Detailed view for TVAG_577900

Basic information

TDR Targets ID: 878246
Trichomonas vaginalis, conserved hypothetical protein
Source Database / ID: 

pI: 5.8799 | Length (AA): 140 | MW (Da): 15280 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00609   Diacylglycerol kinase accessory domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004143   diacylglycerol kinase activity  
GO:0007205   activation of protein kinase C activity  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128654)

Species Accession Gene Product
Arabidopsis thaliana AT5G63770   diacylglycerol kinase 2
Arabidopsis thaliana AT5G07920   diacylglycerol kinase1
Caenorhabditis elegans CELE_F54G8.2   Protein DGK-3
Cryptosporidium parvum cgd3_2630   diacylglycerol kinase
Dictyostelium discoideum DDB_G0277223   diacylglycerol kinase
Drosophila melanogaster Dmel_CG34361   Diacyl glycerol kinase
Entamoeba histolytica EHI_045610   diacylglycerol kinase, putative
Homo sapiens ENSG00000058866   diacylglycerol kinase, gamma 90kDa
Homo sapiens ENSG00000065357   diacylglycerol kinase, alpha 80kDa
Homo sapiens ENSG00000136267   diacylglycerol kinase, beta 90kDa
Leishmania donovani LdBPK_355060.1   diacylglycerol kinase-like protein
Leishmania infantum LinJ.35.5060   diacylglycerol kinase-like protein
Leishmania major LmjF.35.5370   diacylglycerol kinase-like protein
Leishmania mexicana LmxM.34.5370   diacylglycerol kinase-like protein
Mus musculus ENSMUSG00000022861   diacylglycerol kinase, gamma
Mus musculus ENSMUSG00000025357   diacylglycerol kinase, alpha
Mus musculus ENSMUSG00000036095   diacylglycerol kinase, beta
Neospora caninum NCLIV_015910   hypothetical protein
Oryza sativa 4352615   Os12g0576900
Oryza sativa 9266342   Os03g0425300
Schmidtea mediterranea mk4.000309.02   Diacylglycerol kinase alpha
Schmidtea mediterranea mk4.000309.01  
Trypanosoma cruzi TcCLB.507257.80   diacylglycerol kinase-like protein, putative
Trypanosoma cruzi TcCLB.510329.290   diacylglycerol kinase-like protein, putative
Toxoplasma gondii TGME49_239250   diacylglycerol kinase, putative
Trichomonas vaginalis TVAG_416130   diacylglycerol kinase, putative
Trichomonas vaginalis TVAG_215120   diacylglycerol kinase, zeta, iota, putative
Trichomonas vaginalis TVAG_326490   diacylglycerol kinase, putative
Trichomonas vaginalis TVAG_175800   diacylglycerol kinase, zeta, iota, putative
Trichomonas vaginalis TVAG_577900   conserved hypothetical protein
Trichomonas vaginalis TVAG_588420   diacylglycerol kinase, epsilon, putative

Essentiality

TVAG_577900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_239250 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_577900 (Trichomonas vaginalis), conserved hypothetical protein
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