Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0239 | 0.3546 | 0.3546 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0497 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0497 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0239 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0386 | 0.7224 | 0.7224 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0497 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0239 | 0.3546 | 0.3546 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0386 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0386 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0497 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0098 | 0 | 0.5 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0239 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0386 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0497 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0497 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0386 | 0.7224 | 0.7224 |
Mycobacterium ulcerans | proteasome PrcB | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0386 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0239 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0239 | 0.3546 | 0.3546 |
Onchocerca volvulus | Notchless protein homolog | 0.0098 | 0 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0239 | 0.3546 | 0.3546 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0497 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0386 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0386 | 0.7224 | 0.7224 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0497 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0386 | 0.7224 | 0.7224 |
Echinococcus granulosus | proteasome prosome macropain | 0.0497 | 1 | 1 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0239 | 0.3546 | 0.3546 |
Brugia malayi | proteasome subunit beta type 1 | 0.0386 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0239 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0239 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0239 | 0.3546 | 0.3546 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0386 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0239 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0497 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0239 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0497 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0386 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0497 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0497 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0386 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0239 | 0.3546 | 0.3546 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0239 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0497 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0497 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0239 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0386 | 0.7224 | 0.7224 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0386 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0239 | 0.3546 | 0.3546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug metabolism (ADMET) | = 7 micromol/min | Drug metabolism assessed as human recombinant NQO1-mediated cytochrome C reduction per mg of protein by spectrophotometric analysis | ChEMBL. | 23574193 |
IC50 (functional) | = 0.64 uM | Cytotoxicity against human MDA-MB-468 cells expressing NQO1 incubated for 2 hrs measured after 3 to 5 days by MTT assay | ChEMBL. | 23574193 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23574193 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.