TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 294.349 | Formula: C14H22N4O3
H donors: 0 H acceptors: 3 LogP: 1.15 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cnn(c1)C(=O)N1CCN(CC1)C(=O)OC(C)(C)C
InChi: 1S/C14H22N4O3/c1-11-9-15-18(10-11)12(19)16-5-7-17(8-6-16)13(20)21-14(2,3)4/h9-10H,5-8H2,1-4H3
InChiKey: HJQWRDQCFRVZTL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Anandamide amidohydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	fatty-acid amide hydrolase	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative	Get druggable targets OG5_127783	All targets in OG5_127783
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.7 %
Echinococcus multilocularis	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.3 %
Onchocerca volvulus		Anandamide amidohydrolase	579 aa	539 aa	34.7 %
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Anandamide amidohydrolase	579 aa	499 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0088	0.6544	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Toxoplasma gondii	oxidoreductase, putative	0.0088	0.6544	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0088	0.6544	1
Leishmania major	short chain dehydrogenase/reductase, putative	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Leishmania major	dehydrogenase-like protein	0.0088	0.6544	1
Leishmania major	3-keto-dihydrosphingosine reductase	0.0088	0.6544	1
Leishmania major	short chain dehydrogenase-like protein	0.0088	0.6544	1
Schistosoma mansoni	amidase	0.0123	1	1
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0088	0.6544	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0088	0.6544	1
Onchocerca volvulus		0.0088	0.6544	0.5
Leishmania major	hypothetical protein, conserved	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Toxoplasma gondii	oxidoreductase, putative	0.0088	0.6544	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Entamoeba histolytica	short chain dehydrogenase family protein	0.0088	0.6544	0.5
Entamoeba histolytica	hypothetical protein	0.0088	0.6544	0.5
Onchocerca volvulus		0.0088	0.6544	0.5
Loa Loa (eye worm)	hypothetical protein	0.0123	1	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0088	0.6544	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0088	0.6544	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0088	0.6544	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0088	0.6544	0.5
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0088	0.6544	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Mycobacterium ulcerans	dehydrogenase/reductase	0.0088	0.6544	1
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0088	0.6544	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0088	0.6544	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0088	0.6544	1
Leishmania major	quinonoid dihydropteridine reductase	0.0088	0.6544	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0088	0.6544	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0088	0.6544	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0088	0.6544	0.5
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0088	0.6544	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Onchocerca volvulus		0.0088	0.6544	0.5
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0088	0.6544	0.6544
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0088	0.6544	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Loa Loa (eye worm)	oxidoreductase	0.0088	0.6544	0.6544
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Leishmania major	quinonoid dihydropteridine reductase	0.0088	0.6544	1
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0088	0.6544	0.5
Brugia malayi	Dehydrogenases, short chain protein 2	0.0088	0.6544	0.6544
Mycobacterium tuberculosis	Probable oxidoreductase	0.0088	0.6544	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0088	0.6544	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0088	0.6544	1
Leishmania major	hypothetical protein, conserved	0.0088	0.6544	1
Onchocerca volvulus		0.0088	0.6544	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0088	0.6544	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0088	0.6544	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0088	0.6544	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0088	0.6544	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0088	0.6544	1
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0088	0.6544	1
Brugia malayi	Dehydrogenases, short chain protein 30	0.0088	0.6544	0.6544
Loa Loa (eye worm)	oxidoreductase	0.0088	0.6544	0.6544
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0088	0.6544	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0088	0.6544	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0088	0.6544	0.5
Brugia malayi	dehydrogenases, short chain protein 2	0.0088	0.6544	0.6544
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0088	0.6544	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Loa Loa (eye worm)	oxidoreductase	0.0088	0.6544	0.6544
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0088	0.6544	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0088	0.6544	0.5
Loa Loa (eye worm)	oxidoreductase	0.0088	0.6544	0.6544
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0088	0.6544	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Toxoplasma gondii	carbonyl reductase 1, putative	0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0088	0.6544	0.5
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0088	0.6544	0.6544
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0088	0.6544	1
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0088	0.6544	0.5
Leishmania major	oxidoreductase-like protein	0.0088	0.6544	1
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0088	0.6544	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0088	0.6544	1
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0088	0.6544	1
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0088	0.6544	0.5
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0088	0.6544	1
Plasmodium vivax	hypothetical protein, conserved	0.0088	0.6544	0.5
Onchocerca volvulus	Sepiapterin reductase homolog	0.0088	0.6544	0.5
Schistosoma mansoni	fatty-acid amide hydrolase	0.0123	1	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0088	0.6544	1
Mycobacterium leprae	Probable oxidoreductase	0.0088	0.6544	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0088	0.6544	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0088	0.6544	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.6544	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0088	0.6544	0.5
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.5
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0088	0.6544	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0035	0.1211	0.1211
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0088	0.6544	1
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0088	0.6544	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Giardia lamblia	Reductase, putative	0.0088	0.6544	0.5
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0088	0.6544	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0088	0.6544	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Leishmania major	quinonoid dihydropteridine reductase	0.0088	0.6544	1
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0088	0.6544	0.5
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0123	1	1
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0088	0.6544	0.5
Leishmania major	short chain dehydrogenase, putative	0.0088	0.6544	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0088	0.6544	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0123	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0088	0.6544	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0088	0.6544	1
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0088	0.6544	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0088	0.6544	1
Onchocerca volvulus		0.0088	0.6544	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Onchocerca volvulus		0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0088	0.6544	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0088	0.6544	0.5
Onchocerca volvulus		0.0088	0.6544	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0088	0.6544	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.6544	1
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0088	0.6544	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0088	0.6544	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Brugia malayi	Retinol dehydrogenase 12	0.0088	0.6544	0.6544
Leishmania major	short chain dehydrogenase, putative	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0088	0.6544	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0088	0.6544	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0088	0.6544	0.5
Mycobacterium ulcerans	oxidoreductase	0.0088	0.6544	1
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0088	0.6544	1
Brugia malayi	oxidoreductase	0.0088	0.6544	0.6544
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0088	0.6544	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0123	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Onchocerca volvulus		0.0088	0.6544	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Onchocerca volvulus		0.0088	0.6544	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Loa Loa (eye worm)	oxidoreductase	0.0088	0.6544	0.6544
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0088	0.6544	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0088	0.6544	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0088	0.6544	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Leishmania major	hypothetical protein, conserved	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Mycobacterium ulcerans	dehydrogenase	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Leishmania major	quinonoid dihydropteridine reductase	0.0088	0.6544	1
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0088	0.6544	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Leishmania major	quinonoid dihydropteridine reductase	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0088	0.6544	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0088	0.6544	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0088	0.6544	0.5
Loa Loa (eye worm)	dehydrogenase	0.0088	0.6544	0.6544
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Loa Loa (eye worm)	oxidoreductase	0.0088	0.6544	0.6544
Plasmodium falciparum	steroid dehydrogenase, putative	0.0088	0.6544	0.5
Loa Loa (eye worm)	oxidoreductase	0.0088	0.6544	0.6544
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Onchocerca volvulus		0.0088	0.6544	0.5
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0088	0.6544	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0088	0.6544	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0088	0.6544	1
Leishmania major	hypothetical protein, conserved	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.6544	1
Mycobacterium ulcerans	ketoacyl reductase	0.0088	0.6544	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0088	0.6544	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0088	0.6544	1
Brugia malayi	Cytochrome P450 family protein	0.0035	0.1211	0.1211
Entamoeba histolytica	short chain dehydrogenase family protein	0.0088	0.6544	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0088	0.6544	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0088	0.6544	0.5
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0088	0.6544	0.6544
Giardia lamblia	Short-chain dehydrogenase, putative	0.0088	0.6544	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0088	0.6544	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0088	0.6544	0.5
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0123	1	1
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0088	0.6544	0.5
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0088	0.6544	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0088	0.6544	0.5
Loa Loa (eye worm)	oxidoreductase	0.0088	0.6544	0.6544
Loa Loa (eye worm)	hypothetical protein	0.0088	0.6544	0.6544
Mycobacterium ulcerans	oxidoreductase	0.0088	0.6544	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0088	0.6544	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0088	0.6544	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0088	0.6544	1
Entamoeba histolytica	hypothetical protein, conserved	0.0088	0.6544	0.5
Onchocerca volvulus		0.0088	0.6544	0.5
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0088	0.6544	1
Brugia malayi	hypothetical protein	0.0088	0.6544	0.6544
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0088	0.6544	0.6544
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Brugia malayi	dehydrogenases, short chain protein 9	0.0088	0.6544	0.6544
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0088	0.6544	1
Leishmania major	pteridine reductase 1	0.0088	0.6544	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0088	0.6544	1
Brugia malayi	hypothetical protein	0.0088	0.6544	0.6544
Trypanosoma cruzi	hypothetical protein, conserved	0.0088	0.6544	1
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0088	0.6544	1
Loa Loa (eye worm)	dehydrogenase	0.0088	0.6544	0.6544
Onchocerca volvulus		0.0088	0.6544	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Onchocerca volvulus		0.0088	0.6544	0.5
Loa Loa (eye worm)	oxidoreductase	0.0088	0.6544	0.6544
Giardia lamblia	Hypothetical protein	0.0088	0.6544	0.5
Leishmania major	hypothetical protein, conserved	0.0088	0.6544	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0088	0.6544	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0088	0.6544	1
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0088	0.6544	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0088	0.6544	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0088	0.6544	1
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0088	0.6544	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Leishmania major	quinonoid dihydropteridine reductase	0.0088	0.6544	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0088	0.6544	0.6544
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0088	0.6544	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 850 nM	Inhibition of recombinant rat FAAH preincubated for 3 hrs	ChEMBL.	25037918

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3318592

Bibliographic References

No literature references available for this target.

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Detailed information for compound 921081