Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Ovis aries | Cyclooxygenase-1 | Starlite/ChEMBL | References |
Ovis aries | Cyclooxygenase-2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0062 | 0.5268 | 0.5699 |
Schistosoma mansoni | peroxidasin | 0.0095 | 1 | 1 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0039 | 0.1859 | 0.1859 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.008 | 0.7842 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0062 | 0.5268 | 0.5268 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.008 | 0.7842 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0095 | 1 | 1 | |
Leishmania major | proteasome beta 5 subunit, putative | 0.008 | 0.7842 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.008 | 0.7842 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0095 | 1 | 1 | |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0039 | 0.1859 | 0.1859 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.008 | 0.7842 | 0.7842 |
Brugia malayi | Peroxidasin | 0.0095 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0039 | 0.1859 | 0.1859 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0062 | 0.5268 | 0.5699 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.008 | 0.7842 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0062 | 0.5268 | 0.5268 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.008 | 0.7842 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0039 | 0.1859 | 0.1859 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 1 | 1 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.008 | 0.7842 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.008 | 0.7842 | 1 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0062 | 0.5268 | 0.5699 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0062 | 0.5268 | 0.5268 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0062 | 0.5268 | 0.5268 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.008 | 0.7842 | 0.7842 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.008 | 0.7842 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0062 | 0.5268 | 0.5699 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0039 | 0.1859 | 0.1859 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Onchocerca volvulus | 0.0095 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.008 | 0.7842 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.008 | 0.7842 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0039 | 0.1859 | 0.1859 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.008 | 0.7842 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.008 | 0.7842 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0062 | 0.5268 | 0.5699 |
Echinococcus granulosus | proteasome prosome macropain | 0.008 | 0.7842 | 0.7842 |
Brugia malayi | Blistered cuticle protein 3 | 0.0095 | 1 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.008 | 0.7842 | 0.7842 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0062 | 0.5268 | 0.5699 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0095 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0095 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0062 | 0.5268 | 0.5699 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0062 | 0.5268 | 0.5699 |
Onchocerca volvulus | Peroxidase homolog | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0095 | 1 | 1 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0062 | 0.5268 | 0.5699 |
Onchocerca volvulus | Dual oxidase homolog | 0.0095 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0095 | 1 | 1 |
Echinococcus granulosus | peroxidasin | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0062 | 0.5268 | 0.5268 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0062 | 0.5268 | 0.5699 |
Echinococcus multilocularis | peroxidasin | 0.0095 | 1 | 1 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.008 | 0.7842 | 0.7842 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0095 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.88 uM | Inhibition of ovine COX1 by enzyme immunoassay | ChEMBL. | 18096394 |
IC50 (binding) | = 0.88 uM | Inhibition of ovine COX1 by enzyme immunoassay | ChEMBL. | 18096394 |
IC50 (binding) | = 3.6 uM | Inhibition of ovine COX2 by enzyme immunoassay | ChEMBL. | 18096394 |
IC50 (binding) | = 3.6 uM | Inhibition of ovine COX2 by enzyme immunoassay | ChEMBL. | 18096394 |
Ratio IC50 (binding) | = 0.24 | Selectivity index, ratio of IC50 for ovine COX1 to IC50 for ovine COX2 | ChEMBL. | 18096394 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.