Detailed view for PF3D7_1331600

Basic information

TDR Targets ID: 78
Plasmodium falciparum, protein tyrosine phosphatase-like protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.796 | Length (AA): 228 | MW (Da): 26387 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04387   Protein tyrosine phosphatase-like protein, PTPLA

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 207 1xio (A) 2 222 17.00 0.19 0.05 0.899549 0.01
48 135 4jq6 (A) 94 213 34.00 0.3 0.25 0.446765 1.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, early schizont, early trophozoite, late schizont, late trophozoite, Female Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, Oocyst. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 16 hs, early ring, Sporozoite, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Ring. Zanghi G
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_127323)

Species Accession Gene Product
Arabidopsis thaliana AT5G59770   Protein-tyrosine phosphatase-like, PTPLA
Arabidopsis thaliana AT5G10480   very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase PASTICCINO 2
Babesia bovis BBOV_III006410   membrane protein, putative
Brugia malayi Bm1_32340   Protein tyrosine phosphatase-like protein, PTPLA containing protein
Candida albicans CaO19.5156   one of two adjacent potential PTPLA genes (protein tyrosine phosphatase-like protein)
Candida albicans CaO19_5157   hypothetical protein
Candida albicans CaO19.5157   one of two adjacent potential PTPLA genes (protein tyrosine phosphatase-like protein)
Candida albicans CaO19_5156   hypothetical protein
Candida albicans CaO19.12624   one of two adjacent potential PTPLA genes (protein tyrosine phosphatase-like protein)
Candida albicans CaO19.12623   one of two adjacent potential PTPLA genes (protein tyrosine phosphatase-like protein)
Caenorhabditis elegans CELE_T15B7.2   Protein HPO-8
Cryptosporidium hominis Chro.30252   similar to NM_072339 T15B7
Cryptosporidium parvum cgd3_2150   protein phosphatase, signal peptide, 2-6 transmembrane domain protein
Dictyostelium discoideum DDB_G0278113   hypothetical protein
Drosophila melanogaster Dmel_CG6746   CG6746 gene product from transcript CG6746-RA
Echinococcus granulosus EgrG_000677300   protein tyrosine phosphatase protein
Entamoeba histolytica EHI_110570   protein tyrosine phosphatase, putative
Echinococcus multilocularis EmuJ_000677300   protein tyrosine phosphatase protein
Giardia lamblia GL50803_7512   Protein tyrosine phosphatase-like protein
Homo sapiens 201562   protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
Homo sapiens ENSG00000165996   protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
Leishmania braziliensis LbrM.05.0270   protein tyrosine phosphatase, putative
Leishmania donovani LdBPK_050280.1   protein tyrosine phosphatase, putative
Leishmania infantum LinJ.05.0280   protein tyrosine phosphatase, putative
Leishmania major LmjF.05.0280   protein tyrosine phosphatase, putative
Leishmania mexicana LmxM.05.0280   protein tyrosine phosphatase, putative
Loa Loa (eye worm) LOAG_01917   hypothetical protein
Mus musculus ENSMUSG00000035376   protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b
Mus musculus ENSMUSG00000063275   protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a
Neospora caninum NCLIV_055210   hypothetical protein
Oryza sativa 4339019   Os05g0460800
Oryza sativa 4335343   Os04g0271200
Oryza sativa 4324518   Os01g0150200
Plasmodium berghei PBANKA_1346500   protein tyrosine phosphatase-like protein
Plasmodium falciparum PF3D7_1331600   protein tyrosine phosphatase-like protein, putative
Plasmodium knowlesi PKNH_1268900   protein tyrosine phosphatase-like protein, putative
Plasmodium vivax PVX_082515   protein tyrosine phosphatase-like protein, putative
Saccharomyces cerevisiae YJL097W   enoyl-CoA hydratase PHS1
Schistosoma japonicum Sjp_0305420   ko:K10703 3-hydroxy acyl-CoA dehydratase, putative
Schistosoma mansoni Smp_022700.2   protein tyrosine phosphatase-like protein
Schistosoma mansoni Smp_022700.5   protein tyrosine phosphatase-like protein
Schmidtea mediterranea mk4.005463.01  
Trypanosoma brucei gambiense Tbg972.10.12870   protein tyrosine phosphatase, putative
Trypanosoma brucei Tb927.10.10610   protein tyrosine phosphatase, putative
Trypanosoma congolense TcIL3000_10_8930   protein tyrosine phosphatase, putative
Trypanosoma cruzi TcCLB.511635.40   protein tyrosine phosphatase, putative
Toxoplasma gondii TGME49_311290   protein tyrosine phosphatase family protein, ptpla protein

Essentiality

PF3D7_1331600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.10610 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.10610 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.10610 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.10610 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T15B7.2 Caenorhabditis elegans adult lethal wormbase
CELE_T15B7.2 Caenorhabditis elegans larval arrest wormbase
CELE_T15B7.2 Caenorhabditis elegans larval lethal wormbase
CELE_T15B7.2 Caenorhabditis elegans slow growth wormbase
YJL097W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1346500 Plasmodium berghei Dispensable plasmo
TGME49_311290 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1331600 (Plasmodium falciparum), protein tyrosine phosphatase-like protein, putative
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