Detailed view for OVOC1257

Basic information

TDR Targets ID: 988457
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.0545 | Length (AA): 497 | MW (Da): 55763 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 158 4ik8 (A) 296 448 26.00 0.000000000069 1 1.14494 -0.08
19 158 3ox6 (A) 16 166 26.00 0 1 1.12012 -0.67
23 157 2obh (A) 26 166 28.00 0.000000016 1 1.20353 -1.14
23 88 5z1q (A) 22 92 24.00 0.65 1 0.840887 -2.09
96 174 2aao (A) 24 115 35.00 0.13 0.99 0.74692 -0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130698)

Species Accession Gene Product
Arabidopsis thaliana AT1G02330   hypothetical protein
Brugia malayi Bm1_04585   Hepatocellular carcinoma-associated antigen 59 family protein
Caenorhabditis elegans CELE_T23G11.4   Protein T23G11.4
Dictyostelium discoideum DDB_G0268774   hypothetical protein
Drosophila melanogaster Dmel_CG7974   CG7974 gene product from transcript CG7974-RB
Echinococcus granulosus EgrG_000205600   Hepatocellular carcinoma associated antigen 59
Echinococcus multilocularis EmuJ_000205600   Hepatocellular carcinoma associated antigen 59
Homo sapiens ENSG00000136819   chromosome 9 open reading frame 78
Loa Loa (eye worm) LOAG_11127   hypothetical protein
Loa Loa (eye worm) LOAG_11128   hypothetical protein
Mus musculus 227707   cDNA sequence BC005624
Neospora caninum NCLIV_024100   hypothetical protein
Oryza sativa 4332947   Os03g0374100
Onchocerca volvulus OVOC1257  
Onchocerca volvulus OVOC1256  
Plasmodium berghei PBANKA_1331500   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1468200   conserved protein, unknown function
Plasmodium knowlesi PKNH_1213000   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_117055   hypothetical protein, conserved
Plasmodium yoelii PY02060   Arabidopsis thaliana At1g02330/T6A9_12-related
Schistosoma japonicum Sjp_0202930   IPR010756,Hepatocellular carcinoma-associated antigen 59,domain-containing
Schistosoma mansoni Smp_035150   hypothetical protein
Schmidtea mediterranea mk4.003381.02  
Toxoplasma gondii TGME49_263860   hypothetical protein

Essentiality

OVOC1257 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_263860 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
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Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Aspergillus fumigatus Chitinase 433 aa 27.8% 360 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1659 1 1
0.0141 1 1
0.0232 0.3763 0.5888
0.0209 1 1
0.0082 0.5065 1
0.0188 1 1
0.0253 0.6022 1
0.0235 1 1
0.0116 0.2943 0.8379
0.0232 0.3066 1
0.1815 1 1
0.0118 0.8277 1
0.0365 1 1
0.064 0.893 0.8927
0.0122 1 1
0.0117 1 1
0.0117 0.8279 1
0.1105 0.8721 1
0.0932 0.8211 0.8208
0.0114 0.3415 1
0.150623 0.753721 1
0.0144 1 1
0.0203 0.2978 1
0.0608 1 1
0.0125 0.6877 1
0.0233 0.3897 0.7976
0.0258 0.2671 0.7745
0.0236 0.5972 1
0.0365 1 1
0.0135 0.3342 0.8776
0.012 0.5292 1
0.0376 1 1
0.0121 0.2983 1
0.0467 1 1
0.0115 0.2914 0.2705
0.2201 1 1
0.0747 0.8316 0.8316
0.0489 0.9689 1
0.0125 0.2989 1
0.0234 0.2938 0.999
0.0252 0.6007 1
0.0118 0.2642 1
0.0114 0.3415 1
0.0133 0.3123 1
0.0246 0.2792 1
0.152 1 1
0.1114 1 1
0.1216 1 1
0.087 0.8993 0.8993
0.0119 0.3039 0.7415
0.0233 0.2639 0.4835
0.0118 0.2626 1
0.179 1 1
0.0144 1 1
0.0244 1 1
0.012 1 1
0.0241 0.4144 1
0.1509 0.4701 1
0.0613 1 1
0.0474 0.6341 1
0.0119 0.3134 1
0.0238 0.6282 1
0.0122 0.2851 1
0.1027 0.9377 0.9376
0.0124 0.296 1
0.0144 1 1
0.0115 0.2914 0.2705
0.0121 0.3157 1
0.1174 0.3365 1
0.0141 1 1
0.0118 0.2826 1
0.0144 0.2777 0.4832
0.0651 0.8289 0.8289
0.0118 0.5016 1
0.0237 0.3775 1
0.0119 0.3039 0.7415
0.0122 1 1
0.177 1 1
0.0277 1 1
0.0141 1 1
0.0241 1 1
0.1504 1 1
0.0261 1 1
0.0144 1 1
0.0142 0.9361 0.9361
0.0387 0.383 1
0.0122 1 1
0.0123 1 1
0.0115 0.3079 1
0.1504 1 1
0.0739 0.9112 1
0.0141 1 1
0.151 1 1
0.0232 0.3066 1
0.0277 0.5859 1
0.0144 1 1
0.0246 0.5552 0.9462
0.0118 0.2683 1
0.012 1 1
0.0203 0.2978 1
0.0119 0.2991 0.4873
0.0141 1 1
0.0479 0.4712 1
0.0362 0.9094 1
0.0116 1 1
0.0117 0.2848 1
0.0115 0.4108 1
0.1125 0.4298 0.7507
0.1605 1 1
0.0116 0.3223 0.8021
0.0886 0.9063 0.9061
0.0164 0.7351 0.7331
0.0241 0.4144 1
0.0362 1 1
0.0237 0.312 1
0.0104 0.8176 0.7819
0.0116 0.4971 0.5895
0.037 1 1
0.012 0.607 1
0.1517 0.4731 1
0.0237 1 1
0.0088 0.6092 0.5548
0.0638 0.7668 0.7668
0.0131 0.3118 1
0.0244 0.257 0.7146
0.0104 0.8176 0.7819
0.0144 1 1
0.0371 0.8601 1
0.1042 0.2544 0.4397
0.0144 1 1
0.0122 0.2884 0.8487
0.0479 0.4712 1
0.0144 1 1
0.0599 1 1
0.0144 0.7622 0.5777
0.0245 0.328 1
0.0139 0.3972 1
0.073 1 1
0.0124 0.6245 1
0.0237 0.4284 1
0.041 0.9011 1
0.1042 0.2544 0.4397
0.1232 0.2563 1
0.0728 0.7652 0.7652
0.0233 0.2639 0.4835
0.0116 0.2529 1
0.0144 1 1
0.0106 0.6249 1
0.0116 1 1
0.0117 1 1
0.086 1 1
0.0122 0.5932 0.5932
0.1775 1 1
0.0144 1 1
0.0675 0.6963 0.6957
0.1126 0.9775 0.9775
0.012 0.3233 0.827
0.0848 0.8292 0.8289
0.1329 1 1
0.0121 0.3198 1
0.0237 0.6297 1
0.0122 1 1
0.0155589 1 0.5
0.0479 1 1
0.1125 0.4298 0.7507
0.1154 1 1
0.0362 0.846 1
0.0242 0.8465 1
0.0144 1 1
0.0254 0.2721 0.7577
0.1042 0.2544 0.4397
0.1248 0.3878 1
0.0111 0.6556 1
0.0144 1 1
0.1343 1 1
0.0251 1 1
0.177 1 1
0.0116 1 1
0.0249 1 1
0.0126 1 1
0.1042 0.2544 0.4397
0.0115 1 1
0.0144 1 1
0.0249 1 1
0.0111 1 1
0.0246 0.5301 1
0.0121 0.3198 1
0.1232 0.2563 1
0.1105 1 1
0.0249 0.3924 1
0.0117 1 1
0.0116 0.6275 1
0.0126 1 1

Assayability

Assay information

  • ChEMBL
  • Inhibition of Onchocerca volvulus chitinase by fluorescence based assay
  • ChEMBL
  • Inhibition of Onchocerca volvulus L3 larvae chitinase using 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as a profluorescent substrate after 10 mins by fluorometric analysis
  • ChEMBL
  • Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 mins by microplate reader analysis
  • ChEMBL
  • Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate at 10 uM after 10 mins by microplate reader analysis
  • ChEMBL
  • Competitive inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 mins by microplate reader analysis
  • ChEMBL
  • Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as release of 4-methylumbelliferone at 10 uM measured for 10 mins by fluorescence assay
  • ChEMBL
  • Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as release of 4-methylumbelliferone measured for 10 mins by fluorescence assay
  • ChEMBL
  • Competitive inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as release of 4-methylumbelliferone measured for 10 mins by Dixon plot analysis

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC1257 (Onchocerca volvulus),
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