Detailed view for EgrG_000826200

Basic information

TDR Targets ID: 593740
Echinococcus granulosus, peripheral plasma membrane protein CASK
Source Database / ID:  GeneDB

pI: 5.8205 | Length (AA): 931 | MW (Da): 104647 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00595   PDZ domain (Also known as DHR or GLGF)
PF00625   Guanylate kinase
PF02828   L27 domain
PF07653   Variant SH3 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0005515   protein binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 449 3hx4 (A) 40 463 26.00 0 1 0.692577 0.26
5 343 3c0g (B) 5 324 67.00 0 1 1.10842 -0.58
361 407 1rso (B) 88 134 51.00 0.00036 0.54 0.559383 0.28
419 474 1zl8 (B) 107 159 43.00 0.000081 0.14 0.30605 1.21
466 594 5v6t (B) 89 213 22.00 0 1 0.334861 0.19
481 592 3egg (C) 455 580 27.00 0.044 1 0.375601 -0.49
511 930 4wsi (A) 252 674 37.00 0 1 0.630428 0.77
512 598 1kwa (A) 487 573 76.00 0 1 1.08375 -1.54
535 592 2awx (A) 345 402 29.00 0.68 1 0.518199 -0.93

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131953)

Species Accession Gene Product
Brugia malayi Bm1_33725   Peripheral plasma membrane protein CASK
Brugia malayi Bm1_33715   CASK
Caenorhabditis elegans CELE_F17E5.1   Protein LIN-2, isoform B
Drosophila melanogaster Dmel_CG6703   CASK ortholog
Echinococcus granulosus EgrG_000826200   peripheral plasma membrane protein CASK
Echinococcus granulosus EgrG_001091800   55 kDa erythrocyte membrane protein
Echinococcus multilocularis EmuJ_001091800   55 kDa erythrocyte membrane protein
Echinococcus multilocularis EmuJ_000826200   peripheral plasma membrane protein CASK
Homo sapiens ENSG00000147044   calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Loa Loa (eye worm) LOAG_08350   peripheral plasma membrane protein CASK
Mus musculus ENSMUSG00000031012   calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Onchocerca volvulus OVOC2817  
Schistosoma japonicum Sjp_0099520   IPR000719,Protein kinase,domain-containing
Schistosoma japonicum Sjp_0019370   ko:K06103 calcium/calmodulin-dependent serine protein kinase, putative
Schistosoma japonicum Sjp_0095530   ko:K06103 calcium/calmodulin-dependent serine protein kinase, putative
Schistosoma japonicum Sjp_0102420   IPR000719,Protein kinase,domain-containing
Schistosoma japonicum Sjp_0101920   Peripheral plasma membrane protein CASK, putative
Schistosoma japonicum Sjp_0019390   Selenoprotein O, putative
Schistosoma japonicum Sjp_0074900   Calcium/calmodulin-dependent protein kinase, putative
Schistosoma japonicum Sjp_0123510   Peripheral plasma membrane protein CASK, putative
Schistosoma japonicum Sjp_0010060   Peripheral plasma membrane protein CASK, putative
Schistosoma japonicum Sjp_0134100   Selenoprotein O, putative
Schistosoma mansoni Smp_131690   MAGUK homolog
Schmidtea mediterranea mk4.019391.01  
Schmidtea mediterranea mk4.001239.06  
Schmidtea mediterranea mk4.012221.00  
Schmidtea mediterranea mk4.019259.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Xenopus laevis Aurora kinase B-A 361 aa 25.9% 293 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 23.8% 315 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 24.8% 330 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 8 411 aa 23.1% 334 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 27.5% 295 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 22.3% 328 aa Compounds References
Patiria pectinifera Cdc2 300 aa 26.3% 312 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 27.8% 295 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 26.8% 295 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 25.4% 319 aa Compounds References
Rattus norvegicus Glycogen synthase kinase-3 beta 420 aa 25.1% 386 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 24.7% 178 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 25.1% 299 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 23.5% 319 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 27.9% 319 aa Compounds References
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 419 aa 25.1% 386 aa Compounds References
Sus scrofa Glycogen synthase kinase 3 beta 420 aa 25.1% 386 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0008 0.5 0.5
0.0037 1 1
0.0023 0.5 0.5
0.0012 0.5 0.5
0.0018 0.5 0.5
0.0011 1 1
0.0061 0.6883 0.6883
0.0093 0.8828 0
0.0027 1 1
0.0063 1 1
0.0064 0.3377 0.5563
0.0007 0.5 0.5
0.0267 0.2508 0.3386
0.0059 1 1
0.0059 1 1
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0069 0.3067 0.3067
0.0039 0.5 0.5
0.0098 0.3242 0.2282
0.0033 0.5 0.5
0.0081 0.5 0.5
0.0063 0.7244 0
0.0044 0.2612 0.2895
0.0062 0.6935 0.733
0.0016 0.5 0.5
0.0007 0.5 0.5
0.0066 0.3101 0.7874
0.0081 1 1
0.0059 1 1
0.0091 1 1
0.0012 0.5 0.5
0.0026 0.5 0.5
0.0067 0.5 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5
0.0042 0.5 0.5
0.0032 0.5 0.5
0.0029 0.5 0.5
0.0088 0.4477 0.4477
0.0022 0.5 0.5
0.0092 1 1
0.0056 1 1
0.0033 1 1
0.0004 0.5 0.5
0.0039 0.9485 0.9402
0.0036 0.5 0.5
0.0007 0.5 0.5
0.0016 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000826200 (Echinococcus granulosus), peripheral plasma membrane protein CASK
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