Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | estrogen receptor 2 (ER beta) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | estrogen receptor 2 (ER beta) | 495 aa | 418 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Mycobacterium leprae | Possible lipase LipU | 0.0084 | 0.0056 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0237 | 0.0369 | 0.0095 |
Loa Loa (eye worm) | ammd protein | 0.0084 | 0.0056 | 0.0056 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0277 | 0.0222 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0237 | 0.0369 | 0.0095 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0237 | 0.0369 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0084 | 0.0056 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.14 | 0.2752 | 0.2752 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0525 | 0.096 | 0.0703 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Schistosoma mansoni | acetylcholinesterase | 0.0237 | 0.0369 | 0.0315 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0237 | 0.0369 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0084 | 0.0056 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0237 | 0.0369 | 0.0369 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Loa Loa (eye worm) | aryl-acylamidase | 0.0084 | 0.0056 | 0.0056 |
Schistosoma mansoni | gliotactin | 0.0237 | 0.0369 | 0.0315 |
Echinococcus multilocularis | carboxylesterase 5A | 0.14 | 0.2752 | 0.2546 |
Leishmania major | ecotin, putative | 0.0084 | 0.0056 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4939 | 1 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0084 | 0.0056 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 0.4939 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0237 | 0.0369 | 0.0095 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Loa Loa (eye worm) | hypothetical protein | 0.14 | 0.2752 | 0.2752 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0084 | 0.0056 | 0.5 |
Echinococcus granulosus | neuropeptide s receptor | 0.0525 | 0.096 | 0.0703 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0084 | 0.0056 | 0.5 |
Brugia malayi | hypothetical protein | 0.0237 | 0.0369 | 0.1341 |
Brugia malayi | Carboxylesterase family protein | 0.14 | 0.2752 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0237 | 0.0369 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4939 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0237 | 0.0369 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0084 | 0.0056 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0277 | 0.0222 |
Echinococcus granulosus | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Echinococcus multilocularis | neuroligin | 0.0237 | 0.0369 | 0.0095 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Brugia malayi | Carboxylesterase family protein | 0.14 | 0.2752 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0237 | 0.0369 | 0.0369 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0084 | 0.0056 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0084 | 0.0056 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0237 | 0.0369 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0525 | 0.096 | 0.0703 |
Onchocerca volvulus | 0.0237 | 0.0369 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Brugia malayi | aryl-acylamidase | 0.0084 | 0.0056 | 0.0203 |
Brugia malayi | Carboxylesterase family protein | 0.0237 | 0.0369 | 0.1341 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.4939 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Echinococcus multilocularis | acetylcholinesterase | 0.14 | 0.2752 | 0.2546 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.14 | 0.2752 | 0.2711 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0237 | 0.0369 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0237 | 0.0369 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4939 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0237 | 0.0369 | 0.0095 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0084 | 0.0056 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0237 | 0.0369 | 0.0095 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.14 | 0.2752 | 0.2752 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Echinococcus granulosus | neuroligin | 0.0237 | 0.0369 | 0.0095 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0525 | 0.096 | 0.0703 |
Echinococcus granulosus | carboxylesterase 5A | 0.14 | 0.2752 | 0.2546 |
Loa Loa (eye worm) | carboxylesterase | 0.14 | 0.2752 | 0.2752 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.0369 | 0.0369 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0237 | 0.0369 | 0.0095 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 45 nM | Binding affinity to ERbeta | ChEMBL. | 17459530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.