Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0349 | 0.3391 | 0.5699 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.045 | 0.4755 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0216 | 0.1584 | 0.3331 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.045 | 0.4755 | 1 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0349 | 0.3391 | 0.7131 |
Echinococcus multilocularis | Ankyrin | 0.01 | 0.0007 | 0.0007 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.045 | 0.4755 | 0.4755 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0216 | 0.1584 | 0.3331 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0835 | 1 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0349 | 0.3391 | 0.5699 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0349 | 0.3391 | 0.5699 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.045 | 0.4755 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.045 | 0.4755 | 0.5 |
Echinococcus granulosus | proteasome prosome macropain | 0.045 | 0.4755 | 0.4755 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0349 | 0.3391 | 0.3391 |
Brugia malayi | proteasome subunit beta type 1 | 0.0349 | 0.3391 | 0.7131 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.045 | 0.4755 | 1 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0349 | 0.3391 | 0.5699 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.01 | 0.0007 | 0.0015 |
Mycobacterium ulcerans | proteasome PrcB | 0.045 | 0.4755 | 0.5 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0349 | 0.3391 | 0.5699 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.045 | 0.4755 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0216 | 0.1584 | 0.3331 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.045 | 0.4755 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.045 | 0.4755 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0349 | 0.3391 | 0.5699 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.045 | 0.4755 | 1 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.045 | 0.4755 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0216 | 0.1584 | 0.1584 |
Leishmania major | proteasome beta 5 subunit, putative | 0.045 | 0.4755 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.045 | 0.4755 | 0.5 |
Echinococcus granulosus | Ankyrin | 0.01 | 0.0007 | 0.0007 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0349 | 0.3391 | 0.3391 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0349 | 0.3391 | 0.5699 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.045 | 0.4755 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0349 | 0.3391 | 0.5699 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.045 | 0.4755 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.045 | 0.4755 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0349 | 0.3391 | 0.7127 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0349 | 0.3391 | 0.5699 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0216 | 0.1584 | 0.1584 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0216 | 0.1584 | 0.3321 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0349 | 0.3391 | 0.5699 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | NB 0 uM | Minimum concentration of the compound required for the complete blockage of virus induced cell division ; NB means no blockage of cell fusion at the highest concentration where there is cytotoxicity at 100 microM | ChEMBL. | 6219223 |
Ki (binding) | > 100 uM | Inhibition constant against bovine trypsin | ChEMBL. | 6219223 |
Ki (binding) | > 100 uM | Inhibition constant against bovine trypsin | ChEMBL. | 6219223 |
Ki (binding) | = 176 uM | Inhibition constant against bovine thrombin | ChEMBL. | 6219223 |
Ki (binding) | = 176 uM | Inhibition constant against bovine thrombin | ChEMBL. | 6219223 |
Ki (binding) | > 200 uM | Inhibition constant against human plasminogen | ChEMBL. | 6219223 |
Ki (binding) | > 200 uM | Inhibition constant against human plasminogen | ChEMBL. | 6219223 |
Ki (binding) | = 267 uM | Inhibition constant against Urokinase | ChEMBL. | 6219223 |
Ki (binding) | = 267 uM | Inhibition constant against Urokinase | ChEMBL. | 6219223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.