Detailed view for PF3D7_1330400

Basic information

TDR Targets ID: 73
Plasmodium falciparum, ER lumen protein retaining receptor 1, putative, unspecified product
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.2821 | Length (AA): 284 | MW (Da): 32806 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00810   ER lumen protein retaining receptor

Gene Ontology

Mouse over links to read term descriptions.
GO:0005046   KDEL sequence binding  
GO:0016021   integral to membrane  
GO:0005783   endoplasmic reticulum  
GO:0046923   ER retention sequence binding  
GO:0006886   intracellular protein transport  
GO:0006621   protein retention in ER lumen  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite. Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Female Gametocyte. Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_133624)

Species Accession Gene Product
Arabidopsis thaliana AT2G21190   putative ER lumen protein retaining receptor
Arabidopsis thaliana AT4G38790   ER lumen protein retaining receptor family protein
Arabidopsis thaliana AT1G19970   ER lumen protein retaining receptor
Arabidopsis thaliana AT1G75760   ER lumen protein retaining receptor family protein
Babesia bovis BBOV_III003440   membrane protein, putative
Cryptosporidium hominis Chro.10334   ER lumen protein retaining receptor-like protein
Cryptosporidium parvum cgd1_3010   ER lumen protein retaining receptor 1; KDEL recpetor 1
Neospora caninum NCLIV_048350   ER lumen protein retaining receptor, related
Oryza sativa 4347687   Os09g0534200
Oryza sativa 4346239   Os08g0548200
Plasmodium berghei PBANKA_1345400   ER lumen protein retaining receptor 1, putative
Plasmodium falciparum PF3D7_1330400   ER lumen protein retaining receptor 1, putative, unspecified product
Plasmodium knowlesi PKNH_1270000   ER lumen protein retaining receptor 1, putative
Plasmodium vivax PVX_082460   ER lumen protein retaining receptor 1, putative
Plasmodium yoelii PY06403   ER lumen protein retaining receptor-like protein, putative
Toxoplasma gondii TGME49_224205   ER lumen protein retaining receptor, putative
Theileria parva TP03_0344   ER lumen protein retaining receptor, putative

Essentiality

PF3D7_1330400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1345400 Plasmodium berghei Essential plasmo
TGME49_224205 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1330400 (Plasmodium falciparum), ER lumen protein retaining receptor 1, putative, unspecified product
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