Detailed view for PF3D7_1219700

Basic information

TDR Targets ID: 5240
Plasmodium falciparum, raf kinase inhibitor
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.6301 | Length (AA): 190 | MW (Da): 21576 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01161   Phosphatidylethanolamine-binding protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 189 1wpx (B) 507 717 24.00 0 1 1.25 -0.81
4 188 2gzq (A) 5 189 74.00 0 1 2.03 -2.21
3 189 2r77 (A) 19 205 99.99 0 1 2.27421 -2

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 2GZQ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 2R77:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Oocyst, Ring, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Male Gametocyte. Otto TD Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_127642)

Species Accession Gene Product
Arabidopsis thaliana AT1G18100   protein MOTHER of FT and TF 1
Brugia malayi Bm1_41005   OV-16 antigen precursor
Candida albicans CaO19.9530   putative lipid binding protein
Candida albicans CaO19.1974   cell cycle regulator
Caenorhabditis elegans CELE_F40A3.3   Protein F40A3.3, isoform B
Dictyostelium discoideum DDB_G0283803   phosphatidylethanolamine-binding protein PEBP
Drosophila melanogaster Dmel_CG17919   CG17919 gene product from transcript CG17919-RA
Drosophila melanogaster Dmel_CG6180   CG6180 gene product from transcript CG6180-RA
Drosophila melanogaster Dmel_CG10298   CG10298 gene product from transcript CG10298-RA
Homo sapiens ENSG00000089220   phosphatidylethanolamine binding protein 1
Loa Loa (eye worm) LOAG_11720   OV-16 antigen
Mus musculus 76400   phosphatidylethanolamine binding protein 2
Mus musculus ENSMUSG00000032959   phosphatidylethanolamine binding protein 1
Neospora caninum NCLIV_002850   hypothetical protein
Oryza sativa 4326145   Os01g0111600
Oryza sativa 4341107   Os06g0498800
Oryza sativa 4341272   Os06g0552900
Plasmodium berghei PBANKA_1434900   raf kinase inhibitor, putative
Plasmodium falciparum PF3D7_1219700   raf kinase inhibitor
Plasmodium knowlesi PKNH_1438900   raf kinase inhibitor, putative
Plasmodium vivax PVX_123630   raf kinase inhibitor, putative
Plasmodium vivax PVX_235290   unspecified product
Plasmodium yoelii PY01852   putative phosphatidylethanolamine-binding protein
Saccharomyces cerevisiae YLR179C   hypothetical protein
Saccharomyces cerevisiae YLR178C   Tfs1p
Toxoplasma gondii TGME49_207930   phosphatidylethanolamine-binding protein

Essentiality

PF3D7_1219700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_207930 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Pviv009166AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pviv009166; Recombinant protein: full-length; Source: P vivax; Phosphatidylethanolamine-binding protein ; Identifier: Pv123630

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1219700 (Plasmodium falciparum), raf kinase inhibitor
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