Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0556 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0423 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0556 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0081 | 0.007 | 0.007 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0081 | 0.007 | 0.007 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0423 | 0.7224 | 0.7224 |
Mycobacterium ulcerans | proteasome PrcB | 0.0556 | 1 | 1 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0163 | 0.1787 | 0.6412 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0556 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0211 | 0.2787 | 0.2787 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.1787 | 0.1787 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0423 | 0.7224 | 0.7224 |
Toxoplasma gondii | prolyl endopeptidase | 0.0163 | 0.1787 | 0.1787 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0423 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0556 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0556 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0163 | 0.1787 | 0.1787 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0163 | 0.1787 | 0.1787 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0081 | 0.007 | 0.007 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0556 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0423 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain | 0.0556 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0081 | 0.007 | 0.007 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0423 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0423 | 0.7224 | 0.7224 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0081 | 0.007 | 0.007 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0078 | 0 | 0.5 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0423 | 0.7224 | 0.7224 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0211 | 0.2787 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0211 | 0.2787 | 0.2787 |
Echinococcus granulosus | prolyl endopeptidase | 0.0163 | 0.1787 | 0.1787 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0423 | 0.7224 | 0.7224 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0163 | 0.1787 | 0.1787 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0081 | 0.007 | 0.007 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0423 | 0.7224 | 0.7224 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0556 | 1 | 1 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0556 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0211 | 0.2787 | 0.2787 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0556 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0081 | 0.007 | 0.007 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0163 | 0.1787 | 0.1787 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0163 | 0.1787 | 0.1787 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0556 | 1 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0163 | 0.1787 | 0.1787 |
Brugia malayi | proteasome subunit beta type 1 | 0.0423 | 0.7224 | 0.7224 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0556 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0081 | 0.007 | 0.007 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0081 | 0.007 | 0.007 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0211 | 0.2787 | 0.2787 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0556 | 1 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0211 | 0.2787 | 0.2787 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0081 | 0.007 | 0.007 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0423 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0556 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0423 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0556 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0163 | 0.1787 | 0.1787 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0556 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0132 | 0.1138 | 0.1138 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0423 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0423 | 0.7224 | 0.7224 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.