Detailed view for PF3D7_0104300

Basic information

TDR Targets ID: 829557
Plasmodium falciparum, ubiquitin carboxyl-terminal hydrolase 1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 8.7365 | Length (AA): 3499 | MW (Da): 416039 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0036459   GO:thiol-dependent ubiquitinyl hydrolase activity  

GO:0006511   ubiquitin-dependent protein catabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 21 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
282 407 1yo8 (A) 802 938 30.00 0.28 0.07 0.20361 0.09
804 1046 3qki (A) 49 338 29.00 0.74 0.87 0.140048 0.56
1164 1314 2ap3 (A) 30 192 25.00 0.77 0.07 0.183755 -0.24
1610 1810 4tql (A) 11 213 11.00 0.45 0.02 0.181945 -0.52
1969 2642 4n5c (E) 69 816 16.00 0.12 0.88 0.126526 0.85
2796 2853 2cot (A) 5 62 12.00 0.85 0 0.137076 -0.4
2993 3074 2kmk (A) 1 82 7.00 0.0075 0 0.0919353 -0.38
3038 3490 4fk5 (A) 8 469 22.00 0 1 0.116366 0.64
3167 3490 5cvn (B) 32 366 26.00 0 1 0.191498 0.12
3170 3490 2y6e (A) 302 924 22.00 0 1 0.0856405 -0.13
3171 3490 5cvn (B) 36 366 29.00 0.000000000011 1 0.219055 0.52
789 1031 3qki (A) 49 338 29.00 0.5 0.53 0.100952 0.62
1149 1299 2ap3 (A) 30 192 25.00 0.74 0.07 0.184354 -0.24
1625 2578 3vuo (A) 4 1082 25.00 0.057 0.8 0.186502 1.59
1839 2001 4u5a (C) 48 231 17.00 0.85 0.01 0.180523 -0.84
2061 2213 1wmz (A) 1 138 8.00 0.00035 0.02 -0.149268 0.69
3016 3450 4fk5 (A) 8 469 23.00 0 1 0.0971589 0.67
3112 3448 3n3k (A) 757 1108 25.00 0 1 0.138827 -0.03
3127 3374 3ihp (A) 323 601 17.00 0.00000019 0.93 -0.013903 0.77
3131 3450 5cvn (B) 36 366 29.00 0.0000000000055 1 0.220212 0.52
3131 3450 5cvn (B) 36 366 27.00 0 1 0.223912 0.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 16 hs, Oocyst, Ring, Sporozoite, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Female Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_146935)

Species Accession Gene Product
Plasmodium berghei PBANKA_0208800   ubiquitin carboxyl-terminal hydrolase 1, putative
Plasmodium falciparum PF3D7_0104300   ubiquitin carboxyl-terminal hydrolase 1, putative
Plasmodium knowlesi PKNH_0209200   ubiquitin carboxyl-terminal hydrolase 1, putative
Plasmodium vivax PVX_081540   ubiquitin carboxyl-terminal hydrolase 1, putative
Plasmodium yoelii PY06943   hypothetical protein
Plasmodium yoelii PY01242   Ubiquitin carboxyl-terminal hydrolase family 2, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0104300 (Plasmodium falciparum), ubiquitin carboxyl-terminal hydrolase 1, putative
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