pI: 7.4141 |
Length (AA): 229 |
MW (Da): 26307 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 226 | 6e12 (A) | 2 | 216 | 21.00 | 0 | 1 | 1.18793 | -0.32 |
18 | 219 | 3msq (A) | 11 | 214 | 28.00 | 0.0000024 | 0.7 | 1.117 | 0.04 |
18 | 224 | 3msq (A) | 11 | 219 | 24.00 | 0 | 1 | 1.18113 | -0.38 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128661)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G03690 | ubiquinone biosynthesis protein COQ4-like protein |
Brugia malayi | Bm1_53390 | Ubiquinone biosynthesis protein COQ4 homolog |
Candida albicans | CaO19.10526 | Protein involved in biosynthesis of coenzyme Q |
Candida albicans | CaO19.3008 | Protein involved in biosynthesis of coenzyme Q |
Caenorhabditis elegans | CELE_T03F1.2 | Protein COQ-4 |
Cryptosporidium hominis | Chro.10049 | ubiquinone biosynthesis protein COQ4 (Coenzyme Q biosynthesis protein 4 ) (CGI-92) |
Cryptosporidium parvum | cgd1_380 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0292620 | coenzyme Q biosynthesis protein |
Drosophila melanogaster | Dmel_CG32174 | CG32174 gene product from transcript CG32174-RD |
Homo sapiens | ENSG00000167113 | coenzyme Q4 |
Leishmania braziliensis | LbrM.09.1490 | ubiquinone biosynthesis protein-like protein, putative |
Leishmania donovani | LdBPK_091500.1 | ubiquinone biosynthesis protein-like protein, putative |
Leishmania infantum | LinJ.09.1500 | ubiquinone biosynthesis protein-like protein, putative |
Leishmania major | LmjF.09.1430 | ubiquinone biosynthesis protein-like protein, putative |
Leishmania mexicana | LmxM.09.1430 | ubiquinone biosynthesis protein-like protein, putative |
Loa Loa (eye worm) | LOAG_00995 | hypothetical protein |
Mus musculus | ENSMUSG00000026798 | coenzyme Q4 homolog (yeast) |
Neospora caninum | NCLIV_007060 | ubiquinone biosynthesis protein COQ4, putative |
Oryza sativa | 4338019 | Os05g0188800 |
Oryza sativa | 4337378 | Os04g0674200 |
Plasmodium berghei | PBANKA_0935400 | ubiquinone biosynthesis protein COQ4, putative |
Plasmodium falciparum | PF3D7_1112200 | ubiquinone biosynthesis protein COQ4, putative |
Plasmodium knowlesi | PKNH_0909900 | ubiquinone biosynthesis protein COQ4, putative |
Plasmodium vivax | PVX_091260 | ubiquinone biosynthesis protein COQ4, putative |
Plasmodium yoelii | PY05764 | putative ubiquinone biosynthesis protein |
Saccharomyces cerevisiae | YDR204W | Coq4p |
Schistosoma japonicum | Sjp_0114790 | Ubiquinone biosynthesis protein COQ4 homolog, putative |
Schistosoma mansoni | Smp_001430 | ubiquinone biosynthesis protein |
Schmidtea mediterranea | mk4.000567.03 | Ubiquinone biosynthesis protein coq-4, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.11.15160 | ubiquinone biosynthesis protein-like protein, putative |
Trypanosoma brucei | Tb927.11.13580 | ubiquinone biosynthesis protein-like protein |
Trypanosoma congolense | TcIL3000.11.13910 | ubiquinone biosynthesis protein-like protein |
Trypanosoma cruzi | TcCLB.506753.170 | ubiquinone biosynthesis protein-like protein, putative |
Trypanosoma cruzi | TcCLB.510357.70 | ubiquinone biosynthesis protein-like protein, putative |
Toxoplasma gondii | TGME49_275980 | coenzyme q (ubiquinone) biosynthesis protein coq4 protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.5180 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.5180 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.5180 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb11.01.5180 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_0935400 | Plasmodium berghei | Essential | plasmo |
TGME49_275980 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.