Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Monoglyceride lipase | Starlite/ChEMBL | References |
Rattus norvegicus | Anandamide amidohydrolase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.7717 | 0.7708 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0445 | 0.0297 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.1895 | 0.3681 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.1895 | 0.3681 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0015 | 0.0565 | 0.0527 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1525 | 0.1745 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.1308 | 0.1174 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0508 | 0.0368 |
Leishmania major | hypothetical protein, conserved | 0.0015 | 0.0565 | 0.0255 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.515 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0013 | 0.0445 | 0.0864 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.1895 | 0.3681 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2508 | 0.2393 |
Trypanosoma cruzi | amidase, putative | 0.0015 | 0.0565 | 0.0255 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1895 | 0.3083 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1895 | 0.3083 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.1895 | 0.3083 |
Brugia malayi | putative amidase | 0.0015 | 0.0565 | 0.0426 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0565 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.1895 | 0.3681 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.142 | 0.1294 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2508 | 0.2901 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0.0565 | 0.5 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0084 | 0.515 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.142 | 0.1622 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.855 | 1 |
Echinococcus multilocularis | lamin | 0.0026 | 0.1308 | 0.1273 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0013 | 0.0445 | 0.0864 |
Brugia malayi | amidase | 0.0123 | 0.7717 | 0.7684 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.1308 | 0.1174 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2508 | 0.2901 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0123 | 0.7717 | 0.9022 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.1895 | 0.218 |
Plasmodium vivax | PST-A protein | 0.0084 | 0.515 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.1895 | 0.1863 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0565 | 0.0617 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.1895 | 0.3083 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0084 | 0.515 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.515 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0084 | 0.515 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.1525 | 0.1491 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2508 | 0.2478 |
Loa Loa (eye worm) | amidase | 0.0015 | 0.0565 | 0.0419 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0084 | 0.515 | 1 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.1308 | 0.118 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0013 | 0.0445 | 0.0864 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0015 | 0.0565 | 0.0527 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0084 | 0.515 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.1895 | 0.1776 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0416 | 0.0377 |
Echinococcus multilocularis | musashi | 0.0026 | 0.1308 | 0.1273 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.855 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.3063 | 1 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0416 | 0.0377 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0013 | 0.0445 | 0.0304 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.1308 | 0.118 |
Schistosoma mansoni | lamin | 0.0026 | 0.1308 | 0.149 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0015 | 0.0565 | 0.0527 |
Schistosoma mansoni | amidase | 0.0123 | 0.7717 | 0.9022 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Onchocerca volvulus | 0.0026 | 0.1308 | 0.1672 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1308 | 0.1174 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.7717 | 0.7708 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0084 | 0.515 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0084 | 0.515 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.1895 | 0.3083 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1525 | 0.1745 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.142 | 0.1288 |
Brugia malayi | Amidase family protein | 0.0015 | 0.0565 | 0.0426 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0152 | 0.0112 |
Mycobacterium ulcerans | hypothetical protein | 0.0084 | 0.515 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.515 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0015 | 0.0565 | 0.0255 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.515 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0508 | 0.0361 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2508 | 0.2478 |
Leishmania major | monoglyceride lipase, putative | 0.0084 | 0.515 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2508 | 0.2478 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0084 | 0.515 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.1308 | 0.1273 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0015 | 0.0565 | 0.0527 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Onchocerca volvulus | 0.0091 | 0.5608 | 1 | |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.1308 | 0.1273 |
Plasmodium falciparum | esterase, putative | 0.0084 | 0.515 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.1895 | 0.3681 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0416 | 0.0268 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.1895 | 0.3083 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0015 | 0.0565 | 0.0617 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0123 | 0.7717 | 0.7708 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.1895 | 0.177 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Onchocerca volvulus | 0.0028 | 0.142 | 0.1889 | |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.1308 | 0.1273 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2508 | 0.2478 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.515 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2508 | 0.2398 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.1308 | 0.1273 |
Plasmodium falciparum | lysophospholipase, putative | 0.0084 | 0.515 | 1 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.1895 | 0.1863 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.7717 | 0.7682 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0384 | 0.0236 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.1308 | 0.149 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0123 | 0.7717 | 0.7708 |
Loa Loa (eye worm) | amidase | 0.0015 | 0.0565 | 0.0419 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0015 | 0.0565 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1277 | 0.1142 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.3479 | 0.4041 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0084 | 0.515 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 0.1308 | 0.149 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 1 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.1525 | 0.1491 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0384 | 0.0236 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0015 | 0.0565 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0013 | 0.0445 | 0.0864 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0152 | 0.0112 |
Brugia malayi | Amidase family protein | 0.0015 | 0.0565 | 0.0426 |
Onchocerca volvulus | 0.0026 | 0.1308 | 0.1672 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2508 | 0.2901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.