Detailed view for Smp_141510

Basic information

TDR Targets ID: 283679
Schistosoma mansoni, family S9 non-peptidase homologue (S09 family)
Source Database / ID:  GeneDB

pI: 7.3489 | Length (AA): 1076 | MW (Da): 125913 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00135   Carboxylesterase family
PF02214   BTB/POZ domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0008076   voltage-gated potassium channel complex  
GO:0005515   protein binding  
GO:0005249   voltage-gated potassium channel activity  
GO:0051260   protein homooligomerization  
GO:0006813   potassium ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
71 759 1akn (A) 5 545 25.00 0 1 0.580035 0.73
877 988 3kvt (A) 9 111 44.00 0 1 0.597789 -0.41
877 1075 2r9r (H) 32 206 33.00 0 0.65 0.120644 1.32
878 973 1exb (E) 37 124 34.00 0.000041 0.95 0.429819 -0.29
878 987 1t1d (A) 66 162 34.00 0 0.97 0.39533 -0.55

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_172328)

Species Accession Gene Product
Schistosoma japonicum Sjp_0111710   IPR002018,Carboxylesterase, type B,domain-containing
Schistosoma japonicum Sjp_0106950   IPR002018,Carboxylesterase, type B,domain-containing
Schistosoma japonicum Sjp_0008850   Neuroligin-4, X-linked precursor, putative
Schistosoma mansoni Smp_141510   family S9 non-peptidase homologue (S09 family)
Schmidtea mediterranea mk4.000802.06  
Schmidtea mediterranea mk4.000802.05   Family S9 non-peptidase homologue
Schmidtea mediterranea mk4.006235.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Equus caballus Cholinesterase 574 aa 25.1% 590 aa Compounds References
Laodelphax striatella Acetylcholinesterase 426 aa 27.3% 362 aa Compounds References
Equus caballus Butyrylcholinesterase 602 aa 25.3% 590 aa Compounds References
Musca domestica Acetylcholinesterase 692 aa 22.0% 590 aa Compounds References
Bos taurus Cholesterol esterase 597 aa 23.7% 657 aa Compounds References
Rattus norvegicus Acetylcholinesterase 614 aa 24.3% 602 aa Compounds References
Torpedo californica Acetylcholinesterase 586 aa 24.4% 602 aa Compounds References
Rattus norvegicus Butyrylcholinesterase 597 aa 25.2% 591 aa Compounds References
Bos taurus Acetylcholinesterase 613 aa 23.6% 601 aa Compounds References
Electrophorus electricus Acetylcholinesterase 633 aa 24.9% 622 aa Compounds References
Anopheles gambiae Acetylcholinesterase 737 aa 24.2% 636 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0053 0.5 0.5
0.0021 0.5 0.5
0.0021 0.5 0.5
0.0018 0.5 0.5
0.007 0.5066 0.7296
0.0038 0.5 0.5
0.0021 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_141510 (Schistosoma mansoni), family S9 non-peptidase homologue (S09 family)
Title for this comment
Comment