Detailed information for compound 132550

Basic information

Technical information
  • TDR Targets ID: 132550
  • Name: 3-(4-fluorophenyl)pyrido[3,2-e][1,2,4]triazin e
  • MW: 226.209 | Formula: C12H7FN4
  • H donors: 0 H acceptors: 4 LogP: 1.65 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1nnc2c(n1)cccn2
  • InChi: 1S/C12H7FN4/c13-9-5-3-8(4-6-9)11-15-10-2-1-7-14-12(10)17-16-11/h1-7H
  • InChiKey: DAYMHSYYQPOVJS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 121845-91-8
  • 3-(4-Fluoro-phenyl)-pyrido(3,2-e)(1,2,4)triazine
  • 3-(4-Fluoro-phenyl)-pyrido[3,2-e][1,2,4]triazine
  • AIDS-195875
  • AIDS195875

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0143 0.0332
Echinococcus multilocularis GPCR, family 2 0.0031 0.0077 0.0087
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1618 0.8268 1
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.004 0.0122 0.0337
Plasmodium falciparum alpha/beta hydrolase, putative 0.0031 0.0077 0.0206
Loa Loa (eye worm) glutaminase 0.0268 0.1299 0.1566
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0111 0.0129
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0031 0.0077 0.0157
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0143 0.0332
Toxoplasma gondii phospholipase/carboxylesterase 0.004 0.0122 0.113
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0044 0.0143 0.1485
Brugia malayi Carboxylesterase family protein 0.0142 0.0647 0.0782
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0111 0.0256
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0009 0.0006
Mycobacterium ulcerans amidase 0.0195 0.0923 0.0917
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0403 0.1117
Echinococcus granulosus acetylcholinesterase 0.0142 0.0647 0.0777
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0039 0.0041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0111 0.0129
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0141
Brugia malayi MH2 domain containing protein 0.0018 0.0009 0.0011
Entamoeba histolytica hypothetical protein 0.004 0.0122 0.0269
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0123 0.0293
Schistosoma mansoni cpg binding protein 0.0098 0.0422 0.0505
Loa Loa (eye worm) hypothetical protein 0.003 0.0072 0.0081
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0632 0.3181 0.9317
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0038 0.0036
Plasmodium vivax PST-A protein 0.004 0.0122 0.0337
Mycobacterium ulcerans epoxide hydrolase EphF 0.0031 0.0077 0.007
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0403 0.11
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.0076 0.0086
Giardia lamblia Fructose-bisphosphate aldolase 0.0632 0.3181 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0403 0.1476
Brugia malayi UPF0017 protein CG3488 0.0031 0.0077 0.0093
Toxoplasma gondii hypothetical protein 0.004 0.0122 0.113
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0031 0.0077 0.0117
Leishmania major importin beta-1 subunit, putative 0.0025 0.0043 0.0035
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0195 0.0923 0.0917
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0294 0.035
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0242 0.1164 0.1181
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0129
Mycobacterium ulcerans amidase 0.0195 0.0923 0.0917
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0122
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0044 0.0143 0.0136
Echinococcus multilocularis neuroligin 0.0024 0.0039 0.0041
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0044 0.0143 0.04
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0031 0.0077 0.0137
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0009 0.0006
Brugia malayi beta-lactamase 0.0038 0.0111 0.0134
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0031 0.0077 0.0117
Chlamydia trachomatis hydrolase 0.004 0.0122 0.1253
Echinococcus granulosus thioredoxin glutathione reductase 0.0128 0.0577 0.0693
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0041
Mycobacterium ulcerans lysophospholipase 0.0677 0.3412 0.3407
Mycobacterium ulcerans hypothetical protein 0.0677 0.3412 0.3407
Echinococcus granulosus importin subunit beta 1 0.003 0.0072 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0122 0.0288
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0031 0.0077 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0403 0.1117
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0143 0.0332
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0077 0.0087
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0195 0.0923 0.0936
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0009 0.0006
Mycobacterium tuberculosis Possible lysophospholipase 0.0677 0.3412 0.3467
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0122 0.0269
Mycobacterium ulcerans haloalkane dehalogenase 0.0031 0.0077 0.007
Echinococcus multilocularis Phospholipase carboxylesterase 0.004 0.0122 0.0141
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0031 0.0077 0.0088
Echinococcus granulosus BC026374 protein S09 family 0.0024 0.0039 0.0041
Mycobacterium tuberculosis Conserved protein 0.0038 0.0111 0.0111
Treponema pallidum fructose-bisphosphate aldolase 0.0632 0.3181 1
Brugia malayi Carboxylesterase family protein 0.0024 0.0039 0.0047
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0041
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0044 0.0143 0.04
Trypanosoma brucei monoglyceride lipase, putative 0.0677 0.3412 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0122 0.0288
Mycobacterium ulcerans haloalkane dehalogenase 0.0031 0.0077 0.007
Echinococcus multilocularis fatty acid amide hydrolase 1 0.1618 0.8268 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0123 0.0274
Echinococcus granulosus abhydrolase domain containing 3 0.004 0.0122 0.0141
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0111 0.0256
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0038 0.0021
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0195 0.0923 0.1111
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0031 0.0077 0.0077
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0031 0.0077 0.0137
Brugia malayi alpha/beta hydrolase 0.0031 0.0077 0.0093
Schistosoma mansoni smad1 5 8 and 0.0018 0.0009 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0077 0.0077
Echinococcus multilocularis BC026374 protein (S09 family) 0.0024 0.0039 0.0041
Mycobacterium ulcerans hypothetical protein 0.0031 0.0077 0.007
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0031 0.0077 0.0137
Mycobacterium ulcerans glutaminase 0.0268 0.1299 0.1292
Brugia malayi amidase 0.1618 0.8268 1
Onchocerca volvulus 0.0038 0.0111 0.0296
Giardia lamblia Kinase, PLK 0.0094 0.0403 0.118
Toxoplasma gondii protein c14orf29, putative 0.004 0.0122 0.113
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0123 0.0293
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0122 0.0288
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0039 0.0038
Plasmodium vivax unspecified product 0.004 0.0122 0.0337
Brugia malayi RNA, U transporter 1 0.0086 0.0361 0.0436
Trypanosoma brucei monoglyceride lipase, putative 0.0677 0.3412 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0122 0.0337
Plasmodium falciparum esterase, putative 0.004 0.0122 0.0337
Plasmodium vivax alpha/beta hydrolase, putative 0.0031 0.0077 0.0206
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0123 0.0274
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0677 0.3412 1
Echinococcus multilocularis carboxylesterase 5A 0.0142 0.0647 0.0777
Schistosoma mansoni fatty-acid amide hydrolase 0.1618 0.8268 1
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0195 0.0923 0.0936
Echinococcus multilocularis acetylcholinesterase 0.0142 0.0647 0.0777
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0322 0.158 0.1604
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.0031 0.0077 0.0137
Plasmodium falciparum glutathione reductase 0.0044 0.0143 0.04
Schistosoma mansoni cpg binding protein 0.0093 0.0395 0.0472
Plasmodium falciparum prodrug activation and resistance esterase 0.004 0.0122 0.0337
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0122 0.0337
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0072 0.0122
Onchocerca volvulus Lipase homolog 0.0031 0.0077 0.0159
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0044 0.0143 0.0167
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0111 0.0256
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0031 0.0077 0.0088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0143 0.0332
Mycobacterium tuberculosis Putative ferredoxin reductase 0.029 0.1413 0.1434
Echinococcus granulosus abhydrolase domain containing protein 0.0031 0.0077 0.0088
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.029 0.1413 0.1434
Plasmodium falciparum thioredoxin reductase 0.0127 0.0572 0.1659
Mycobacterium ulcerans hypothetical protein 0.0031 0.0077 0.007
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0031 0.0077 0.0093
Echinococcus multilocularis abhydrolase domain containing protein 0.0031 0.0077 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0036 0.0034
Schistosoma mansoni ran 0.0022 0.0031 0.0031
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0632 0.3181 0.9317
Echinococcus granulosus para nitrobenzyl esterase 0.0024 0.0039 0.0041
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0031 0.0077 0.0077
Plasmodium vivax lysophospholipase, putative 0.004 0.0122 0.0337
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0038 0.0031
Mycobacterium tuberculosis Probable oxidoreductase 0.0322 0.158 0.1604
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0111 0.0111
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0031 0.0077 0.0077
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0195 0.0923 0.0936
Schistosoma mansoni ran 0.0022 0.0031 0.0031
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0195 0.0923 0.269
Leishmania major hydrolase, alpha/beta fold family, putative 0.0031 0.0077 0.0137
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0294 0.0796
Mycobacterium ulcerans oxidoreductase 0.0031 0.0077 0.007
Toxoplasma gondii alpha/beta hydrolase, putative 0.0031 0.0077 0.0577
Mycobacterium tuberculosis Probable dehydrogenase 0.029 0.1413 0.1434
Plasmodium vivax alpha/beta hydrolase, putative 0.004 0.0122 0.0337
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0195 0.0923 0.269
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0031 0.0031
Leishmania major trypanothione reductase 0.0127 0.0572 0.16
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0632 0.3181 0.9319
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0003
Brugia malayi CXXC zinc finger family protein 0.0093 0.0395 0.0478
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0031 0.0077 0.0157
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0195 0.0923 0.1111
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0122 0.0337
Mycobacterium tuberculosis Conserved protein 0.0038 0.0111 0.0111
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0046
Mycobacterium ulcerans lignin peroxidase LipJ 0.0031 0.0077 0.007
Mycobacterium ulcerans epoxide hydrolase EphA 0.0031 0.0077 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0128 0.0305
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0123 0.0143
Mycobacterium ulcerans epoxide hydrolase EphB 0.0031 0.0077 0.007
Plasmodium vivax PST-A protein 0.004 0.0122 0.0337
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0111 0.0104
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0038 0.0021
Trypanosoma brucei polo-like protein kinase 0.0094 0.0403 0.11
Plasmodium vivax lysophospholipase, putative 0.004 0.0122 0.0337
Mycobacterium ulcerans epoxide hydrolase EphE 0.0031 0.0077 0.007
Mycobacterium ulcerans exported protease 0.0031 0.0077 0.007
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0031 0.0077 0.0088
Schistosoma mansoni gliotactin 0.0024 0.0039 0.0041
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0077 0.0087
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0425 0.0508
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0047 0.0051
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0143 0.0332
Plasmodium vivax unspecified product 0.004 0.0122 0.0337
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0229 0.0271
Leishmania major hypothetical protein, conserved 0.0038 0.0111 0.0237
Onchocerca volvulus 0.0502 0.2509 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0195 0.0923 0.1111
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0309 0.1511 0.4365
Brugia malayi chromobox protein homolog 3 0.0041 0.0128 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0403 0.1117
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0128 0.0305
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0041
Loa Loa (eye worm) carboxylesterase 0.0024 0.0039 0.0041
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0111 0.0111
Mycobacterium tuberculosis Conserved protein 0.0031 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0003
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0123 0.0293
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0031 0.0077 0.0088
Plasmodium falciparum epoxide hydrolase 1 0.0031 0.0077 0.0206
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0038 0.0031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0632 0.3181 0.9319
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0123 0.0293
Loa Loa (eye worm) hydrolase 0.0031 0.0077 0.0088
Trypanosoma cruzi amidase, putative 0.0195 0.0923 0.2639
Echinococcus granulosus acetylcholinesterase 0.0142 0.0647 0.0777
Trypanosoma cruzi amidase, putative 0.0195 0.0923 0.2639
Plasmodium vivax PST-A protein 0.0677 0.3412 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0123 0.0274
Echinococcus granulosus chromobox protein 1 0.0073 0.0294 0.035
Echinococcus granulosus Phospholipase carboxylesterase 0.004 0.0122 0.0141
Toxoplasma gondii hypothetical protein 0.004 0.0122 0.113
Trypanosoma cruzi serine peptidase, putative 0.004 0.0122 0.0269
Brugia malayi Thioredoxin reductase 0.0127 0.0572 0.0692
Mycobacterium ulcerans hydrolase 0.0031 0.0077 0.007
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0309 0.1511 0.1534
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0087
Plasmodium falciparum exported lipase 2 0.004 0.0122 0.0337
Brugia malayi beta-lactamase family protein 0.0038 0.0111 0.0134
Onchocerca volvulus 0.0024 0.0039 0.0005
Toxoplasma gondii NADPH-glutathione reductase 0.0044 0.0143 0.1394
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0031 0.0077 0.0088
Mycobacterium ulcerans peptide amidase, GatA 0.0195 0.0923 0.0917
Brugia malayi MGC79044 protein 0.004 0.0122 0.0147
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0322 0.158 0.1604
Brugia malayi putative amidase 0.0195 0.0923 0.1117
Brugia malayi hydrolase, alpha/beta fold family protein 0.0031 0.0077 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0425 0.0514
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.004 0.0122 0.0269
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0111 0.0111
Trichomonas vaginalis hydrolase, putative 0.0031 0.0077 0.0157
Loa Loa (eye worm) thioredoxin reductase 0.0127 0.0572 0.0686
Plasmodium falciparum lysophospholipase, putative 0.0677 0.3412 1
Trypanosoma brucei trypanothione reductase 0.0127 0.0572 0.16
Leishmania major hypothetical protein, conserved 0.0031 0.0077 0.0137
Brugia malayi Carboxylesterase family protein 0.0024 0.0039 0.0047
Mycobacterium ulcerans amidase 0.0195 0.0923 0.0917
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0044 0.0143 0.04
Plasmodium falciparum esterase, putative 0.0677 0.3412 1
Plasmodium falciparum epoxide hydrolase 2 0.004 0.0122 0.0337
Entamoeba histolytica hypothetical protein 0.004 0.0122 0.0269
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0077 0.0206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0632 0.3181 0.9319
Brugia malayi Protein C20orf22 0.004 0.0122 0.0147
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0086 0.0183
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0122 0.0122
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.0047 0.0051
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0294 0.0796
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0195 0.0923 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0143 0.0332
Mycobacterium ulcerans hydrolase 0.0031 0.0077 0.007
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0038 0.0031
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0264 0.0319
Echinococcus granulosus monoacylglycerol lipase abhd12 0.004 0.0122 0.0141
Echinococcus granulosus snurportin 1 0.0324 0.1586 0.1914
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0043 0.0054
Echinococcus multilocularis Smad4 0.0018 0.0009 0.0006
Plasmodium vivax importin-beta 2, putative 0.003 0.0072 0.0191
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0088
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.029 0.1413 0.4074
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0141
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0111 0.0129
Plasmodium falciparum lysophospholipase, putative 0.004 0.0122 0.0337
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.004
Brugia malayi MH2 domain containing protein 0.0018 0.0009 0.0011
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0122 0.0288
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0031 0.0077 0.0137
Loa Loa (eye worm) acetylcholinesterase 1 0.0142 0.0647 0.0777
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.004
Schistosoma mansoni smad 0.0018 0.0009 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0123 0.0293
Loa Loa (eye worm) beta-lactamase 0.0038 0.0111 0.0129
Echinococcus granulosus GPCR family 2 0.0031 0.0077 0.0087
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.0028 0.0011
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0195 0.0923 0.2623
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0122 0.0269
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0632 0.3181 0.9319
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0143 0.0332
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0425 0.0514
Schistosoma mansoni peptidase 0.004 0.0122 0.0141
Brugia malayi CHD4 protein 0.0017 0.0005 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0122 0.0288
Brugia malayi glutathione reductase 0.0127 0.0572 0.0692
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0122 0.0288
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0122 0.0288
Giardia lamblia Cgi67 serine protease precursor-like protein 0.004 0.0122 0.0289
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0032 0.0083 0.01
Echinococcus multilocularis importin subunit beta 1 0.003 0.0072 0.0081
Mycobacterium tuberculosis Probable reductase 0.029 0.1413 0.1434
Plasmodium falciparum lysophospholipase, putative 0.0677 0.3412 1
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.0122 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0003
Plasmodium vivax lysophospholipase, putative 0.004 0.0122 0.0337
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0044 0.0143 0.0136
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0403 0.0481
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0632 0.3181 0.9319
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0252 0.0299
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0088
Trichomonas vaginalis esterase, putative 0.0038 0.0111 0.0256
Onchocerca volvulus 0.0038 0.0111 0.0296
Schistosoma mansoni chromobox protein 0.0073 0.0294 0.035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0038 0.0021
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.3412 1
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.0011
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.004 0.0122 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0077 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0157 0.0391
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0086 0.0183
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0031 0.0077 0.0159
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0044 0.0143 0.0332
Schistosoma mansoni hypothetical protein 0.0067 0.0264 0.0313
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0032 0.0083 0.01
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.0011
Trichomonas vaginalis glutathione reductase, putative 0.0044 0.0143 0.0351
Plasmodium falciparum esterase, putative 0.004 0.0122 0.0337
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.3412 1
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0031 0.0077 0.0088
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0044 0.0143 0.0332
Echinococcus granulosus smad 0.0018 0.0009 0.0006
Plasmodium vivax hypothetical protein, conserved 0.004 0.0122 0.0337
Schistosoma mansoni alpha-glucosidase 0.0156 0.0721 0.0867
Echinococcus multilocularis smad 0.0018 0.0009 0.0006
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0043 0.0035
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0087
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0122 0.0288
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0142 0.0647 0.0777
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0122 0.0288
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0195 0.0923 0.2568
Trypanosoma cruzi serine peptidase, putative 0.004 0.0122 0.0269
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0044 0.0143 0.0173
Leishmania major monoglyceride lipase, putative 0.0677 0.3412 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0039 0.0041
Loa Loa (eye worm) histone methyltransferase 0.0031 0.0076 0.0086
Brugia malayi Pre-SET motif family protein 0.0441 0.2195 0.2655
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0441 0.2195 0.2651
Echinococcus multilocularis acetylcholinesterase 0.0142 0.0647 0.0777
Brugia malayi hypothetical protein 0.0024 0.0039 0.0047
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0031 0.0077 0.0157
Mycobacterium ulcerans proline iminopeptidase PIP 0.0031 0.0077 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0252 0.0299
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0195 0.0923 0.0936
Mycobacterium ulcerans amidase 0.0195 0.0923 0.0917
Brugia malayi glutaminase DH11.1 0.0268 0.1299 0.1571
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0322 0.158 0.4569
Plasmodium vivax PST-A protein 0.004 0.0122 0.0337
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0403 0.11
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0123 0.0143
Schistosoma mansoni alpha glucosidase 0.004 0.0123 0.0143
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0038 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0252 0.0299
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0086 0.0183
Trichomonas vaginalis spcc417.12 protein, putative 0.0024 0.0039 0.0044
Echinococcus granulosus cpg binding protein 0.0098 0.0422 0.0505
Echinococcus multilocularis thioredoxin glutathione reductase 0.0128 0.0577 0.0693
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0072 0.0122
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0195 0.0923 0.2639
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0122 0.0288
Plasmodium falciparum glutathione reductase 0.0127 0.0572 0.1659
Schistosoma mansoni Smad4 0.0018 0.0009 0.0006
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0072 0.0513
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.004 0.0122 0.113
Echinococcus granulosus neuroligin 0.0024 0.0039 0.0041
Mycobacterium ulcerans beta-lactamase 0.0038 0.0111 0.0104
Mycobacterium tuberculosis Carboxylesterase LipT 0.0024 0.0039 0.0038
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0077 0.0137
Trichomonas vaginalis mercuric reductase, putative 0.0044 0.0143 0.0351
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0093
Echinococcus granulosus abhydrolase domain containing protein 13 0.004 0.0122 0.0141
Schistosoma mansoni acetylcholinesterase 0.0024 0.0039 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0632 0.3181 0.9319
Brugia malayi Carboxylesterase family protein 0.0142 0.0647 0.0782
Onchocerca volvulus 0.0024 0.0039 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0077 0.0206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0143 0.0332
Plasmodium vivax PST-A protein 0.004 0.0122 0.0337
Echinococcus granulosus chromobox protein 1 0.0073 0.0294 0.035
Leishmania major hydrolase, alpha/beta fold family-like protein 0.0031 0.0077 0.0137
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.0122 0.113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0252 0.0299
Schistosoma mansoni amidase 0.1618 0.8268 1
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.3412 1
Chlamydia trachomatis acyltransferase family protein 0.004 0.0122 0.1253
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0031 0.0077 0.0088
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0677 0.3412 1
Mycobacterium ulcerans peroxidase BpoB 0.0031 0.0077 0.007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0038 0.0021
Echinococcus granulosus abhydrolase domain containing protein 11 0.0031 0.0077 0.0088
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0024 0.0039 0.0041
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0044 0.0143 0.0167
Trypanosoma cruzi monoglyceride lipase, putative 0.0677 0.3412 1
Plasmodium falciparum alpha/beta-hydrolase, putative 0.004 0.0122 0.0337
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0123 0.0293
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.0077 0.007
Schistosoma mansoni importin beta-1 0.003 0.0072 0.0081
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.004 0.0122 0.0269
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0123 0.0293
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.3412 1
Brugia malayi Amidase family protein 0.0195 0.0923 0.1117
Toxoplasma gondii histone lysine methyltransferase SET1 0.0178 0.0836 1
Toxoplasma gondii thioredoxin reductase 0.0127 0.0572 0.6723
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.004 0.0122 0.0269
Toxoplasma gondii phospholipase 0.004 0.0122 0.113
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0009 0.0006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.0076 0.0086
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0031 0.0077 0.0088
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.004 0.0122 0.113
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0044 0.0143 0.0332
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0007 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0403 0.0481
Entamoeba histolytica hypothetical protein 0.0025 0.0043 0.0035
Schistosoma mansoni cpg binding protein 0.0098 0.0422 0.0505
Leishmania major hypothetical protein, conserved 0.004 0.0122 0.0269
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0031 0.0077 0.0117
Leishmania major hypothetical protein, conserved 0.0031 0.0077 0.0137
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0038 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0077 0.0087
Brugia malayi Heterochromatin protein 1 0.0073 0.0294 0.0355
Trypanosoma cruzi hydrolase-like protein, putative 0.0031 0.0077 0.0137
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0122 0.0337
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0031 0.0077 0.0577
Plasmodium vivax thioredoxin reductase, putative 0.0127 0.0572 0.1659
Echinococcus granulosus abhydrolase domain containing protein 3 0.0031 0.0077 0.0088
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0031 0.0031
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0144 0.0353
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0041
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0123 0.0149
Plasmodium vivax alpha/beta hydrolase, putative 0.004 0.0122 0.0337
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0129
Mycobacterium ulcerans lipase/esterase 0.0031 0.0077 0.007
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0031 0.0077 0.0077
Toxoplasma gondii ABC1 family protein 0.0038 0.0111 0.0997
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.0047 0.0051
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0309 0.1511 0.1505
Echinococcus granulosus Smad4 0.0018 0.0009 0.0006
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0031 0.007
Mycobacterium leprae Probable lipase LipE 0.0038 0.0111 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0086 0.0183
Giardia lamblia ENC6 protein 0.0031 0.0077 0.0147
Plasmodium vivax glutathione reductase, putative 0.0127 0.0572 0.1659
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0031 0.0077 0.0157
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0127 0.0572 0.0579
Leishmania major hypothetical protein, conserved 0.004 0.0122 0.0269
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0086 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0086 0.0183
Plasmodium vivax hypothetical protein, conserved 0.004 0.0122 0.0337
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0024 0.0039 0.0038
Brugia malayi hydrolase, alpha/beta fold family protein 0.0031 0.0077 0.0093
Loa Loa (eye worm) glutathione reductase 0.0127 0.0572 0.0686
Leishmania major hydrolase-like protein 0.0031 0.0077 0.0137
Brugia malayi Carboxylesterase family protein 0.0024 0.0039 0.0047
Loa Loa (eye worm) carboxylesterase 0.0024 0.0039 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0123 0.0274
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0047 0.0051
Echinococcus granulosus fatty acid amide hydrolase 1 0.1618 0.8268 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.004
Brugia malayi Amidase family protein 0.0195 0.0923 0.1117
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0111 0.0237
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0031 0.0077 0.0077
Echinococcus granulosus carboxylesterase 5A 0.0142 0.0647 0.0777
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0403 0.0487
Mycobacterium ulcerans hypothetical protein 0.0038 0.0111 0.0104
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0038 0.0036
Onchocerca volvulus 0.0024 0.0039 0.0005
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0111 0.0217
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0044 0.0143 0.0332
Toxoplasma gondii hypothetical protein 0.004 0.0122 0.113
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0038 0.0046
Echinococcus granulosus dnaJ subfamily B 0.0914 0.4633 0.5601
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0677 0.3412 1
Mycobacterium ulcerans amidase 0.0195 0.0923 0.0917
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0009 0.0006
Schistosoma mansoni glutaminase 0.0268 0.1299 0.1566
Trichomonas vaginalis ran, putative 0.0022 0.0031 0.0019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0041
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.004 0.0122 0.0269
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0111 0.0134
Brugia malayi MGC83647 protein 0.004 0.0122 0.0147
Schistosoma mansoni smad1 5 8 and 0.0018 0.0009 0.0006
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.004 0.0122 0.0269
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0111 0.0237
Mycobacterium ulcerans hypothetical protein 0.0031 0.0077 0.007
Mycobacterium ulcerans bromoperoxidase BpoC 0.0031 0.0077 0.007
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0111 0.0256
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0195 0.0923 0.2623
Plasmodium falciparum exported lipase 1 0.004 0.0122 0.0337
Trypanosoma cruzi hydrolase-like protein, putative 0.0031 0.0077 0.0137
Echinococcus granulosus fatty acid amide hydrolase 1 0.0195 0.0923 0.1111
Trypanosoma cruzi hydrolase-like protein 0.0031 0.0077 0.0137
Giardia lamblia NADH oxidase lateral transfer candidate 0.0044 0.0143 0.0356
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0077 0.0313 0.0373
Mycobacterium ulcerans lipase/esterase 0.0031 0.0077 0.007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0128 0.0149
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0044 0.0143 0.0332
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0044 0.0143 0.0332
Brugia malayi Carboxylesterase family protein 0.0024 0.0039 0.0047
Mycobacterium ulcerans exported protease 0.0031 0.0077 0.007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0043 0.0054
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0077 0.0093
Brugia malayi MH2 domain containing protein 0.0267 0.1292 0.1563
Mycobacterium ulcerans acyl-CoA synthetase 0.0032 0.0082 0.0075
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0403 0.11
Brugia malayi beta-lactamase family protein 0.0038 0.0111 0.0134
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0031 0.0077 0.0157
Echinococcus granulosus fatty acid amide hydrolase 1 0.1618 0.8268 1
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.1292 0.1558
Brugia malayi Glycosyl hydrolases family 31 protein 0.0181 0.0852 0.103
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0199 0.0944 0.1137
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0122 0.0288
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0038 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0077 0.0206
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0031 0.0077 0.0088
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.3412 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0024 0.0039 0.0041
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0403 0.0481
Schistosoma mansoni neuroligin 3 (S09 family) 0.0024 0.0039 0.0041
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0137
Loa Loa (eye worm) hypothetical protein 0.0099 0.0425 0.0508
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0031 0.0077 0.0157
Schistosoma mansoni hydrolase 0.0031 0.0077 0.0088
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.004 0.0122 0.0269
Plasmodium falciparum thioredoxin reductase 0.0044 0.0143 0.04
Schistosoma mansoni kinase 0.0048 0.0163 0.0192
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0403 0.0481
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0031 0.0077 0.0077
Loa Loa (eye worm) CXXC zinc finger family protein 0.0093 0.0395 0.0472
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0065 0.0252 0.0299
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0632 0.3181 0.9319
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.029 0.1413 0.1434
Echinococcus multilocularis snurportin 1 0.0324 0.1586 0.1914
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0086 0.0183
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0037
Mycobacterium ulcerans carboxylesterase, LipT 0.0024 0.0039 0.0032
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0122 0.0337
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0009 0.0006
Mycobacterium leprae Probable exported protease 0.0031 0.0077 0.0117
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0252 0.0299
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0122 0.0288
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.0122 0.0141
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.004 0.0122 0.0141
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0077 0.0093
Loa Loa (eye worm) hypothetical protein 0.0142 0.0647 0.0777
Brugia malayi Pre-SET motif family protein 0.0065 0.0252 0.0304
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0003
Mycobacterium tuberculosis Probable exported protease 0.0031 0.0077 0.0077
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0123 0.115
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0031 0.0077 0.0077
Loa Loa (eye worm) amidase 0.0195 0.0923 0.1111
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0403 0.1117
Trichomonas vaginalis set domain proteins, putative 0.0502 0.2509 0.7333
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0111 0.0104
Mycobacterium ulcerans hypothetical protein 0.004 0.0122 0.0115
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0044 0.0143 0.1394
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0031 0.0077 0.0157
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0077 0.0087
Loa Loa (eye worm) carboxylesterase 0.0142 0.0647 0.0777
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0195 0.0923 0.1111
Schistosoma mansoni chromobox protein 0.0073 0.0294 0.035
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.004 0.0122 0.0288
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0111 0.0111
Onchocerca volvulus 0.0024 0.0039 0.0005
Leishmania major hypothetical protein, conserved 0.0195 0.0923 0.2639
Leishmania major hydrolase-like protein,esterase-like protein 0.0031 0.0077 0.0137
Loa Loa (eye worm) hypothetical protein 0.0142 0.0647 0.0777
Schistosoma mansoni hypothetical protein 0.0324 0.1586 0.1914
Loa Loa (eye worm) Smad1 0.0018 0.0009 0.0006
Echinococcus granulosus lysosomal alpha glucosidase 0.0181 0.0852 0.1025
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0122 0.0288
Mycobacterium tuberculosis Conserved protein 0.0038 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0122 0.0288
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0003
Mycobacterium ulcerans hydrolase 0.004 0.0122 0.0115
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0031 0.0077 0.0206
Trypanosoma brucei glucosidase, putative 0.004 0.0123 0.0274
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0039 0.0041
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.3412 1
Entamoeba histolytica ;Alias 0.004 0.0122 0.0269
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0123 0.0293
Mycobacterium ulcerans hypothetical protein 0.004 0.0122 0.0115
Brugia malayi Smad1 0.0018 0.0009 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.1292 0.1558
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0074 0.009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0047 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0143 0.0332
Plasmodium vivax PST-A protein 0.004 0.0122 0.0337
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0141
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0677 0.3412 1
Schistosoma mansoni smad1 5 8 and 0.0018 0.0009 0.0006
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0123 0.0293
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0122 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0122 0.0288
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0129
Mycobacterium ulcerans hypothetical protein 0.0031 0.0077 0.007
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0038 0.0031
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0024 0.0039 0.0041
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.004 0.0122 0.0288
Toxoplasma gondii peptidase S15, putative 0.004 0.0122 0.113
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0403 0.1117
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0852 0.1025
Mycobacterium ulcerans hypothetical protein 0.0024 0.0038 0.0031
Mycobacterium tuberculosis 4,9-DHSA hydrolase 0.1922 0.9838 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0038 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0123 0.0274
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0031 0.0077 0.007
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0195 0.0923 1
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0144 0.0353
Loa Loa (eye worm) hypothetical protein 0.0038 0.0111 0.0129
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0111 0.0306
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0077 0.0087
Loa Loa (eye worm) amidase 0.0195 0.0923 0.1111
Loa Loa (eye worm) hypothetical protein 0.0067 0.0264 0.0313
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0024 0.0039 0.0044
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0111 0.0111
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0252 0.2743
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0677 0.3412 1
Echinococcus multilocularis cpg binding protein 0.0098 0.0422 0.0505
Schistosoma mansoni BC026374 protein (S09 family) 0.0024 0.0039 0.0041
Plasmodium falciparum importin beta, putative 0.003 0.0072 0.0191
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0033 0.0086 0.0183
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0111 0.0129
Plasmodium falciparum BEM46-like protein, putative 0.004 0.0122 0.0337
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0403 0.11
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.004 0.0122 0.0269
Loa Loa (eye worm) glutaminase 2 0.0268 0.1299 0.1566
Plasmodium falciparum alpha/beta hydrolase, putative 0.004 0.0122 0.0337
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0111 0.0237
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0128 0.0363
Mycobacterium ulcerans lipase LipD 0.0038 0.0111 0.0104
Brugia malayi Importin beta-1 subunit 0.003 0.0072 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0041
Onchocerca volvulus 0.0024 0.0039 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0157 0.0391
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0031 0.0077 0.0077
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0181 0.0852 0.1025
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0031
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0044 0.0143 0.0167
Plasmodium vivax SET domain protein, putative 0.0065 0.0252 0.0718
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0031 0.0077 0.0077
Echinococcus multilocularis lysosomal alpha glucosidase 0.0181 0.0852 0.1025
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0031 0.0077 0.0077
Onchocerca volvulus 0.0105 0.0457 0.1697
Echinococcus multilocularis abhydrolase domain containing 3 0.0031 0.0077 0.0088
Onchocerca volvulus 0.0077 0.0313 0.1115
Trypanosoma cruzi trypanothione reductase, putative 0.0127 0.0572 0.16
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0123 0.0143
Echinococcus multilocularis chromobox protein 1 0.0073 0.0294 0.035
Loa Loa (eye worm) hypothetical protein 0.004 0.0122 0.0141
Onchocerca volvulus 0.0032 0.0082 0.0178
Echinococcus multilocularis chromobox protein 1 0.0073 0.0294 0.035
Brugia malayi Alpha/beta hydrolase 0.0031 0.0077 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0111 0.0256
Mycobacterium leprae Probable exported protease 0.0031 0.0077 0.0117
Plasmodium falciparum lysophospholipase, putative 0.004 0.0122 0.0337
Schistosoma mansoni hypothetical protein 0.0914 0.4633 0.5601
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0632 0.3181 0.9319
Loa Loa (eye worm) hypothetical protein 0.1618 0.8268 1
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0077 0.0137
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0031 0.0077 0.0117
Onchocerca volvulus Lipase homolog 0.0031 0.0077 0.0159
Schistosoma mansoni fatty-acid amide hydrolase 0.0195 0.0923 0.1111
Echinococcus multilocularis abhydrolase domain containing 3 0.004 0.0122 0.0141
Onchocerca volvulus 0.0093 0.0395 0.1445
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0403 0.1117
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.1586 0.1914
Plasmodium falciparum lysophospholipase, putative 0.0677 0.3412 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0044 0.0143 0.0332
Echinococcus multilocularis dnaJ subfamily B 0.0914 0.4633 0.5601
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0144 0.0428
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.029 0.1413 0.1434
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0031 0.0077 0.0137
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0111 0.0129
Trichomonas vaginalis glutaminase, putative 0.0268 0.1299 0.3761
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0044 0.0143 0.0143
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0195 0.0923 0.0936
Leishmania major hydrolase-like protein,esterase-like protein 0.0031 0.0077 0.0137
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0043 0.0054
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0044 0.0143 0.0332
Toxoplasma gondii hypothetical protein 0.004 0.0122 0.113
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0403 0.1117
Schistosoma mansoni alpha-glucosidase 0.0156 0.0721 0.0867
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0044 0.0143 0.0136
Onchocerca volvulus 0.0038 0.0111 0.0296
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0044 0.0143 0.04
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0009 0.0006
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0038 0.0031
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0252 0.0299

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 16 ug ml-1 Antifungal activity of the compound against Aspergillus niger; Range is 16-128 ChEMBL. 2810336
MIC (functional) = 32 ug ml-1 Antifungal activity of the compound against Trychophyton mentagrophytes ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Candida albicans ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Candida tropicalis ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity against Candida pseudotropicalis ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Candida rugosa ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Candida stellatoidea ChEMBL. 2810336
MIC (functional) > 128 ug ml-1 Antifungal activity against Trychophyton rubrum ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Candida albicans ChEMBL. 2810336
MIC (functional) = 128 ug ml-1 Antifungal activity of the compound against Candida stellatoidea ChEMBL. 2810336

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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