Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0241 | 0.2778 | 0.2382 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0241 | 0.2778 | 0.2382 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0162 | 0.1628 | 0.1169 |
Plasmodium falciparum | proteasome subunit alpha type-2, putative | 0.0087 | 0.0519 | 0.0519 |
Plasmodium falciparum | proteasome subunit alpha type-1, putative | 0.0087 | 0.0519 | 0.0519 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0162 | 0.1628 | 0.1169 |
Plasmodium falciparum | ATP-dependent protease subunit ClpQ | 0.0087 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0703 | 0.0194 |
Echinococcus granulosus | proteasome prosome macropain | 0.0731 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0731 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0731 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0241 | 0.2778 | 0.2382 |
Plasmodium falciparum | proteasome subunit beta type-7, putative | 0.0087 | 0.0519 | 0.0519 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0162 | 0.1628 | 0.1169 |
Leishmania major | proteasome alpha 7 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0162 | 0.1628 | 0.1169 |
Onchocerca volvulus | Protein Malvolio homolog | 0.0102 | 0.0735 | 1 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0162 | 0.1628 | 0.1169 |
Plasmodium falciparum | proteasome subunit alpha type-3, putative | 0.0087 | 0.0519 | 0.0519 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0162 | 0.1628 | 0.1169 |
Leishmania major | proteasome alpha 1 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0162 | 0.1628 | 0.1169 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0087 | 0.0519 | 0.5 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0241 | 0.2778 | 0.2382 |
Leishmania major | hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B | 0.0087 | 0.0519 | 0.0519 |
Leishmania major | proteasome alpha 2 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Leishmania major | proteasome beta-1 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0731 | 1 | 1 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0102 | 0.0735 | 0.0228 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0102 | 0.0735 | 0.0228 |
Plasmodium falciparum | transporter, putative | 0.0102 | 0.0735 | 0.0735 |
Brugia malayi | Adhesion regulating molecule conserved region family protein | 0.01 | 0.0703 | 0.0194 |
Leishmania major | proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) | 0.0087 | 0.0519 | 0.0519 |
Echinococcus multilocularis | adhesion regulating molecule 1 | 0.01 | 0.0703 | 0.0194 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0102 | 0.0735 | 0.0228 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0162 | 0.1628 | 0.1169 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0731 | 1 | 1 |
Leishmania major | proteasome alpha 7 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.0087 | 0.0519 | 0.0362 |
Brugia malayi | NRAMP-like transporter K11G12.4 | 0.0102 | 0.0735 | 0.0228 |
Plasmodium falciparum | proteasome subunit beta type-6, putative | 0.0087 | 0.0519 | 0.0519 |
Plasmodium falciparum | proteasome subunit alpha type-6, putative | 0.0087 | 0.0519 | 0.0519 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0241 | 0.2778 | 0.2382 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0241 | 0.2778 | 0.2382 |
Plasmodium vivax | metal transporter, putative | 0.0102 | 0.0735 | 0.0228 |
Plasmodium falciparum | proteasome subunit beta type-3, putative | 0.0087 | 0.0519 | 0.0519 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0731 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0162 | 0.1628 | 0.1169 |
Plasmodium falciparum | proteasome subunit alpha type-7, putative | 0.0087 | 0.0519 | 0.0519 |
Leishmania major | proteasome beta 7 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0731 | 1 | 1 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Leishmania major | proteasome alpha 1 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0731 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0735 | 0.0228 |
Mycobacterium leprae | probable proteasome (alpha subunit) PrcA | 0.0087 | 0.0519 | 0.0362 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0731 | 1 | 1 |
Toxoplasma gondii | divalent metal transporter, putative | 0.0102 | 0.0735 | 0.0228 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0162 | 0.1628 | 0.1628 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0241 | 0.2778 | 0.2382 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0162 | 0.1628 | 0.1169 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0087 | 0.0519 | 0.0519 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0162 | 0.1628 | 0.1169 |
Echinococcus granulosus | divalent metal transporter DMT1B | 0.0102 | 0.0735 | 0.0228 |
Leishmania major | proteasome alpha 3 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0087 | 0.0519 | 0.0519 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0731 | 1 | 1 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0087 | 0.0519 | 0.0519 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0731 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0731 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0241 | 0.2778 | 0.2382 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0162 | 0.1628 | 0.1169 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0241 | 0.2778 | 0.2382 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0731 | 1 | 1 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0087 | 0.0519 | 0.0519 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0241 | 0.2778 | 0.2382 |
Toxoplasma gondii | adhesion regulating molecule region protein, putative | 0.01 | 0.0703 | 0.0194 |
Plasmodium falciparum | proteasome subunit alpha type-4, putative | 0.0087 | 0.0519 | 0.0519 |
Plasmodium falciparum | proteasome subunit beta type-4 | 0.0087 | 0.0519 | 0.0519 |
Onchocerca volvulus | Notchless protein homolog | 0.0087 | 0.0519 | 0.6194 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0241 | 0.2778 | 0.2382 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0241 | 0.2778 | 0.2382 |
Echinococcus multilocularis | divalent metal transporter DMT1B | 0.0102 | 0.0735 | 0.0228 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0731 | 1 | 1 |
Leishmania major | proteasome beta 3 subunit, putative | 0.0087 | 0.0519 | 0.0519 |
Brugia malayi | proteasome subunit beta type 2 | 0.0162 | 0.1628 | 0.1169 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0162 | 0.1628 | 0.1169 |
Echinococcus granulosus | adhesion regulating molecule 1 | 0.01 | 0.0703 | 0.0194 |
Mycobacterium ulcerans | proteasome PrcB | 0.0731 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0241 | 0.2778 | 0.2382 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0087 | 0.0519 | 0.0519 |
Plasmodium falciparum | proteasome subunit alpha type-5, putative | 0.0087 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0731 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0241 | 0.2778 | 0.2778 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0087 | 0.0519 | 0.0519 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0241 | 0.2778 | 0.2778 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0731 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0162 | 0.1628 | 0.1169 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0162 | 0.1628 | 0.1628 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0735 | 0.0228 |
Schistosoma mansoni | adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) | 0.01 | 0.0703 | 0.0194 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 50000 nM | Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]-nicotine as radioligand | ChEMBL. | 14611837 |
Ki (binding) | > 50000 nM | Binding affinity towards alpha3-beta4 subtype of neuronal nicotinic acetylcholine receptor (nAChR) using [3H]-epibatidine as radioligand | ChEMBL. | 14611837 |
Ki (binding) | > 50000 nM | Binding affinity towards Nicotinic acetylcholine receptor alpha7 using [3H]-MLA as radioligand | ChEMBL. | 14611837 |
Ki (binding) | > 50000 nM | Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]-nicotine as radioligand | ChEMBL. | 14611837 |
Ki (binding) | > 50000 nM | Binding affinity towards alpha3-beta4 subtype of neuronal nicotinic acetylcholine receptor (nAChR) using [3H]-epibatidine as radioligand | ChEMBL. | 14611837 |
Ki (binding) | > 50000 nM | Binding affinity towards Nicotinic acetylcholine receptor alpha7 using [3H]-MLA as radioligand | ChEMBL. | 14611837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.