Detailed information for compound 1009714

Basic information

Technical information
  • TDR Targets ID: 1009714
  • Name: (3S)-6-[(2R)-2-amino-2-phenylethyl]-8-(2-fluo rophenyl)-3-phenyl-2,3-dihydro-[1,3]thiazolo[ 2,3-f]pyrimidine-5,7-dione
  • MW: 459.535 | Formula: C26H22FN3O2S
  • H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](c1ccccc1)Cn1c(=O)c(c2ccccc2F)c2n(c1=O)[C@H](CS2)c1ccccc1
  • InChi: 1S/C26H22FN3O2S/c27-20-14-8-7-13-19(20)23-24(31)29(15-21(28)17-9-3-1-4-10-17)26(32)30-22(16-33-25(23)30)18-11-5-2-6-12-18/h1-14,21-22H,15-16,28H2/t21-,22+/m0/s1
  • InChiKey: IVIDZBGALXXDPN-FCHUYYIVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S)-6-[(2R)-2-amino-2-phenyl-ethyl]-8-(2-fluorophenyl)-3-phenyl-2,3-dihydrothiazolo[2,3-f]pyrimidine-5,7-dione
  • (3S)-6-[(2R)-2-amino-2-phenylethyl]-8-(2-fluorophenyl)-3-phenyl-2,3-dihydrothiazolo[2,3-f]pyrimidine-5,7-dione
  • (3S)-6-[(2R)-2-amino-2-phenyl-ethyl]-8-(2-fluorophenyl)-3-phenyl-2,3-dihydrothiazolo[2,3-f]pyrimidine-5,7-quinone
  • (3S)-6-[(2R)-2-amino-2-phenyl-ethyl]-8-(2-fluorophenyl)-3-phenyl-2,3-dihydro-[1,3]thiazolo[2,3-f]pyrimidine-5,7-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0008 0.0016
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0114 0.0167
Giardia lamblia Neurogenic locus notch-like protein 0.0022 0.0019 0.0184
Loa Loa (eye worm) hypothetical protein 0.016 0.0406 0.1137
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0069 0.0152 0.0426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.0885 0.273
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0154 0.0389 0.109
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0114 0.0319
Schistosoma mansoni adenoreceptor 0.0055 0.0114 0.0111
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0033 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0166 0.048
Brugia malayi topoisomerase 0.002 0.0015 0.0029
Loa Loa (eye worm) hypothetical protein 0.0074 0.0166 0.0465
Brugia malayi beta-lactamase family protein 0.0074 0.0166 0.0453
Entamoeba histolytica DNA repair protein RAD51, putative 0.0023 0.0024 0.0118
Schistosoma mansoni acetylcholine receptor-related 0.0154 0.0389 0.0387
Schistosoma mansoni tyrosine kinase 0.0021 0.0016 0.0014
Brugia malayi nuclear hormone receptor 0.0019 0.0012 0.0022
Trypanosoma brucei mitotic cyclin 6 0.0093 0.0218 0.0576
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.0022 0.0022 0.0061
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0094 0.0264
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN) 0.0023 0.0023 0.0063
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.0006
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0012 0.0034
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.1291 0.3572 0.3571
Giardia lamblia hypothetical protein 0.0022 0.0019 0.0184
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.0015 0.0038
Brugia malayi G-protein coupled receptor 0.0055 0.0114 0.0306
Brugia malayi G-protein coupled receptor 0.0055 0.0114 0.0306
Loa Loa (eye worm) hypothetical protein 0.0045 0.0085 0.0238
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0314 0.0837 0.1229
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0114 0.0319
Giardia lamblia Hypothetical protein 0.0039 0.0067 0.0726
Giardia lamblia Histone acetyltransferase GCN5 0.0076 0.0172 0.1919
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0068 0.0148 0.0415
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0015 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0008 0.0016
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0013 0.0115
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0314 0.0837 0.2333
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.0885 0.273
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0114 0.0167
Onchocerca volvulus 0.0314 0.0837 0.3316
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit beta 0.0068 0.0148 0.0454
Loa Loa (eye worm) hypothetical protein 0.0911 0.2508 0.7019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0012 0.0022
Entamoeba histolytica Ran family GTPase 0.0047 0.0089 0.0836
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0166 0.0431
Schistosoma mansoni cyclins 0.0039 0.0067 0.0064
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0114 0.0111
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0331 0.0885 0.9585
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0314 0.0837 0.2343
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.116 0.3206 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0314 0.0837 0.2343
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0042 0.0105
Brugia malayi DKFZp564C0469 protein 0.002 0.0015 0.0029
Loa Loa (eye worm) hypothetical protein 0.0074 0.0166 0.0465
Echinococcus multilocularis nAChR subunit 0.0314 0.0837 0.1229
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Onchocerca volvulus 0.0055 0.0114 0.0423
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0021 0.0016 0.0024
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0015 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0349 0.0978
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0012 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0067 0.0169
Echinococcus multilocularis NCK adaptor protein 0.0017 0.0007 0.0011
Giardia lamblia G2/mitotic-specific cyclin B 0.0093 0.0218 0.2441
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0042 0.0118
Brugia malayi acetyltransferase, GNAT family protein 0.0283 0.075 0.2088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0349 0.0978
Echinococcus granulosus histone acetyltransferase KAT2B 0.0083 0.0191 0.0536
Brugia malayi hypothetical protein 0.0154 0.0389 0.1079
Onchocerca volvulus 0.0055 0.0114 0.0423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0114 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) RGS-3 protein 0.002 0.0014 0.0039
Entamoeba histolytica hypothetical protein 0.0051 0.0102 0.0982
Schistosoma mansoni nAChR subunit 0.0314 0.0837 0.0834
Loa Loa (eye worm) fli-1 protein 0.0214 0.0559 0.1564
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0012 0.0022
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0114 0.0111
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0014 0.0021
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0114 0.0167
Echinococcus multilocularis cyclins 0.0039 0.0067 0.0098
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0114 0.0167
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0314 0.0837 0.2333
Echinococcus multilocularis expressed conserved protein 0.0188 0.0486 0.0714
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.1291 0.3572 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0014 0.0021
Brugia malayi putative neuropeptide receptor 0.0055 0.0114 0.0306
Brugia malayi Dopamine receptor 0.0055 0.0114 0.0306
Schistosoma mansoni inositol monophosphatase 0.0036 0.006 0.0057
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.081 0.2227 0.2225
Echinococcus granulosus cyclin b3 0.0039 0.0067 0.0187
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0014 0.0027
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0095 0.0092
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0114 0.0319
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.003 0.0042 0.0136
Schistosoma mansoni cyclin B3 0.0039 0.0067 0.0064
Onchocerca volvulus 0.0055 0.0114 0.0423
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0044 0.0111
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.1291 0.3572 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0218 0.061
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0154 0.0389 0.1079
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0039
Brugia malayi RNA, U transporter 1 0.018 0.0462 0.1281
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0154 0.0389 0.1079
Trichomonas vaginalis cyclins, putative 0.0039 0.0067 0.0169
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0079 0.018 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0012 0.0022
Onchocerca volvulus 0.0154 0.0389 0.1526
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0015 0.0022
Echinococcus granulosus g protein coupled receptor 0.0055 0.0114 0.0319
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0014 0.0021
Schistosoma mansoni growth factor receptor-bound protein 0.0017 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0176
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0014 0.0011
Echinococcus multilocularis protein dispatched 1 0.0098 0.0234 0.0343
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0014 0.0039
Trypanosoma cruzi CYC2-like cyclin, putative 0.0093 0.0218 0.0576
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0074 0.0166 0.0465
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0039
Schistosoma mansoni tumor necrosis factor receptor related 0.0044 0.0083 0.008
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0063 0.0168
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0114 0.0319
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.1291 0.3572 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0114 0.0319
Echinococcus granulosus tyrosine protein kinase Src42A 0.0079 0.018 0.0503
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0039 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0193 0.0499 0.1398
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0063 0.0168
Schistosoma mansoni biogenic amine receptor 0.0055 0.0114 0.0111
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0166 0.0465
Schistosoma mansoni microtubule-associated protein tau 0.0781 0.2145 0.2143
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0068 0.0148 0.0408
Echinococcus multilocularis dna repair protein rad51 1 0.0023 0.0024 0.0035
Echinococcus multilocularis cyclins 0.0039 0.0067 0.0098
Loa Loa (eye worm) hypothetical protein 0.0201 0.052 0.1456
Onchocerca volvulus 0.0055 0.0114 0.0423
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Onchocerca volvulus 0.0055 0.0114 0.0423
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0015 0.0006
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0119
Schistosoma mansoni hypothetical protein 0.0071 0.0157 0.0154
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0114 0.0167
Brugia malayi Tyrosine-protein kinase abl-1 0.0021 0.0016 0.0033
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.006 0.0146
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0079 0.018 0.0264
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0114 0.0111
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0911 0.2508 0.3683
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0114 0.0111
Echinococcus granulosus death domain containing protein 0.0029 0.004 0.0112
Echinococcus granulosus GPCR family 2 0.0193 0.0499 0.1398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0114 0.0111
Trypanosoma cruzi cyclin, putative 0.0093 0.0218 0.0576
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Mycobacterium tuberculosis Conserved protein 0.0344 0.0922 0.2871
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0135 0.0132
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0015 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0012 0.0034
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0314 0.0837 0.0834
Brugia malayi MH2 domain containing protein 0.0116 0.0285 0.0785
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0124
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0314 0.0837 0.2343
Schistosoma mansoni cyclin B 0.0093 0.0218 0.0215
Toxoplasma gondii microneme protein, putative 0.0037 0.0063 0.0168
Onchocerca volvulus 0.0314 0.0837 0.3316
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.1291 0.3572 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0013 0.0032
Loa Loa (eye worm) TK protein kinase 0.0069 0.0152 0.0426
Onchocerca volvulus 0.0055 0.0114 0.0423
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0014 0.0027
Schistosoma mansoni amine GPCR 0.0055 0.0114 0.0111
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.006 0.0131
Brugia malayi hypothetical protein 0.002 0.0015 0.0029
Schistosoma mansoni ran 0.0047 0.0089 0.0086
Toxoplasma gondii kringle domain-containing protein 0.0045 0.0085 0.0231
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0007 0.0008
Brugia malayi hypothetical protein 0.002 0.0015 0.0029
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0033 0.0062
Echinococcus granulosus histone acetyltransferase KAT2B 0.0275 0.0727 0.2036
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0114 0.0319
Trichomonas vaginalis cyclin B, putative 0.0093 0.0218 0.0642
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0114 0.0167
Onchocerca volvulus 0.0037 0.0063 0.0219
Schistosoma mansoni coup transcription factor 0.0019 0.0012 0.001
Echinococcus multilocularis cyclins 0.0039 0.0067 0.0098
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0012 0.0018
Echinococcus multilocularis microtubule associated protein 2 0.0781 0.2145 0.315
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0012 0.001
Echinococcus multilocularis lamin 0.0031 0.0044 0.0065
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0079 0.018 0.0264
Echinococcus granulosus lamin 0.0031 0.0044 0.0124
Toxoplasma gondii microneme protein MIC4 0.0037 0.0063 0.0168
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0053 0.0149
Brugia malayi neuropeptide F receptor 0.0055 0.0114 0.0306
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0068 0.0148 0.0408
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0028 0.008
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0039 0.0067 0.0187
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0193 0.0499 0.0733
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0063 0.0176
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0114 0.0306
Brugia malayi larval opioid receptor 0.0055 0.0114 0.0306
Brugia malayi intermediate filament protein 0.0031 0.0044 0.0111
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.081 0.2227 0.2225
Schistosoma mansoni opsin-like receptor 0.0055 0.0114 0.0111
Echinococcus granulosus growth factor receptor bound protein 2 0.0017 0.0007 0.002
Schistosoma mansoni patched 1 0.0086 0.02 0.0197
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0023 0.0024 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0028 0.008
Echinococcus multilocularis cyclins 0.0039 0.0067 0.0098
Echinococcus multilocularis integrin beta 2 0.0495 0.1344 0.1974
Schistosoma mansoni neuropeptide receptor 0.0055 0.0114 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.0885 0.273
Echinococcus granulosus tyrosine protein kinase Blk 0.0069 0.0152 0.0426
Onchocerca volvulus 0.0055 0.0114 0.0423
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0911 0.2508 0.7019
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0114 0.0319
Echinococcus granulosus DNA excision repair protein ERCC 1 0.0016 0.0003 0.0008
Echinococcus granulosus tar DNA binding protein 0.0063 0.0135 0.0379
Brugia malayi beta-lactamase family protein 0.0074 0.0166 0.0453
Onchocerca volvulus 0.081 0.2227 0.8878
Echinococcus granulosus c src tyrosine kinase 0.0021 0.0016 0.0046
Brugia malayi Calcitonin receptor-like protein seb-1 0.0996 0.2747 0.7685
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0012 0.0018
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Onchocerca volvulus 0.0094 0.0222 0.0856
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.0105 0.0254 0.0711
Trichomonas vaginalis cyclins, putative 0.0093 0.0218 0.0642
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0037 0.0063 0.006
Onchocerca volvulus 0.0055 0.0114 0.0423
Echinococcus granulosus nibrin 0.002 0.0015 0.0042
Onchocerca volvulus 0.0074 0.0166 0.0633
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Schistosoma mansoni nAChR subunit 0.0154 0.0389 0.0387
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0079 0.018 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0176
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.006 0.0177
Onchocerca volvulus 0.002 0.0015 0.0027
Schistosoma mansoni hypothetical protein 0.0706 0.1936 0.1934
Echinococcus granulosus snurportin 1 0.0675 0.1847 0.517
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0022 0.0019 0.0019
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0114 0.0423
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0314 0.0837 0.1229
Loa Loa (eye worm) TK protein kinase 0.0062 0.0131 0.0367
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0135 0.0132
Onchocerca volvulus 0.0268 0.0709 0.2805
Echinococcus multilocularis serotonin receptor 0.0055 0.0114 0.0167
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0068 0.0148 0.0218
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0314 0.0837 0.2333
Brugia malayi Melatonin receptor type 1A 0.0055 0.0114 0.0306
Entamoeba histolytica cyclin, putative 0.0093 0.0218 0.2255
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.006 0.0159
Schistosoma mansoni nAChR subunit 0.0314 0.0837 0.0834
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0314 0.0837 0.2333
Brugia malayi Pre-SET motif family protein 0.0236 0.0618 0.172
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Echinococcus multilocularis tumor protein p63 0.0331 0.0886 0.1301
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0028 0.008
Schistosoma mansoni hypothetical protein 0.0055 0.0114 0.0111
Echinococcus granulosus cyclins 0.0039 0.0067 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0053 0.0051
Brugia malayi Integrin beta pat-3 precursor 0.0574 0.1564 0.4372
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0176
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.116 0.3206 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0996 0.2747 0.7688
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0003
Trichomonas vaginalis cyclins, putative 0.0093 0.0218 0.0642
Trichomonas vaginalis cyclin B3, putative 0.0039 0.0067 0.0169
Echinococcus multilocularis geminin 0.0706 0.1936 0.2843
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.02 0.0559
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0166 0.0453
Echinococcus multilocularis protein patched 0.0086 0.02 0.0293
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0028 0.008
Loa Loa (eye worm) inositol-1 0.0036 0.006 0.0167
Echinococcus granulosus orexin receptor type 2 0.0055 0.0114 0.0319
Echinococcus granulosus glycine receptor subunit alpha 1 0.0314 0.0837 0.2343
Echinococcus granulosus cyclin B3 1 0.0039 0.0067 0.0187
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0039 0.0108
Loa Loa (eye worm) RGC/RGC protein kinase 0.003 0.0042 0.0118
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0068 0.0148 0.038
Brugia malayi follicle stimulating hormone receptor 0.0292 0.0776 0.2163
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0068 0.0148 0.038
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Trichomonas vaginalis cyclin B, putative 0.0093 0.0218 0.0642
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.004 0.0037
Echinococcus granulosus expressed protein 0.0384 0.1034 0.2895
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0112
Plasmodium falciparum cysteine repeat modular protein 1 0.0045 0.0085 0.0209
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0314 0.0837 0.1229
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0114 0.0319
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0044 0.0083 0.0122
Brugia malayi Uncoordinated protein 44 0.0029 0.004 0.0099
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0063 0.0176
Treponema pallidum fructose-bisphosphate aldolase 0.0331 0.0885 0.247
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0029 0.0039 0.0108
Loa Loa (eye worm) hypothetical protein 0.0063 0.0136 0.038
Echinococcus granulosus tyrosine kinase 0.0069 0.0152 0.0426
Brugia malayi Dopamine receptor protein 2 0.0055 0.0114 0.0306
Schistosoma mansoni topbp1 0.002 0.0015 0.0012
Toxoplasma gondii hypothetical protein 0.0029 0.0041 0.0106
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0156 0.0438
Brugia malayi regulator of G-protein signaling egl-10 0.0029 0.0039 0.0095
Schistosoma mansoni hypothetical protein 0.0105 0.0252 0.0249
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0162 0.0411 0.1275
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0014 0.0011
Echinococcus granulosus axis inhibition protein axin 0.002 0.0014 0.0039
Echinococcus granulosus fibrillin 1 0.0022 0.0019 0.0053
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0012 0.0017
Echinococcus granulosus expressed conserved protein 0.0188 0.0486 0.1361
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0042
Mycobacterium tuberculosis Conserved protein 0.0074 0.0166 0.051
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0135 0.0199
Schistosoma mansoni hypothetical protein 0.0417 0.1127 0.1124
Echinococcus multilocularis cyclin b3 0.0039 0.0067 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0012 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0114 0.0167
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0014 0.0039
Schistosoma mansoni DNA ligase IV 0.002 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Schistosoma mansoni nAChR subunit 0.0314 0.0837 0.0834
Onchocerca volvulus 0.0025 0.0028 0.0082
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.1284 0.4001
Toxoplasma gondii hypothetical protein 0.0037 0.0063 0.0168
Loa Loa (eye worm) hypothetical protein 0.0074 0.0166 0.0465
Onchocerca volvulus 0.0074 0.0166 0.0633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0349 0.0347
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0015 0.0006
Schistosoma mansoni topbp1 0.002 0.0015 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0166 0.0436
Brugia malayi neuropeptide F receptor 0.0055 0.0114 0.0306
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0028 0.0171
Brugia malayi ecdysteroid receptor 0.0019 0.0012 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0053 0.0078
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0014 0.0039
Echinococcus granulosus Ankyrin 0.0029 0.004 0.0112
Onchocerca volvulus 0.0037 0.0063 0.0219
Echinococcus granulosus replication factor c subunit 1 0.002 0.0015 0.0042
Toxoplasma gondii exonuclease III APE 0.0019 0.0013 0.0028
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0017 0.0007 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0028 0.008
Brugia malayi latrophilin 2 splice variant baaae 0.0417 0.1127 0.3146
Echinococcus multilocularis nibrin 0.002 0.0015 0.0022
Brugia malayi hypothetical protein 0.0154 0.0389 0.1079
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.02 0.0559
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0012 0.0018
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0114 0.0167
Schistosoma mansoni inositol monophosphatase 0.0036 0.006 0.0057
Entamoeba histolytica protein kinase, putative 0.0062 0.0131 0.1301
Brugia malayi PXA domain containing protein 0.002 0.0014 0.0027
Echinococcus granulosus serotonin receptor 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0042
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0093 0.0218 0.0576
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0068 0.0148 0.0386
Mycobacterium ulcerans hypothetical protein 0.0344 0.0922 0.2871
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0015 0.0006
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0028 0.008
Schistosoma mansoni nAChR subunit 0.0314 0.0837 0.0834
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0114 0.0167
Echinococcus granulosus tyrosine protein kinase Fyn 0.0079 0.018 0.0503
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0049 0.0144
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.016 0.0406 0.1126
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.006 0.0146
Entamoeba histolytica hypothetical protein 0.002 0.0014 0.0012
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0114 0.0167
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0015 0.0006
Toxoplasma gondii subtilisin SUB12 0.0037 0.0063 0.0168
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Brugia malayi Kringle domain containing protein 0.0045 0.0085 0.0226
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0014 0.0021
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0162 0.0411 0.1275
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Loa Loa (eye worm) hypothetical protein 0.0086 0.02 0.0559
Echinococcus granulosus NCK adaptor protein 0.0017 0.0007 0.002
Echinococcus multilocularis disks large 3 0.0024 0.0025 0.0037
Leishmania major importin beta-1 subunit, putative 0.0051 0.0102 0.0251
Brugia malayi Latrophilin receptor protein 2 0.0193 0.0499 0.1387
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0349 0.0513
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0156 0.0438
Onchocerca volvulus 0.0093 0.0218 0.084
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0012 0.001
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0114 0.0167
Schistosoma mansoni nAChR subunit 0.0314 0.0837 0.0834
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0068 0.0148 0.0454
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.001
Plasmodium vivax importin-beta 2, putative 0.0063 0.0136 0.035
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0015 0.0011
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.004 0.0112
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0011 0.0025
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0047 0.0089 0.0131
Chlamydia trachomatis DNA ligase 0.0036 0.0059 0.0157
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0063 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0015 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0034
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0014 0.0039
Toxoplasma gondii PAN domain-containing protein 0.0578 0.1576 0.4406
Brugia malayi hypothetical protein 0.0102 0.0243 0.0668
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0114 0.0167
Loa Loa (eye worm) hypothetical protein 0.0178 0.0458 0.1281
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0021 0.0016 0.0046
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0013 0.0032
Onchocerca volvulus 0.0055 0.0114 0.0423
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0028 0.0171
Echinococcus multilocularis sex peptide receptor 0.0055 0.0114 0.0167
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0911 0.2508 0.7019
Schistosoma mansoni hypothetical protein 0.0045 0.0085 0.0082
Brugia malayi SRC-1 0.0079 0.018 0.0491
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0114 0.0167
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0015 0.0034
Loa Loa (eye worm) hypothetical protein 0.016 0.0406 0.1137
Toxoplasma gondii hypothetical protein 0.0037 0.0063 0.0168
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.006 0.0513
Echinococcus granulosus nAChR subunit 0.0314 0.0837 0.2343
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0136 0.0372
Entamoeba histolytica hypothetical protein 0.0071 0.0157 0.1583
Schistosoma mansoni hypothetical protein 0.0193 0.0499 0.0497
Schistosoma mansoni importin beta-1 0.0063 0.0136 0.0133
Schistosoma mansoni gabp alpha 0.0071 0.0156 0.0154
Schistosoma mansoni tyrosine kinase 0.0079 0.018 0.0177
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0114 0.0111
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0047 0.0089 0.0214
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0314 0.0837 0.2343
Loa Loa (eye worm) acetylcholine receptor protein 0.0154 0.0389 0.109
Brugia malayi hypothetical protein 0.0071 0.0157 0.0427
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0012 0.001
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0005 0.0013
Leishmania major hypothetical protein, conserved 0.0045 0.0085 0.0203
Schistosoma mansoni nck2/grb4 0.0017 0.0007 0.0004
Brugia malayi Importin beta-1 subunit 0.0063 0.0136 0.0367
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0314 0.0837 0.1229
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0166 0.0431
Mycobacterium leprae Probable lipase LipE 0.0074 0.0166 0.051
Brugia malayi excitatory GABA receptor EXP-1A 0.0314 0.0837 0.2333
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0015 0.0006
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0114 0.0306
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0314 0.0837 0.2343
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.003
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0083 0.0191 0.0507
Loa Loa (eye worm) integrin beta-2 0.0574 0.1564 0.4379
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Schistosoma mansoni hypothetical protein 0.0193 0.0499 0.0497
Echinococcus granulosus receptor type guanylyl cyclase 0.003 0.0042 0.0118
Giardia lamblia High cysteine protein 0.0022 0.0019 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0028 0.0067
Echinococcus granulosus sex peptide receptor 0.0055 0.0114 0.0319
Echinococcus granulosus tyrosine protein kinase Fyn 0.0079 0.018 0.0503
Echinococcus multilocularis tissue type plasminogen activator 0.0045 0.0085 0.0125
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0114 0.0111
Mycobacterium leprae conserved hypothetical protein 0.0344 0.0922 0.2871
Schistosoma mansoni hypothetical protein 0.0029 0.004 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0015 0.0006
Echinococcus multilocularis tyrosine protein kinase Abl 0.0021 0.0016 0.0024
Echinococcus multilocularis glycine receptor subunit beta 0.0314 0.0837 0.1229
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0114 0.0111
Entamoeba histolytica hypothetical protein 0.0026 0.0033 0.0219
Brugia malayi Ets-domain containing protein 0.0071 0.0156 0.0426
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.003
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0014 0.0021
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.006 0.0088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0114 0.0111
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0047 0.0089 0.0219
Onchocerca volvulus 0.0037 0.0063 0.0219
Brugia malayi hypothetical protein 0.002 0.0014 0.0027
Brugia malayi Cation transporter family protein 0.081 0.2227 0.623
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0014 0.0011
Echinococcus multilocularis tyrosine protein kinase Blk 0.0069 0.0152 0.0224
Echinococcus multilocularis fibrillin 2 0.0022 0.0019 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0003
Echinococcus granulosus GTP binding nuclear protein Ran 0.0047 0.0089 0.0249
Mycobacterium ulcerans hypothetical protein 0.0074 0.0166 0.051
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0015 0.0006
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0014 0.0039
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0013 0.0036
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0037 0.0063 0.0168
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.016 0.0406 0.1126
Brugia malayi RE15519p 0.0055 0.0114 0.0306
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0012 0.0018
Brugia malayi hypothetical protein 0.0154 0.0389 0.1079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0012 0.0018
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0114 0.0167
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0014 0.0027
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Schistosoma mansoni hypothetical protein 0.0193 0.0499 0.0497
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0156 0.023
Loa Loa (eye worm) beta-lactamase 0.0074 0.0166 0.0465
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0285 0.0797
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0314 0.0837 0.0834
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0114 0.0111
Echinococcus granulosus allatostatin A receptor 0.0055 0.0114 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0012 0.0022
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0283 0.075 0.1101
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0114 0.0167
Schistosoma mansoni amine GPCR 0.0055 0.0114 0.0111
Leishmania major GTP-binding protein, putative 0.0047 0.0089 0.0214
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0012 0.0022
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0154 0.0389 0.1079
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0015 0.0029
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0014 0.0039
Echinococcus multilocularis growth factor receptor bound protein 2 0.0017 0.0007 0.0011
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.0885 0.273
Echinococcus multilocularis DNA excision repair protein ERCC 1 0.0016 0.0003 0.0004
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.0529 0.0526
Brugia malayi CHE-14 protein 0.0086 0.02 0.0547
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0083 0.0191 0.0528
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0033 0.0094
Trypanosoma brucei RNA helicase, putative 0.0105 0.0252 0.0671
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0114 0.0111
Mycobacterium tuberculosis Conserved protein 0.0074 0.0166 0.051
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0176
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0102 0.0243 0.068
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0042
Echinococcus granulosus intermediate filament protein 0.0031 0.0044 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0034
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0015 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0114 0.0111
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.006 0.0131
Echinococcus granulosus dna repair protein rad51 1 0.0023 0.0024 0.0066
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0079 0.018 0.0264
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0023 0.0024 0.003
Brugia malayi EGF-like domain containing protein 0.0022 0.0019 0.0041
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0063 0.0168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0166 0.0163
Echinococcus granulosus atrial natriuretic peptide receptor 0.0024 0.0026 0.0072
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0102 0.0251
Brugia malayi ORL1-like opioid receptor 0.0055 0.0114 0.0306
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0314 0.0837 0.2343
Giardia lamblia Tenascin precursor 0.0022 0.0019 0.0184
Loa Loa (eye worm) hypothetical protein 0.0094 0.0222 0.0622
Brugia malayi protein-tyrosine kinase 0.0069 0.0152 0.0414
Echinococcus granulosus microtubule associated protein 2 0.0781 0.2145 0.6004
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0166 0.048
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0014 0.0011
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.1291 0.3572 1
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Brugia malayi Kelch motif family protein 0.0102 0.0243 0.0668
Giardia lamblia Cyclin A 0.0039 0.0067 0.0726
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0114 0.0319
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0013 0.0019
Entamoeba histolytica hypothetical protein, conserved 0.0344 0.0922 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0154 0.0389 0.1079
Entamoeba histolytica hypothetical protein 0.016 0.0406 0.4324
Echinococcus granulosus cyclin B 0.0093 0.0218 0.061
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0047 0.0089 0.0237
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0114 0.0319
Brugia malayi hypothetical protein 0.002 0.0014 0.0027
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0314 0.0837 0.0834
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0154 0.0389 0.0572
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0079 0.018 0.0264
Onchocerca volvulus Netrin receptor homolog 0.0029 0.004 0.0128
Echinococcus multilocularis lamin dm0 0.0031 0.0044 0.0065
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0023 0.0023 0.0034
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0157 0.023
Echinococcus multilocularis protein jagged 2 0.0022 0.0019 0.0028
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0114 0.0167
Schistosoma mansoni amine GPCR 0.0055 0.0114 0.0111
Schistosoma mansoni neuropeptide receptor 0.0055 0.0114 0.0111
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0417 0.1126 0.3507
Echinococcus multilocularis glycine receptor subunit beta 0.0314 0.0837 0.1229
Loa Loa (eye worm) SRC-1 0.0079 0.018 0.0503
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0012 0.0034
Echinococcus granulosus netrin receptor unc 5 0.0029 0.004 0.0112
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0028 0.008
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0015 0.0006
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0063 0.0176
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0014 0.0011
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0114 0.0319
Schistosoma mansoni z-protein (S1r protein) 0.0029 0.0039 0.0036
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0131 0.0326 0.1008
Plasmodium falciparum cyclin 0.0039 0.0067 0.0157
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.006 0.0131
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0114 0.0319
Brugia malayi TAR-binding protein 0.0063 0.0135 0.0366
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0014 0.0039
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0162 0.0411 0.1275
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0114 0.0319
Trichomonas vaginalis cyclin B, putative 0.0093 0.0218 0.0642
Entamoeba histolytica hypothetical protein 0.002 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Echinococcus granulosus Niemann Pick C1 protein 0.0287 0.0761 0.2131
Toxoplasma gondii PAN/Apple domain-containing protein 0.0037 0.0063 0.0168
Echinococcus granulosus tissue type plasminogen activator 0.0045 0.0085 0.0238
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0114 0.0319
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0114 0.0167
Loa Loa (eye worm) hypothetical protein 0.016 0.0406 0.1137
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0083 0.0191 0.0559
Trichomonas vaginalis cyclins, putative 0.0063 0.0136 0.0386
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0083 0.0191 0.0528
Schistosoma mansoni tyrosine kinase 0.0021 0.0016 0.0014
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0154 0.0389 0.0572
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0314 0.0837 0.2333
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0222 0.061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.0885 0.273
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0114 0.0319
Schistosoma mansoni neurotransmitter gated ion channel 0.0154 0.0389 0.0387
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0114 0.0319
Brugia malayi AKH receptor 0.0055 0.0114 0.0306
Schistosoma mansoni axis inhibition protein axin 0.002 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.0074 0.0166 0.0465
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.008
Entamoeba histolytica acetyltransferase, GNAT family 0.0076 0.0172 0.1749
Echinococcus granulosus axis inhibition protein axin 0.002 0.0014 0.0039
Trichomonas vaginalis cyclin D, putative 0.0039 0.0067 0.0169
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0039
Trichomonas vaginalis bromodomain-containing protein, putative 0.0083 0.0191 0.0559
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0045 0.0085 0.0209
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0068 0.0148 0.0454
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0033 0.0062
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0114 0.0111
Brugia malayi EGF-like domain containing protein 0.0022 0.0019 0.0041
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0014 0.0011
Echinococcus multilocularis expressed protein 0.0384 0.1034 0.1519
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0114 0.0319
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0023 0.0023 0.0034
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0675 0.1847 0.517
Schistosoma mansoni intermediate filament proteins 0.0031 0.0044 0.0041
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0114 0.0167
Brugia malayi G protein-coupled receptor 0.0055 0.0114 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0003
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0911 0.2508 0.7019
Schistosoma mansoni tyrosine kinase 0.0079 0.018 0.0177
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0114 0.0319
Onchocerca volvulus 0.0037 0.0063 0.0219
Trichomonas vaginalis cyclin A, putative 0.0093 0.0218 0.0642
Echinococcus granulosus glycine receptor subunit beta 0.0314 0.0837 0.2343
Mycobacterium ulcerans hypothetical protein 0.0344 0.0922 0.2871
Echinococcus granulosus integrin beta 2 0.0495 0.1344 0.3762
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0044 0.0083 0.0232
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0114 0.0167
Echinococcus multilocularis nAChR subunit 0.016 0.0406 0.0597
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.004 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0135 0.0132
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0314 0.0837 0.1229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0012 0.0034
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.02 0.0293
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.003
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0033 0.0056
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0222 0.0219
Trichomonas vaginalis cyclins, putative 0.0093 0.0218 0.0642
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0349 0.0513
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.1291 0.3572 0.5246
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0314 0.0837 0.2333
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0033 0.0094
Echinococcus granulosus g protein coupled receptor 0.0055 0.0114 0.0319
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0114 0.0167
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0114 0.0111
Echinococcus granulosus tyrosine protein kinase Fyn 0.0079 0.018 0.0503
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0079 0.018 0.0264
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0012 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0135 0.0366
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0044 0.0083 0.0232
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0039
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Echinococcus granulosus tm gpcr rhodopsin 0.106 0.2926 0.8192
Schistosoma mansoni ran 0.0047 0.0089 0.0086
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Echinococcus granulosus fibrillin 2 0.0022 0.0019 0.0053
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0017 0.0007 0.002
Schistosoma mansoni integrin beta subunit 0.0393 0.106 0.1057
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0013 0.0032
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0166 0.051
Schistosoma mansoni nAChR subunit 0.0314 0.0837 0.0834
Entamoeba histolytica hypothetical protein 0.002 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0176
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0154 0.0389 0.109
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0079 0.018 0.0264
Loa Loa (eye worm) hypothetical protein 0.0193 0.0499 0.1398
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.004 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0114 0.0111
Echinococcus multilocularis fibrillin 1 0.0022 0.0019 0.0028
Echinococcus granulosus geminin 0.0706 0.1936 0.5419
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0003
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0114 0.0319
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.006 0.0131
Brugia malayi Serotonin receptor 0.0055 0.0114 0.0306
Echinococcus granulosus lamin dm0 0.0031 0.0044 0.0124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0352 0.0943 0.1385
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0007 0.0008
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.1291 0.3572 1
Onchocerca volvulus 0.016 0.0406 0.1593
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.0885 0.273
Loa Loa (eye worm) ACC-1 protein 0.0314 0.0837 0.2343
Brugia malayi sulfakinin receptor protein 0.0055 0.0114 0.0306
Giardia lamblia Replication factor C, subunit 1 0.002 0.0015 0.0138
Schistosoma mansoni regulator of G protein signaling 0.0029 0.0039 0.0036
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.116 0.3206 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.006 0.0177
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0053 0.0142
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0114 0.0423
Schistosoma mansoni hypothetical protein 0.0055 0.0114 0.0111
Entamoeba histolytica hypothetical protein 0.0071 0.0157 0.1583
Brugia malayi hypothetical protein 0.0154 0.0389 0.1079
Mycobacterium ulcerans beta-lactamase 0.0074 0.0166 0.051
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0283 0.075 0.0747
Schistosoma mansoni myosin xvIII 0.0055 0.0114 0.0111
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0114 0.0167
Mycobacterium ulcerans hypothetical protein 0.0025 0.0028 0.008
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0114 0.0111
Echinococcus multilocularis cyclins 0.0039 0.0067 0.0098
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Loa Loa (eye worm) hypothetical protein 0.081 0.2227 0.6234
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0135 0.0379
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0068 0.0148 0.038
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0068 0.0148 0.038
Schistosoma mansoni hypothetical protein 0.0055 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.016 0.0406 0.1137
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0012 0.0022
Echinococcus multilocularis cyclin B3 1 0.0039 0.0067 0.0098
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0112
Onchocerca volvulus 0.0055 0.0114 0.0423
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.004 0.0037
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0033 0.0084
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Brugia malayi Serotonin receptor 0.0055 0.0114 0.0306
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0023 0.0023 0.0063
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.006 0.0146
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0079 0.018 0.0264
Schistosoma mansoni serine-type protease inhibitor 0.3587 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0085 0.0203
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0028 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0114 0.0111
Brugia malayi beta-lactamase 0.0074 0.0166 0.0453
Giardia lamblia Neurogenic locus Notch protein precursor 0.0022 0.0019 0.0184
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0136 0.0345
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0033 0.0094
Schistosoma mansoni neuropeptide receptor 0.0055 0.0114 0.0111
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0154 0.0389 0.109
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0314 0.0837 0.2343
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0034
Echinococcus granulosus tachykinin peptides receptor 99D 0.0352 0.0943 0.264
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Brugia malayi Cation transporter family protein 0.0314 0.0837 0.2333
Echinococcus multilocularis Niemann Pick C1 protein 0.0287 0.0761 0.1118
Echinococcus granulosus tyrosine protein kinase Src64B 0.0079 0.018 0.0503
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0013 0.0028
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0017 0.0007 0.002
Loa Loa (eye worm) hypothetical protein 0.006 0.0128 0.0358
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0114 0.0319
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0135 0.0132
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Echinococcus multilocularis cyclins 0.0039 0.0067 0.0098
Trypanosoma cruzi cyclin 6, putative 0.0093 0.0218 0.0576
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0012 0.0034
Schistosoma mansoni nAChR subunit 0.0154 0.0389 0.0387
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0028 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0349 0.0347
Brugia malayi hypothetical protein 0.0154 0.0389 0.1079
Brugia malayi Protein kinase domain containing protein 0.0029 0.004 0.0099
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0166 0.051
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0068 0.0148 0.0408
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0193 0.0499 0.0733
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0012 0.0022
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.1291 0.3572 1
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0136 0.0199
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0089 0.0214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.003
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0015 0.0022
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0114 0.0167
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0053 0.0051
Echinococcus granulosus glycine receptor subunit alpha 1 0.0314 0.0837 0.2343
Echinococcus multilocularis tyrosine protein kinase HCK 0.0062 0.0131 0.0193
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0028 0.0044
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0003
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0154 0.0389 0.109
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0314 0.0837 0.2333
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.052 0.1446
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0014 0.0039
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0314 0.0837 0.2343
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0044 0.0124
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0114 0.0167
Brugia malayi GnHR receptor homolog 0.0611 0.1669 0.4665
Loa Loa (eye worm) ACC-1 protein 0.0314 0.0837 0.2343
Schistosoma mansoni neuropeptide receptor 0.0055 0.0114 0.0111
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0012 0.0034
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0068 0.0148 0.0386
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.016 0.0406 0.1126
Echinococcus granulosus tyrosine protein kinase Src42A 0.0066 0.0143 0.0401
Brugia malayi RNA binding protein 0.0063 0.0135 0.0366
Schistosoma mansoni acetylcholine receptor subunit beta 0.0154 0.0389 0.0387
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0012 0.0034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0012 0.001
Onchocerca volvulus 0.0037 0.0063 0.0219
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0911 0.2508 0.3683
Brugia malayi Protein kinase domain containing protein 0.0048 0.0094 0.0251
Schistosoma mansoni cell polarity protein 0.0024 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0656 0.1796 0.5029
Schistosoma mansoni lamin 0.0031 0.0044 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0114 0.0167
Trypanosoma cruzi DNA repair protein RAD51, putative 0.0023 0.0024 0.003
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0114 0.0319
Schistosoma mansoni protein kinase 0.003 0.0042 0.0039
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0049 0.0144
Leishmania major cyclin 0.0093 0.0218 0.0576
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0015 0.0034
Schistosoma mansoni hypothetical protein 0.0083 0.0191 0.0188
Brugia malayi steroid hormone receptor 0.0019 0.0012 0.0022
Brugia malayi Dopamine receptor protein 1 0.0055 0.0114 0.0306
Echinococcus granulosus glycine receptor subunit beta 0.0314 0.0837 0.2343
Toxoplasma gondii hypothetical protein 0.0022 0.0019 0.0046
Echinococcus multilocularis c src tyrosine kinase 0.0021 0.0016 0.0024
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0114 0.0306
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.061 0.1668 0.4661
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0047 0.0089 0.0241
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0114 0.0319
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.0006
Schistosoma mansoni regulator of G protein signaling 0.002 0.0014 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0028 0.008
Brugia malayi N-terminal motif family protein 0.0178 0.0458 0.127
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Schistosoma mansoni ets-related 0.0214 0.0559 0.0556
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0114 0.0319
Schistosoma mansoni hypothetical protein 0.0055 0.0114 0.0111
Echinococcus multilocularis GPCR, family 2 0.0193 0.0499 0.0733
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0114 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0015 0.0006
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0114 0.0111
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0012 0.001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0047 0.0089 0.0219
Echinococcus granulosus cyclins 0.0039 0.0067 0.0187
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0014 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0012 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0012 0.0022
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.116 0.3206 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0079 0.018 0.0264
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0166 0.051
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.1291 0.3572 1
Schistosoma mansoni cell polarity protein 0.0016 0.0004 0.0002
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.1291 0.3572 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0012 0.0034
Echinococcus granulosus Protein patched homolog 1 0.0086 0.02 0.0559
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.1291 0.3572 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0039 0.0067 0.0175
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0068 0.0148 0.038
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0114 0.0306
Brugia malayi Fli-1 protein 0.0214 0.0559 0.1553
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0034
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0012 0.001
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0015 0.0038
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0166 0.051
Schistosoma mansoni biogenic amine receptor 0.0055 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.016 0.0406 0.1137
Brugia malayi Inositol-1 0.0036 0.006 0.0154
Trichomonas vaginalis cyclin D, putative 0.0039 0.0067 0.0169
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0114 0.0319
Plasmodium falciparum importin beta, putative 0.0063 0.0136 0.035
Echinococcus granulosus cyclins 0.0039 0.0067 0.0187
Toxoplasma gondii microneme protein MIC17A 0.0037 0.0063 0.0168
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0314 0.0837 0.2333
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0053
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Trichomonas vaginalis ran, putative 0.0047 0.0089 0.0238
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.016 0.0406 0.1126
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0028 0.0067
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0114 0.0319
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0114 0.0306
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0193 0.0499 0.1398
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0033 0.0084
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0114 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0014 0.0003
Trichomonas vaginalis cyclin B, putative 0.0039 0.0067 0.0169
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0314 0.0837 0.1229
Plasmodium falciparum histone acetyltransferase GCN5 0.0076 0.0172 0.0452
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0012 0.0017
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0114 0.0319
Onchocerca volvulus 0.016 0.0406 0.1593
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.004 0.0112
Schistosoma mansoni netrin receptor unc5 0.0029 0.004 0.0037
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Brugia malayi DNA repair protein RAD51 homolog 1 0.0023 0.0024 0.0054
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0157 0.0439
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.016 0.0406 0.0404
Trichomonas vaginalis cyclin B, putative 0.0093 0.0218 0.0642
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0314 0.0837 0.2333
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0314 0.0837 0.2343
Onchocerca volvulus 0.0074 0.0166 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0015 0.0006
Loa Loa (eye worm) hypothetical protein 0.0034 0.0053 0.0149
Schistosoma mansoni hypothetical protein 0.0083 0.0191 0.0188
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0114 0.0319
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0021 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.081 0.2227 0.6234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0012 0.0034
Schistosoma mansoni histamine h1 receptor 0.0055 0.0114 0.0111
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0166 0.051
Schistosoma mansoni nAChR subunit 0.0314 0.0837 0.0834
Mycobacterium ulcerans adenylylate/guanylate cyclase 0.0021 0.0019 0.005
Echinococcus multilocularis Ankyrin 0.0029 0.004 0.0059
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0114 0.0319
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0166 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0114 0.0167
Schistosoma mansoni opsin-like receptor 0.0055 0.0114 0.0111
Giardia lamblia Fructose-bisphosphate aldolase 0.0331 0.0885 1
Onchocerca volvulus 0.0034 0.0053 0.0181
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0114 0.0167
Echinococcus multilocularis serotonin receptor 0.0055 0.0114 0.0167
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.052 0.5579
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0314 0.0837 0.2333
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0012 0.0034
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0135 0.0379
Echinococcus multilocularis cyclins 0.0039 0.0067 0.0098
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0033 0.0084
Onchocerca volvulus 0.0037 0.0063 0.0219
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0349 0.0966
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.003
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0136 0.0345
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0014 0.0027
Toxoplasma gondii PAN domain-containing protein 0.0578 0.1576 0.4406
Mycobacterium tuberculosis Conserved hypothetical protein 0.0344 0.0922 0.2871
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0114 0.0111
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0154 0.0389 0.1079
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0114 0.0167
Giardia lamblia Tenascin-37 0.0022 0.0019 0.0184
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0042
Entamoeba histolytica cyclin, putative 0.0039 0.0067 0.0593
Loa Loa (eye worm) hypothetical protein 0.0048 0.0095 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0012 0.0022
Brugia malayi Sex muscle abnormal protein 5 0.0017 0.0007 0.0008
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0114 0.0319
Schistosoma mansoni neurotransmitter gated ion channel 0.0154 0.0389 0.0387
Trichomonas vaginalis cyclins, putative 0.0093 0.0218 0.0642
Giardia lamblia High cysteine protein 0.0022 0.0019 0.0184
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Onchocerca volvulus 0.0019 0.0012 0.0017
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0047 0.0089 0.0977
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.1291 0.3572 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0011 0.0023
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0024 0.0026 0.0038
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0047 0.0089 0.0249
Schistosoma mansoni hypothetical protein 0.0706 0.1936 0.1934
Echinococcus granulosus neuropeptide receptor 0.0055 0.0114 0.0319
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0114 0.0167
Onchocerca volvulus 0.0055 0.0114 0.0423
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0166 0.051
Entamoeba histolytica hypothetical protein 0.0071 0.0157 0.1583
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.006 0.0167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0114 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.02 0.0585
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.0618 0.173
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0114 0.0167
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0314 0.0837 0.2333
Mycobacterium ulcerans lipase LipD 0.0074 0.0166 0.051
Toxoplasma gondii ABC1 family protein 0.0074 0.0166 0.0458
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0166 0.051
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0102 0.028
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0135 0.0132
Echinococcus granulosus tyrosine protein kinase HCK 0.0062 0.0131 0.0367
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0028 0.008
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0114 0.0167
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0023 0.0023 0.0028
Onchocerca volvulus 0.081 0.2227 0.8878
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0222 0.0622
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0014 0.0021
Echinococcus multilocularis snurportin 1 0.0675 0.1847 0.2712
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0193 0.0499 0.1387
Onchocerca volvulus 0.0055 0.0114 0.0423
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Loa Loa (eye worm) rad51 0.0023 0.0024 0.0066
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Schistosoma mansoni opsin-like receptor 0.0055 0.0114 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0012 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0028 0.0067
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0314 0.0837 0.2333
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0102 0.028
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0047 0.0089 0.0214
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.106 0.2926 0.4298
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0114 0.0319
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0166 0.0163
Onchocerca volvulus Putative nachr subunit 0.0911 0.2508 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0012 0.0034
Brugia malayi Ets-domain containing protein 0.0071 0.0156 0.0426
Schistosoma mansoni biogenic amine receptor 0.0055 0.0114 0.0111
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0018 0.0015
Brugia malayi Guanylate kinase family protein 0.0034 0.0053 0.0135
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0114 0.0167
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.016 0.0406 0.0404
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0042
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.116 0.3206 1
Plasmodium vivax SET domain protein, putative 0.0034 0.0053 0.0119
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0292 0.0776 0.2173
Echinococcus granulosus glycine receptor subunit alpha 1 0.0314 0.0837 0.2343
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0114 0.0167
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0166 0.048
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Brugia malayi Cation transporter family protein 0.0314 0.0837 0.2333
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0114 0.0319
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0114 0.0319
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0012 0.0022
Toxoplasma gondii microneme protein MIC17B 0.0037 0.0063 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0349 0.0347
Schistosoma mansoni axis inhibition protein axin 0.002 0.0014 0.0011
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0068 0.0148 0.0146
Loa Loa (eye worm) hypothetical protein 0.016 0.0406 0.1137
Brugia malayi Peripheral plasma membrane protein CASK 0.0018 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0114 0.0167
Loa Loa (eye worm) acetyltransferase 0.0283 0.075 0.2098
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0012 0.0018
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0014 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0012 0.0022
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0033 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0053 0.0051
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0028 0.008
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0114 0.0167
Onchocerca volvulus 0.0045 0.0085 0.0308
Echinococcus granulosus disks large 3 0.0024 0.0025 0.0071
Schistosoma mansoni growth factor receptor-bound protein 0.0017 0.0007 0.0004
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0028 0.0171
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.0885 0.273
Schistosoma mansoni regulator of G protein signaling 0.002 0.0014 0.0011
Loa Loa (eye worm) hypothetical protein 0.016 0.0406 0.1137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0114 0.0111
Schistosoma mansoni lamin 0.0031 0.0044 0.0041
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0068 0.0148 0.0415
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0012 0.0022
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0068 0.0148 0.038
Chlamydia trachomatis transcriptional repressor NrdR 0.0131 0.0326 0.0904
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0166 0.0431
Schistosoma mansoni amine GPCR 0.0055 0.0114 0.0111
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0034
Onchocerca volvulus 0.0037 0.0063 0.0219
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0166 0.048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0102 0.028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0114 0.0111
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0033 0.0094
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Loa Loa (eye worm) guanylate kinase 0.0027 0.0035 0.0097
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0068 0.0148 0.038
Mycobacterium leprae conserved hypothetical protein 0.0131 0.0326 0.1008
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0222 0.0326
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Schistosoma mansoni DNA repair protein RAD51 0.0023 0.0024 0.0021
Loa Loa (eye worm) cyclin domain-containing protein 0.0039 0.0067 0.0187
Echinococcus multilocularis musashi 0.0031 0.0044 0.0065
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0015 0.0006
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0063 0.0168
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Onchocerca volvulus 0.0037 0.0063 0.0219
Schistosoma mansoni hypothetical protein 0.0675 0.1847 0.1845
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.0458 0.1798
Onchocerca volvulus 0.081 0.2227 0.8878
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.005 0.014
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0314 0.0837 0.1229
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0166 0.051
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Entamoeba histolytica hypothetical protein 0.0071 0.0157 0.1583
Onchocerca volvulus 0.0154 0.0389 0.1526
Toxoplasma gondii microneme protein MIC17C 0.0037 0.0063 0.0168
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0012 0.001
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0015 0.0029
Echinococcus granulosus g protein coupled receptor 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0093 0.0218 0.061
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0039
Onchocerca volvulus 0.0055 0.0114 0.0423
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0079 0.018 0.0503
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0114 0.0167
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0053 0.0078
Onchocerca volvulus 0.0154 0.0389 0.1526
Brugia malayi nuclear receptor NHR-88 0.0019 0.0012 0.0022
Trichomonas vaginalis meiosis-specific recA homolog Dmc1 0.0023 0.0024 0.0034
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.052 0.0764
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0114 0.0167
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0314 0.0837 0.2333
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0114 0.0167
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0114 0.0306
Echinococcus multilocularis somatostatin receptor 0.0055 0.0114 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0012 0.0034
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0157 0.0154
Onchocerca volvulus 0.0031 0.0044 0.0144
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0039 0.0067 0.0098
Schistosoma mansoni regulator of G protein signaling 0.002 0.0014 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0012 0.0034
Loa Loa (eye worm) hypothetical protein 0.0054 0.011 0.0308
Schistosoma mansoni hypothetical protein 0.0083 0.0191 0.0188
Brugia malayi ribonucleotide reductase 2 0.0068 0.0148 0.0403
Brugia malayi Cyclin, N-terminal domain containing protein 0.0093 0.0218 0.0598
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0015 0.0011
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0015 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0193 0.0499 0.1398
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0114 0.0319
Entamoeba histolytica cyclin family protein 0.0039 0.0067 0.0593
Brugia malayi EGF-like domain containing protein 0.0022 0.0019 0.0041
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Brugia malayi PAN domain containing protein 0.0037 0.0063 0.0163
Onchocerca volvulus 0.0022 0.0019 0.0044
Entamoeba histolytica hypothetical protein 0.002 0.0015 0.0022
Echinococcus multilocularis netrin receptor unc 5 0.0029 0.004 0.0059
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0314 0.0837 0.2333
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0154 0.0389 0.1079
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0066 0.0143 0.021
Loa Loa (eye worm) hypothetical protein 0.0417 0.1127 0.3154
Brugia malayi Death domain containing protein 0.0029 0.004 0.0099
Schistosoma mansoni hypothetical protein 0.0083 0.0191 0.0188
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Loa Loa (eye worm) hypothetical protein 0.061 0.1668 0.4668
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0028 0.0044
Schistosoma mansoni adapter molecule crk 0.0017 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0108
Treponema pallidum DNA ligase (lig) 0.002 0.0015 0.0034
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0166 0.051
Onchocerca volvulus 0.0055 0.0114 0.0423
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0033 0.0084
Trichomonas vaginalis set domain proteins, putative 0.0268 0.0709 0.2181
Entamoeba histolytica cyclin family protein 0.0039 0.0067 0.0593
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Toxoplasma gondii meiotic recombination protein DMC1 family protein 0.0023 0.0024 0.0058
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0911 0.2508 0.3683
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0011 0.0025
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0114 0.0167
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0176
Onchocerca volvulus 0.0037 0.0063 0.0219
Onchocerca volvulus 0.0314 0.0837 0.3316
Echinococcus granulosus tumor protein p63 0.0331 0.0886 0.248
Schistosoma mansoni neurotransmitter gated ion channel 0.016 0.0406 0.0404
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0911 0.2508 0.7016
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0349 0.0978
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0012 0.0034
Echinococcus granulosus importin subunit beta 1 0.0063 0.0136 0.038
Giardia lamblia Tenascin-like 0.0022 0.0019 0.0184
Echinococcus granulosus nAChR subunit 0.016 0.0406 0.1137
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0063 0.0176
Trichomonas vaginalis esterase, putative 0.0074 0.0166 0.048
Onchocerca volvulus 0.0048 0.0095 0.0346
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0154 0.0389 0.109
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0331 0.0885 0.9585
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0068 0.0148 0.038
Onchocerca volvulus 0.0055 0.0114 0.0423
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Echinococcus granulosus cyclins 0.0039 0.0067 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0012 0.0022
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0166 0.051
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Mycobacterium tuberculosis Conserved protein 0.0074 0.0166 0.051
Echinococcus multilocularis cyclin B 0.0093 0.0218 0.032
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0013 0.0024
Echinococcus granulosus hypothetical protein 0.0055 0.0114 0.0319
Echinococcus granulosus tyrosine protein kinase Lyn 0.0079 0.018 0.0503
Loa Loa (eye worm) RNA binding protein 0.0063 0.0135 0.0379
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0069 0.0152 0.0224
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0331 0.0885 0.273
Giardia lamblia Tenascin-X 0.0022 0.0019 0.0184
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0102 0.0243 0.068
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0166 0.0465
Onchocerca volvulus 0.0037 0.0063 0.0219
Brugia malayi EGF-like domain containing protein 0.0022 0.0019 0.0041
Mycobacterium ulcerans transcriptional regulator NrdR 0.0131 0.0326 0.1008
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0911 0.2508 0.7019
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0012 0.001
Echinococcus granulosus somatostatin receptor 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0314 0.0837 0.2343
Onchocerca volvulus 0.0055 0.0114 0.0423
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0154 0.0389 0.0572
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0356 0.0955 0.2646
Echinococcus granulosus adam 0.0022 0.0019 0.0053
Brugia malayi PXA domain containing protein 0.002 0.0014 0.0027
Echinococcus granulosus neuropeptide receptor 0.0055 0.0114 0.0319
Schistosoma mansoni amine GPCR 0.0055 0.0114 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0053 0.0051
Brugia malayi hypothetical protein 0.0055 0.0114 0.0306
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0314 0.0837 0.2343
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0114 0.0319
Brugia malayi Pre-SET motif family protein 0.0034 0.0053 0.0137
Onchocerca volvulus 0.0031 0.0044 0.0144
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0166 0.048
Leishmania major hypothetical protein, conserved 0.0074 0.0166 0.0431
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0285 0.0797
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0314 0.0837 0.2333
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0114 0.0319
Loa Loa (eye worm) LGC-31 protein 0.0314 0.0837 0.2343
Echinococcus granulosus regulator of G protein signaling 7 0.0029 0.0039 0.0108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0008 0.0016
Schistosoma mansoni hypothetical protein 0.0193 0.0499 0.0497
Loa Loa (eye worm) hypothetical protein 0.0037 0.0063 0.0176
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0044 0.0083 0.0122
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0012 0.001
Echinococcus multilocularis regulator of G protein signaling 7 0.0029 0.0039 0.0057
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0114 0.0111
Brugia malayi Cyclin, N-terminal domain containing protein 0.0093 0.0218 0.0598
Onchocerca volvulus 0.0055 0.0114 0.0423
Loa Loa (eye worm) hypothetical protein 0.016 0.0406 0.1137
Leishmania major RAD51/dmc1 protein 0.0023 0.0024 0.003
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0114 0.0306
Echinococcus multilocularis tyrosine protein kinase Srms 0.0069 0.0152 0.0224
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0013 0.0036
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0012 0.0034
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2447 0.6809 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0074 0.0166 0.0465
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Trypanosoma cruzi meiotic recombination protein DMC1, putative 0.0023 0.0024 0.003
Echinococcus multilocularis receptor type guanylyl cyclase 0.003 0.0042 0.0062
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Echinococcus granulosus cyclins 0.0039 0.0067 0.0187
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0114 0.0319
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0114 0.0319
Echinococcus granulosus fmrfamide receptor 0.0055 0.0114 0.0319
Loa Loa (eye worm) hypothetical protein 0.0055 0.0114 0.0319
Onchocerca volvulus 0.0037 0.0063 0.0219
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0034
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.052 0.1456
Trypanosoma cruzi cyclin, putative 0.0093 0.0218 0.0576
Echinococcus multilocularis adam 0.0022 0.0019 0.0028
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0044 0.0124
Loa Loa (eye worm) GABA receptor subunit 0.016 0.0406 0.1137
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0114 0.0306
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0314 0.0837 0.0834
Trichomonas vaginalis hypothetical protein 0.0022 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0114 0.0319

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 110 nM Binding affinity at human GnRH receptor ChEMBL. 18419112

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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