Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | elastase, neutrophil expressed | Starlite/ChEMBL | References |
Bos taurus | Cholesterol esterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Cholesterol esterase | 597 aa | 607 aa | 28.2 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Cholesterol esterase | 597 aa | 536 aa | 27.1 % |
Brugia malayi | Carboxylesterase family protein | Cholesterol esterase | 597 aa | 481 aa | 24.3 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholesterol esterase | 597 aa | 570 aa | 28.4 % |
Brugia malayi | Carboxylesterase family protein | Cholesterol esterase | 597 aa | 554 aa | 28.7 % |
Echinococcus granulosus | acetylcholinesterase | Cholesterol esterase | 597 aa | 511 aa | 32.5 % |
Onchocerca volvulus | Cholesterol esterase | 597 aa | 495 aa | 27.7 % | |
Onchocerca volvulus | Cholesterol esterase | 597 aa | 555 aa | 27.4 % | |
Onchocerca volvulus | Cholesterol esterase | 597 aa | 587 aa | 25.6 % | |
Onchocerca volvulus | Putative nuclear protein | Cholesterol esterase | 597 aa | 557 aa | 30.2 % |
Brugia malayi | Carboxylesterase family protein | Cholesterol esterase | 597 aa | 545 aa | 27.5 % |
Schistosoma mansoni | gliotactin | Cholesterol esterase | 597 aa | 581 aa | 30.1 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Cholesterol esterase | 597 aa | 540 aa | 30.6 % |
Brugia malayi | Carboxylesterase family protein | Cholesterol esterase | 597 aa | 546 aa | 26.7 % |
Loa Loa (eye worm) | hypothetical protein | Cholesterol esterase | 597 aa | 550 aa | 27.5 % |
Echinococcus granulosus | transmembrane protease serine 3 | elastase, neutrophil expressed | 267 aa | 236 aa | 27.5 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Cholesterol esterase | 597 aa | 657 aa | 23.7 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Cholesterol esterase | 597 aa | 643 aa | 26.0 % |
Echinococcus multilocularis | acetylcholinesterase | Cholesterol esterase | 597 aa | 517 aa | 32.7 % |
Echinococcus granulosus | BC026374 protein S09 family | Cholesterol esterase | 597 aa | 664 aa | 25.9 % |
Loa Loa (eye worm) | acetylcholinesterase 1 | Cholesterol esterase | 597 aa | 561 aa | 31.2 % |
Echinococcus multilocularis | acetylcholinesterase | Cholesterol esterase | 597 aa | 663 aa | 28.2 % |
Loa Loa (eye worm) | hypothetical protein | Cholesterol esterase | 597 aa | 478 aa | 24.9 % |
Echinococcus granulosus | acetylcholinesterase | Cholesterol esterase | 597 aa | 645 aa | 28.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0021 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0021 | 0.5 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.5 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0021 | 0.5 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0021 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0021 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0021 | 0.5 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0021 | 0.5 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | gliotactin | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0021 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0021 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0021 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0021 | 0.5 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0021 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0021 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry | ChEMBL. | 16366609 |
IC50 (binding) | > 50 uM | Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry | ChEMBL. | 16366609 |
K (ADMET) | = 0.032 M-1 s-1 | The alkaline hydrolysis second order rate constant(K OH) of the compound | ChEMBL. | 10639285 |
Ki (binding) | = -7.9 | Inhibitory activity of the compound was tested against human leukocyte elastase | ChEMBL. | 10639285 |
Ki (binding) | = -7.79 | Negative logarithm of steady state constant Ki for enzyme-inhibitor complex Human Leukocyte Elastase inhibition | ChEMBL. | 9572899 |
Ki (binding) | = 13 nM | Inhibitory activity of the compound was tested against human leukocyte elastase | ChEMBL. | 10639285 |
Ki (binding) | = 13 nM | Inhibitory activity of the compound was tested against human leukocyte elastase | ChEMBL. | 10639285 |
Ki (binding) | = 16.3 nM | Steady state inhibition constant for Human Leukocyte Elastase inhibition | ChEMBL. | 9572899 |
Ki (binding) | = 16.3 nM | Steady state inhibition constant for Human Leukocyte Elastase inhibition | ChEMBL. | 9572899 |
Ki (binding) | = 1.86 uM | Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometry | ChEMBL. | 16366609 |
Ki (binding) | = 1.86 uM | Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometry | ChEMBL. | 16366609 |
koff (binding) | = 0.612 | First order rate constant enzyme-inhibitor complex human leukocyte Elastase was determined | ChEMBL. | 9572899 |
Koff (binding) | = 0.32 s-1 | Koff was the deacylation association equilibrium rate constant of the compound of a competitive inhibition human leukocyte elastase(HLE). | ChEMBL. | 10639285 |
kOH- (ADMET) | = 0.025 M-1 s-1 | Alakaline hydrolysis rate (k-OH) | ChEMBL. | 9572899 |
kon (binding) | = 3.75 10e3* M-1 s-1 | Second order rate constant for enzyme-inhibitor complex Human Leukocyte Elastase inhibition was determined | ChEMBL. | 9572899 |
kon (binding) | = 3.75 10e3* M-1 s-1 | Second order rate constant for enzyme-inhibitor complex Human Leukocyte Elastase inhibition was determined | ChEMBL. | 9572899 |
Kon (binding) | = 2500 M-1 s-1 | Kon was the acylation association equilibrium rate constant of the compound of a competitive inhibition of human leukocyte elastase(HLE). | ChEMBL. | 10639285 |
k_off (binding) | = 0.32 s-1 | Koff was the deacylation association equilibrium rate constant of the compound of a competitive inhibition human leukocyte elastase(HLE). | ChEMBL. | 10639285 |
k_on (binding) | = 2500 M-1 s-1 | Kon was the acylation association equilibrium rate constant of the compound of a competitive inhibition of human leukocyte elastase(HLE). | ChEMBL. | 10639285 |
Log K (binding) | = -1.49 | The alkaline hydrolysis second order rate constant(K OH) of the compound taken as log K. | ChEMBL. | 10639285 |
Log Ki (binding) | = 7.79 | Negative logarithm of steady state constant Ki for enzyme-inhibitor complex Human Leukocyte Elastase inhibition | ChEMBL. | 9572899 |
Log Ki (binding) | = 7.9 | Inhibitory activity of the compound was tested against human leukocyte elastase | ChEMBL. | 10639285 |
Log kOH- (ADMET) | = 1.59 | Alkaline hydrolysis rate (logk-OH) | ChEMBL. | 9572899 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.