pI: 6.954 |
Length (AA): 258 |
MW (Da): 28706 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127834)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G60820 | proteasome subunit beta type-1 |
Babesia bovis | BBOV_II002710 | proteasome A-type and B-type family protein |
Brugia malayi | Bm1_14125 | proteasome subunit beta type 1 |
Candida albicans | CaO19.2755 | proteasome subunit |
Candida albicans | CaO19.10269 | proteasome subunit |
Caenorhabditis elegans | CELE_C02F5.9 | Protein PBS-6 |
Cryptosporidium hominis | Chro.10279 | proteasome subunit beta type 1 (20S proteasome alpha subunit F) (20S proteasome subunit beta-6) |
Cryptosporidium parvum | cgd1_2490 | proteasome subunit beta type 1, putative |
Dictyostelium discoideum | DDB_G0272969 | 20S proteasome subunit beta-1 |
Drosophila melanogaster | Dmel_CG4097 | Proteasome beta6 subunit |
Echinococcus granulosus | EgrG_000252500 | proteasome prosome macropain subunit beta |
Entamoeba histolytica | EHI_174670 | proteasome subunit beta type 1, putative |
Echinococcus multilocularis | EmuJ_000252500 | proteasome (prosome, macropain) subunit, beta |
Giardia lamblia | GL50803_13127 | Proteasome subunit beta type 1 |
Homo sapiens | ENSG00000008018 | proteasome (prosome, macropain) subunit, beta type, 1 |
Leishmania braziliensis | LbrM.06.0120 | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative |
Leishmania donovani | LdBPK_060140.1 | proteasome beta 6 subunit, putative |
Leishmania infantum | LinJ.06.0140 | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative |
Leishmania major | LmjF.06.0140 | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative |
Leishmania mexicana | LmxM.06.0140 | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative |
Loa Loa (eye worm) | LOAG_00616 | proteasome subunit beta type 1 |
Mus musculus | ENSMUSG00000014769 | proteasome (prosome, macropain) subunit, beta type 1 |
Neospora caninum | NCLIV_042370 | hypothetical protein |
Oryza sativa | 4347507 | Os09g0505600 |
Oryza sativa | 4346117 | Os08g0529100 |
Plasmodium berghei | PBANKA_1233100 | proteasome subunit beta type-1, putative |
Plasmodium falciparum | PF3D7_0518300 | proteasome subunit beta type-1, putative |
Plasmodium knowlesi | PKNH_1014900 | proteasome subunit beta type-1, putative |
Plasmodium vivax | PVX_080330 | proteasome subunit beta type-1, putative |
Plasmodium yoelii | PY02685 | proteasome subunit beta type 1-related |
Saccharomyces cerevisiae | YBL041W | proteasome core particle subunit beta 6 |
Schistosoma japonicum | Sjp_0090370 | ko:K02732 20S proteasome subunit beta 6, putative |
Schistosoma mansoni | Smp_025800 | proteasome subunit beta 1 (T01 family) |
Schmidtea mediterranea | mk4.000144.04 | Proteasome subunit beta type-1 |
Trypanosoma brucei gambiense | Tbg972.7.5470 | proteasome beta 6 subunit,20S proteasome beta 6 subunit, putative |
Trypanosoma brucei | Tb11.v5.0162 | proteasome beta 6 subunit |
Trypanosoma congolense | TcIL3000_7_3960 | proteasome beta 6 subunit |
Trypanosoma cruzi | TcCLB.507521.50 | proteasome beta 6 subunit, putative |
Trypanosoma cruzi | TcCLB.508577.160 | proteasome beta 6 subunit, putative |
Toxoplasma gondii | TGME49_290005 | proteasome subunit beta type 1, putative |
Theileria parva | TP04_0315 | proteasome beat subunit, putative |
Trichomonas vaginalis | TVAG_152400 | Family T1, proteasome beta subunit, threonine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.4790 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.4790 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.4790 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.7.4790 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C02F5.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C02F5.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C02F5.9 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C02F5.9 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C02F5.9 | Caenorhabditis elegans | sterile | wormbase |
YBL041W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1233100 | Plasmodium berghei | Essential | plasmo |
TGME49_290005 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Saccharomyces cerevisiae | proteasome core particle subunit beta 6 | Compounds | References |
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 1 | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
Tb11.v5.0162 | purified protein | BRENDA | A protein with this EC number or name or sequence has been purified from Trypanosoma brucei ( 2 ) |
35 literature references were collected for this gene.