pI: 8.7579 |
Length (AA): 621 |
MW (Da): 69604 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
58 | 615 | 3ppm (A) | 35 | 570 | 35.00 | 0 | 1 | 1.40015 | -1 |
60 | 618 | 3ppm (A) | 34 | 573 | 38.00 | 0 | 1 | 1.37636 | -0.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127783)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_28250 | amidase |
Candida albicans | CaO19.6557 | one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) |
Candida albicans | CaO19.13910 | one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) |
Candida albicans | CaO19.12636 | one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) |
Candida albicans | CaO19.5169 | one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) |
Candida albicans | CaO19_5169 | hypothetical protein |
Candida albicans | CaO19_6557 | hypothetical protein |
Caenorhabditis elegans | CELE_B0218.2 | Protein FAAH-2 |
Caenorhabditis elegans | CELE_F58H7.2 | Protein FAAH-3 |
Caenorhabditis elegans | CELE_B0218.1 | Protein FAAH-1, isoform A |
Drosophila melanogaster | Dmel_CG7900 | CG7900 gene product from transcript CG7900-RB |
Drosophila melanogaster | Dmel_CG5112 | CG5112 gene product from transcript CG5112-RA |
Drosophila melanogaster | Dmel_CG7910 | CG7910 gene product from transcript CG7910-RA |
Echinococcus granulosus | EgrG_000674100 | fatty acid amide hydrolase 1 |
Echinococcus granulosus | EgrG_000743700 | fatty acid amide hydrolase 1 |
Echinococcus multilocularis | EmuJ_000674100 | fatty acid amide hydrolase 1 |
Echinococcus multilocularis | EmuJ_000743700 | fatty acid amide hydrolase 1 |
Homo sapiens | ENSG00000117480 | fatty acid amide hydrolase |
Loa Loa (eye worm) | LOAG_09182 | hypothetical protein |
Mus musculus | ENSMUSG00000034171 | fatty acid amide hydrolase |
Schistosoma japonicum | Sjp_0049780 | Fatty-acid amide hydrolase 1, putative |
Schistosoma japonicum | Sjp_0060310 | Fatty-acid amide hydrolase 1, putative |
Schistosoma japonicum | Sjp_0060320 | ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative |
Schistosoma mansoni | Smp_167750 | fatty-acid amide hydrolase |
Schistosoma mansoni | Smp_004220 | amidase |
Schmidtea mediterranea | mk4.006890.02 | Fatty-acid amide hydrolase 1 |
Schmidtea mediterranea | mk4.002051.04 | Fatty-acid amide hydrolase 1 |
Schmidtea mediterranea | mk4.000180.11 | Fatty-acid amide hydrolase 1 |
Schmidtea mediterranea | mk4.001109.00 | Fatty-acid amide hydrolase 1 |
Schmidtea mediterranea | mk4.005541.02 | Fatty-acid amide hydrolase 1 |
Schmidtea mediterranea | mk4.002975.02 | Fatty-acid amide hydrolase 1 |
Schmidtea mediterranea | mk4.002565.01 | |
Schmidtea mediterranea | mk4.001109.06 | Fatty-acid amide hydrolase 1 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Rattus norvegicus | Anandamide amidohydrolase | Compounds | References |
Mus musculus | fatty acid amide hydrolase | Compounds | References |
Homo sapiens | fatty acid amide hydrolase | Compounds | References |