TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 394.255 | Formula: C17H17Cl2N5O2
H donors: 1 H acceptors: 3 LogP: 4.11 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)c(NCc1ccco1)nc(n2)n1cncc1.Cl.Cl
InChi: 1S/C17H15N5O2.2ClH/c1-23-12-4-5-15-14(9-12)16(19-10-13-3-2-8-24-13)21-17(20-15)22-7-6-18-11-22;;/h2-9,11H,10H2,1H3,(H,19,20,21);2*1H
InChiKey: GMBYFHZUUQFJIK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0027	0.0016
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.0027	0.0016
Mycobacterium leprae	putative cytochrome p450	0.0128	0.0357	0.0706
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0027	0.0016
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.0027	0.0016
Echinococcus granulosus	sex peptide receptor	0.0028	0.0027	0.0016
Schistosoma mansoni	hypothetical protein	0.0028	0.0027	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0148	0.0279
Brugia malayi	ribonucleotide reductase 2	0.0136	0.0382	0.0671
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0027	0.0048
Trichomonas vaginalis	teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative	0.003	0.0032	0.0043
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.0027	0.0016
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.1703	0.5536	1
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Brugia malayi	Dopamine receptor protein 2	0.0028	0.0027	0.0028
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0051	0.0104	0.0188
Schistosoma mansoni	myosin xvIII	0.0028	0.0027	0.0028
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0027	0.0028
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0128	0.0357	0.0706
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0074	0.0177	0.0166
Mycobacterium leprae	conserved hypothetical protein	0.0195	0.0576	0.1156
Trypanosoma brucei	proteasome beta 6 subunit	0.0051	0.0104	0.0032
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0136	0.0382	0.0671
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit beta	0.0046	0.0087	0.0152
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0074	0.0177	0.0166
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0062	0.0139	0.0128
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0051	0.0104	0.0168
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0128	0.0357	0.0706
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.0177	0.034
Echinococcus granulosus	caspase 2	0.0057	0.0123	0.0112
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0027	0.0016
Brugia malayi	proteasome subunit beta type 1	0.0051	0.0104	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0012	0.0002
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.0027	0.0028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Brugia malayi	Latrophilin receptor protein 2	0.0062	0.0139	0.0231
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.005	0.01	0.0161
Schistosoma mansoni	histamine h1 receptor	0.0028	0.0027	0.0028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Echinococcus multilocularis	serotonin receptor	0.0028	0.0027	0.0016
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0136	0.0382	0.0542
Echinococcus granulosus	orexin receptor type 2	0.0028	0.0027	0.0016
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0042	0.0063
Echinococcus multilocularis	fibrillin 1	0.003	0.0032	0.0021
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0051	0.0104	0.0166
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.0027	0.0016
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0128	0.0357	0.0706
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.0027	0.0016
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0128	0.0357	0.0706
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0027	0.0028
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	0.1703	0.5536	1
Echinococcus granulosus	GPCR family 2	0.0062	0.0139	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0027	0.0016
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0128	0.0357	0.0706
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0177	0.034
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.0027	0.0028
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.1508	0.4894	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0027	0.0028
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0128	0.0357	0.0706
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0042	0.0063
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0375	0.0677
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.0027	0.0048
Chlamydia trachomatis	transcriptional repressor NrdR	0.0195	0.0576	0.0378
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0196	0.0578	0.1026
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0128	0.0357	0.0706
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.0177	0.034
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0027	0.0016
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0027	0.0016
Schistosoma mansoni	opsin-like receptor	0.0028	0.0027	0.0028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Brugia malayi	Serotonin receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.0027	0.0048
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0027	0.0016
Echinococcus multilocularis	caspase 2	0.0057	0.0123	0.0112
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.0027	0.0028
Echinococcus granulosus	somatostatin receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0393	0.071
Schistosoma mansoni	hypothetical protein	0.0062	0.0139	0.0231
Brugia malayi	hypothetical protein	0.004	0.0067	0.0101
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.1703	0.5536	1
Schistosoma mansoni	cell polarity protein	0.0024	0.0013	0.0004
Mycobacterium ulcerans	transcriptional regulator NrdR	0.0195	0.0576	0.1156
Brugia malayi	Dopamine receptor protein 1	0.0028	0.0027	0.0028
Schistosoma mansoni	hypothetical protein	0.0062	0.0139	0.0231
Brugia malayi	neuropeptide F receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0027	0.0048
Echinococcus granulosus	serotonin receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Toxoplasma gondii	hypothetical protein	0.0023	0.0012	0.0002
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.01	0.0182
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.1703	0.5536	1
Plasmodium vivax	ribonucleoside-diphosphate reductase small chain, putative	0.0136	0.0382	0.0669
Schistosoma mansoni	caspase-7 (C14 family)	0.0057	0.0123	0.0203
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.1703	0.5536	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0027	0.0028
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0136	0.0382	0.0542
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.0027	0.0016
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0051	0.0104	0.019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0027	0.0028
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.0177	0.0167
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0128	0.0357	0.0706
Brugia malayi	Cell death protein 3 precursor	0.0057	0.0123	0.0203
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.0027	0.0016
Schistosoma mansoni	serine-type protease inhibitor	0.0437	0.1372	0.2464
Loa Loa (eye worm)	hypothetical protein	0.003	0.0032	0.0058
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.1508	0.4894	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.0027	0.0028
Brugia malayi	latrophilin 2 splice variant baaae	0.0134	0.0375	0.0658
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0128	0.0357	0.0706
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0128	0.0357	0.0706
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0128	0.0357	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.0027	0.0016
Brugia malayi	putative neuropeptide receptor	0.0028	0.0027	0.0028
Brugia malayi	Dopamine receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0196	0.0578	0.1044
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0123	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0042	0.0076
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.0177	0.0301
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0051	0.0104	0.0168
Schistosoma mansoni	hypothetical protein	0.0134	0.0375	0.0658
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0139	0.025
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0051	0.0104	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0062	0.0139	0.0231
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.0027	0.0028
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.0027	0.0028
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0074	0.0177	0.0301
Schistosoma mansoni	amine GPCR	0.0028	0.0027	0.0028
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.0027	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0128	0.0357	0.0706
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0051	0.0104	0.0168
Echinococcus multilocularis	integrin beta 2	0.0679	0.2169	0.216
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0136	0.0382	0.0671
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.3061	1	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0062	0.0139	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Brugia malayi	G-protein coupled receptor	0.0028	0.0027	0.0028
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0033	0.0042	0.0031
Loa Loa (eye worm)	rad51	0.0023	0.0011	0.002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0136	0.0382	0.0669
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.1703	0.5536	1
Echinococcus multilocularis	fibrillin 2	0.003	0.0032	0.0021
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein)	0.0136	0.0382	0.0757
Echinococcus granulosus	hypothetical protein	0.0028	0.0027	0.0016
Echinococcus granulosus	fmrfamide receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Toxoplasma gondii	ribonucleoside-diphosphate reductase small subunit	0.0136	0.0382	0.0671
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0027	0.0028
Brugia malayi	Melatonin receptor type 1A	0.0028	0.0027	0.0028
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0027	0.0016
Brugia malayi	Kelch motif family protein	0.0139	0.0393	0.0692
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0033	0.0042	0.0056
Echinococcus multilocularis	adam	0.003	0.0032	0.0021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0027	0.0028
Schistosoma mansoni	amine GPCR	0.0028	0.0027	0.0028
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0177	0.034
Echinococcus multilocularis	ribonucleoside diphosphate reductase subunit	0.0136	0.0382	0.0371
Brugia malayi	Guanylate kinase family protein	0.0026	0.0021	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0128	0.0357	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus granulosus	ribonucleoside diphosphate reductase subunit	0.0136	0.0382	0.0371
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0027	0.0016
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.0027	0.0028
Brugia malayi	EGF-like domain containing protein	0.003	0.0032	0.0038
Echinococcus multilocularis	serotonin receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0148	0.0279
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.0177	0.0301
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0027	0.0016
Trypanosoma cruzi	ribonucleoside-diphosphate reductase small chain, putative	0.0136	0.0382	0.0671
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Brugia malayi	GnHR receptor homolog	0.0028	0.0027	0.0028
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0027	0.0016
Echinococcus granulosus	integrin beta 2	0.0679	0.2169	0.216
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.0027	0.0016
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.0027	0.0028
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0027	0.0028
Echinococcus multilocularis	disks large 3	0.0024	0.0013	0.0002
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.1703	0.5536	1
Brugia malayi	EGF-like domain containing protein	0.003	0.0032	0.0038
Mycobacterium tuberculosis	Probable transcriptional regulatory protein NrdR	0.0195	0.0576	0.1156
Echinococcus multilocularis	sex peptide receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0033	0.0042	0.0056
Schistosoma mansoni	opsin-like receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Leishmania major	ribonucleoside-diphosphate reductase small chain, putative	0.0136	0.0382	0.0671
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0051	0.0104	0.0093
Schistosoma mansoni	hypothetical protein	0.004	0.0067	0.0101
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0027	0.0028
Onchocerca volvulus		0.004	0.0067	0.4144
Loa Loa (eye worm)	hypothetical protein	0.003	0.0032	0.0058
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Brugia malayi	G-protein coupled receptor	0.0028	0.0027	0.0028
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0051	0.0104	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0027	0.0028
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0128	0.0357	0.0706
Schistosoma mansoni	adenoreceptor	0.0028	0.0027	0.0028
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.0027	0.0016
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0027	0.0016
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.0027	0.0016
Toxoplasma gondii	GAF domain-containing protein	0.0023	0.0012	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Loa Loa (eye worm)	lethal(1)discs large-1 tumor suppressor	0.0022	0.0009	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.0027	0.0028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.0027	0.0016
Plasmodium vivax	ribonucleotide reductase small subunit, putative	0.0046	0.0087	0.0134
Brugia malayi	EGF-like domain containing protein	0.003	0.0032	0.0038
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.1508	0.4894	1
Brugia malayi	RE15519p	0.0028	0.0027	0.0028
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0027	0.0028
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.0027	0.0016
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.0027	0.0028
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0027	0.0016
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0027	0.0016
Plasmodium falciparum	ribonucleoside-diphosphate reductase small chain, putative	0.0046	0.0087	0.0134
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0027	0.0016
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0051	0.0104	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0027	0.0016
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0148	0.0279
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0027	0.0048
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Trichomonas vaginalis	hypothetical protein	0.003	0.0032	0.0043
Brugia malayi	AKH receptor	0.0028	0.0027	0.0028
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0033	0.0042	0.0031
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.0027	0.0048
Mycobacterium tuberculosis	Probable oxidoreductase	0.0125	0.0345	0.0682
Brugia malayi	Serotonin receptor	0.0028	0.0027	0.0028
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0027	0.0028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.003	0.0032	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain)	0.0136	0.0382	0.0757
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0177	0.034
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.01	0.0182
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.1703	0.5536	0.5531
Brugia malayi	larval opioid receptor	0.0028	0.0027	0.0028
Schistosoma mansoni	hypothetical protein	0.0028	0.0027	0.0028
Loa Loa (eye worm)	integrin beta-2	0.0917	0.295	0.533
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0196	0.0578	0.1044
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0128	0.0357	0.0706
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.0027	0.0048
Brugia malayi	G protein-coupled receptor	0.0028	0.0027	0.0028
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.1703	0.5536	1
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.0027	0.0028
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0027	0.0028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0027	0.0028
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0027	0.0016
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0033	0.0042	0.0056
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.0027	0.0016
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.0027	0.0028
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0128	0.0357	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Schistosoma mansoni	amine GPCR	0.0028	0.0027	0.0028
Brugia malayi	EGF-like domain containing protein	0.003	0.0032	0.0038
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0128	0.0357	0.0706
Brugia malayi	hypothetical protein	0.0139	0.0393	0.0692
Mycobacterium ulcerans	oxidoreductase	0.0125	0.0345	0.0682
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.0177	0.0167
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0177	0.034
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain	0.0136	0.0382	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0062	0.0139	0.0128
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.003	0.0032	0.0058
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0027	0.0028
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.0027	0.0016
Schistosoma mansoni	amine GPCR	0.0028	0.0027	0.0028
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0027	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0027	0.0028
Onchocerca volvulus		0.003	0.0032	0.0571
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0027	0.0028
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0128	0.0357	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0027	0.0016
Schistosoma mansoni	serine-type protease inhibitor	0.0437	0.1372	0.2464
Schistosoma mansoni	hypothetical protein	0.0028	0.0027	0.0028
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0196	0.0578	0.1026
Echinococcus granulosus	disks large 3	0.0024	0.0013	0.0002
Trypanosoma brucei	RNA helicase, putative	0.0104	0.0279	0.0353
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.0027	0.0028
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.1508	0.4894	1
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (BETA CHAIN) NRDF (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R2F PROTEIN)	0.0046	0.0087	0.0152
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Echinococcus granulosus	fibrillin 2	0.003	0.0032	0.0021
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Schistosoma mansoni	hypothetical protein	0.0062	0.0139	0.0231
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0139	0.0393	0.071
Brugia malayi	hypothetical protein	0.0028	0.0027	0.0028
Echinococcus multilocularis	GPCR, family 2	0.0062	0.0139	0.0128
Brugia malayi	ORL1-like opioid receptor	0.0028	0.0027	0.0028
Echinococcus granulosus	adam	0.003	0.0032	0.0021
Echinococcus granulosus	fibrillin 1	0.003	0.0032	0.0021
Echinococcus multilocularis	apoptotic protease activating factor 1	0.004	0.0067	0.0056
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.0027	0.0048
Onchocerca volvulus	Cell death protein 3 homolog	0.0057	0.0123	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Toxoplasma gondii	hypothetical protein	0.003	0.0032	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.0177	0.034
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Toxoplasma gondii	hypothetical protein	0.0065	0.0148	0.0247
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0128	0.0357	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0051	0.0104	0.0166
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.0027	0.0016
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0033	0.0042	0.0063
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0027	0.0016
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0128	0.0357	0.0706
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Schistosoma mansoni	amine GPCR	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0012	0.0022
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.0027	0.0016
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.1703	0.5536	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.0177	0.034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Brugia malayi	Integrin beta pat-3 precursor	0.0917	0.295	0.532
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0128	0.0357	0.0706
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.0027	0.0028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0027	0.0028
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0463	0.1457	0.2616
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0027	0.0016
Schistosoma mansoni	integrin beta subunit	0.054	0.1711	0.3076
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.1508	0.4894	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0062	0.0139	0.025
Trypanosoma brucei	ribonucleoside-diphosphate reductase small chain, putative	0.0136	0.0382	0.0542
Echinococcus multilocularis	protein jagged 2	0.003	0.0032	0.0021
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0128	0.0357	0.0706
Schistosoma mansoni	hypothetical protein	0.0062	0.0139	0.0231
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0027	0.0028
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.0027	0.0028
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0074	0.0177	0.034
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Toxoplasma gondii	hypothetical protein	0.0023	0.0012	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Schistosoma mansoni	hypothetical protein	0.0028	0.0027	0.0028
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.0027	0.0048
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0027	0.0016
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.004	0.0067	0.0121
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0027	0.0016
Brugia malayi	sulfakinin receptor protein	0.0028	0.0027	0.0028
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0128	0.0357	0.0706
Giardia lamblia	Proteasome subunit beta type 1	0.0051	0.0104	1
Brugia malayi	neuropeptide F receptor	0.0028	0.0027	0.0028
Schistosoma mansoni	opsin-like receptor	0.0028	0.0027	0.0028
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.0177	0.0301
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.1703	0.5536	1
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0027	0.0016
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Schistosoma mansoni	ribonucleoside-diphosphate reductase small chain	0.0136	0.0382	0.0671
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0128	0.0357	0.0706
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0027	0.0016
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.1703	0.5536	0.5531
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.0177	0.034
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0051	0.0104	0.0168
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.0027	0.0016
Schistosoma mansoni	hypothetical protein	0.0104	0.0279	0.0484
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0128	0.0357	0.0706
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.1703	0.5536	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0177	0.034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0027	0.0028
Echinococcus granulosus	apoptotic protease activating factor 1	0.004	0.0067	0.0056
Echinococcus multilocularis	somatostatin receptor	0.0028	0.0027	0.0016
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0027	0.0016
Echinococcus granulosus	allatostatin A receptor	0.0028	0.0027	0.0016
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.0177	0.034
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0027	0.0028
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0062	0.0139	0.0128
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.0542	0.1718	0.3494
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.0027	0.0028
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0027	0.0048
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.0177	0.034
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0128	0.0357	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0048
Loa Loa (eye worm)	ribonucleotide reductase M2 B	0.0136	0.0382	0.069
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0027	0.0016

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.072 uM	Inhibitory activity against phosphodiesterase 5 from human platelets	ChEMBL.	7658441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL542707

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1037867