolipid
Echinococcus granulosus EgrG_001052800   Vacuolar ATP synthase 16 kDa proteolipid
Entamoeba histolytica EHI_059840   V-type ATPase, C subunit, putative
Echinococcus multilocularis EmuJ_000866800   Vacuolar ATP synthase 16 kDa proteolipid
Echinococcus multilocularis EmuJ_001052800   Vacuolar ATP synthase 16 kDa proteolipid
Giardia lamblia GL50803_8559   Vacuolar ATP synthase 16 kDa proteolipid subunit
Giardia lamblia GL50803_10530   Vacuolar ATP synthase 16 kDa proteolipid subunit
Homo sapiens ENSG00000185883   ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Leishmania braziliensis LbrM.33.0860   vacuolar ATP synthase, putative
Leishmania braziliensis LbrM.33.0850   vacuolar ATP synthase, putative
Leishmania braziliensis LbrM.23.0150   vacuolar type h ATPase subunit, putative
Leishmania donovani LdBPK_212160.1   vacuolar ATP synthase, putative
Leishmania donovani LdBPK_230150.1   vacuolar type h+ ATPase subunit, putative
Leishmania infantum LinJ.21.2160   vacuolar ATP synthase, putative
Leishmania infantum LinJ.21.2170   vacuolar ATP synthase, putative
Leishmania infantum LinJ.23.0150   vacuolar type h ATPase subunit, putative
Leishmania major LmjF.23.0130   vacuolar type h ATPase subunit, putative
Leishmania major LmjF.21.1790   vacuolar ATP synthase, putative
Leishmania major LmjF.21.1800   vacuolar ATP synthase, putative
Leishmania mexicana LmxM.21.1800   vacuolar ATP synthase, putative
Leishmania mexicana LmxM.21.1790   vacuolar ATP synthase, putative
Leishmania mexicana LmxM.23.0130   vacuolar type h ATPase subunit, putative
Loa Loa (eye worm) LOAG_01760   vacuolar ATP synthase proteolipid subunit
Mus musculus ENSMUSG00000024121   ATPase, H+ transporting, lysosomal V0 subunit C
Neospora caninum NCLIV_049080   hypothetical protein
Oryza sativa 4351612   Os12g0168900
Oryza sativa 4329623   Os02g0550100
Oryza sativa 4337563   Os05g0106100
Oryza sativa 4349890   Os11g0169900
Plasmodium berghei PBANKA_1234000   V-type proton ATPase 16 kDa proteolipid subunit, putative
Plasmodium falciparum PF3D7_0519200   V-type proton ATPase 16 kDa proteolipid subunit
Plasmodium knowlesi PKNH_1013900   V-type proton ATPase 16 kDa proteolipid subunit, putative
Plasmodium vivax PVX_080285   V-type proton ATPase 16 kDa proteolipid subunit, putative
Plasmodium yoelii PY06066   V-type ATPase, C subunit, putative
Saccharomyces cerevisiae YEL027W   H(+)-transporting V0 sector ATPase subunit C
Saccharomyces cerevisiae YPL234C   H(+)-transporting V0 sector ATPase subunit c'
Schistosoma japonicum Sjp_0011840   ko:K02155 V-type H+-transporting ATPase 16kDa proteolipid subunit, putative
Schistosoma japonicum Sjp_0053370   similar to Vacuolar ATP synthase 16 kDa proteolipid subunit, putative
Schistosoma mansoni Smp_004310   vacuolar ATP synthase proteolipid subunit 1 2 3
Schistosoma mansoni Smp_062890   vacuolar ATP synthase proteolipid subunit 1 2 3
Schmidtea mediterranea mk4.000625.00   Putative vacuolar ATP synthase proteolipid subunit 1, 2,3
Trypanosoma brucei gambiense Tbg972.10.110   vacuolar ATP synthase, putative
Trypanosoma brucei Tb927.8.2100   vacuolar ATP synthase 16 kDa proteolipid subunit, putative
Trypanosoma brucei Tb927.10.200   vacuolar ATP synthase, putative
Trypanosoma congolense TcIL3000_8_2100   vacuolar ATP synthase 16 kDa proteolipid subunit, putative
Trypanosoma congolense TcIL3000_10_70   vacuolar ATP synthase, putative
Trypanosoma cruzi TcCLB.504069.70   vacuolar ATP synthase, putative
Trypanosoma cruzi TcCLB.511145.50   vacuolar ATP synthase, putative
Theileria parva TP04_0317   vacuolar ATPase subunit
Trichomonas vaginalis TVAG_462950   vacuolar ATP synthase proteolipid subunit 1, 2, 3, putative
Trichomonas vaginalis TVAG_492780   vacuolar ATP synthase proteolipid subunit, putative
Trichomonas vaginalis TVAG_412690   vacuolar ATP synthase proteolipid subunit, putative
Trichomonas vaginalis TVAG_136250   vacuolar ATP synthase proteolipid subunit, putative

Essentiality

TcCLB.504069.70 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.2100 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.2100 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.2100 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.8.2100 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.200 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.200 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.200 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.200 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R10E11.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_R10E11.2 Caenorhabditis elegans larval arrest wormbase
CELE_R10E11.2 Caenorhabditis elegans slow growth wormbase
CELE_R10E11.2 Caenorhabditis elegans sterile wormbase
CELE_Y38F2AL.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y38F2AL.4 Caenorhabditis elegans larval arrest wormbase
CELE_Y38F2AL.4 Caenorhabditis elegans larval lethal wormbase
CELE_Y38F2AL.4 Caenorhabditis elegans slow growth wormbase
PBANKA_1234000 Plasmodium berghei Essential plasmo
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Saccharomyces cerevisiae H(+)-transporting V0 sector ATPase subunit c' Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0017 1 1
0.0017 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

36 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcCLB.504069.70 (Trypanosoma cruzi), vacuolar ATP synthase, putative
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