pI: 6.9727 |
Length (AA): 415 |
MW (Da): 46482 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 335 | 6aqz (A) | 1 | 333 | 49.00 | 0 | 1 | 1.43163 | -0.88 |
21 | 335 | 4e5y (A) | 7 | 321 | 59.00 | 0 | 1 | 1.50444 | -0.89 |
291 | 365 | 4dun (A) | 39 | 126 | 41.00 | 0.78 | 0.15 | 0.167923 | 1.96 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129198)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G73250 | GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase 1 |
Arabidopsis thaliana | AT1G17890 | putative GDP-L-fucose synthase 2 |
Brugia malayi | Bm1_11280 | GDP-L-fucose synthetase |
Caenorhabditis elegans | CELE_R01H2.5 | Protein GER-1 |
Dictyostelium discoideum | DDB_G0270184 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3495 | GDP-4-keto-6-deoxy-D-mannose 3,5-epimerase/4-reductase |
Escherichia coli | b2052 | bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase/GDP-4-dehydro-6-L-deoxygalactose reductase |
Echinococcus granulosus | EgrG_000476900 | GDP L fucose synthase |
Echinococcus multilocularis | EmuJ_000476900 | GDP L fucose synthase |
Homo sapiens | ENSG00000104522 | tissue specific transplantation antigen P35B |
Loa Loa (eye worm) | LOAG_04263 | hypothetical protein |
Mus musculus | ENSMUSG00000022570 | tissue specific transplantation antigen P35B |
Mycobacterium tuberculosis | Rv1512 | Probable nucleotide-sugar epimerase EpiA |
Neospora caninum | NCLIV_014250 | NAD-dependent epimerase/dehydratase, related |
Oryza sativa | 4341699 | Os06g0652400 |
Onchocerca volvulus | OVOC13467 |
|
Plasmodium berghei | PBANKA_1212400 | GDP-L-fucose synthase, putative |
Plasmodium falciparum | PF3D7_1014000 | GDP-L-fucose synthase |
Plasmodium knowlesi | PKNH_0813800 | GDP-L-fucose synthase, putative |
Plasmodium vivax | PVX_094915 | GDP-L-fucose synthase, putative |
Plasmodium yoelii | PY01921 | transplantation antigen p35b-related |
Schistosoma japonicum | Sjp_0050740 | ko:K02377 GDP-L-fucose synthase [EC1.1.1.271], putative |
Schistosoma mansoni | Smp_104720 | NAD dependent epimerase/dehydratase |
Schmidtea mediterranea | mk4.013198.00 | Probable GDP-L-fucose synthase |
Schmidtea mediterranea | mk4.004837.00 | Probable GDP-L-fucose synthase |
Trypanosoma brucei gambiense | Tbg972.11.15620 | GDP-L-fucose synthetase, putative |
Trypanosoma brucei | Tb927.11.13990 | GDP-L-fucose synthetase |
Trypanosoma congolense | TcIL3000.11.14350 | GDP-L-fucose synthetase, putative |
Trypanosoma cruzi | TcCLB.511727.300 | GDP-L-fucose synthetase, putative |
Toxoplasma gondii | TGME49_286220 | GDP-L-fucose synthetase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.5560 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5560 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5560 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.5560 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2052 | Escherichia coli | non-essential | goodall |
PBANKA_1212400 | Plasmodium berghei | Dispensable | plasmo |
TGME49_286220 | Toxoplasma gondii | Probably non-essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.