Detailed information for compound 1906009

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.421 | Formula: C19H17N3O4S
  • H donors: 2 H acceptors: 3 LogP: 2.65 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N[C@H](C(=O)Nc1ccc(cc1)c1nsc(=O)o1)Cc1ccccc1
  • InChi: 1S/C19H17N3O4S/c1-12(23)20-16(11-13-5-3-2-4-6-13)17(24)21-15-9-7-14(8-10-15)18-22-27-19(25)26-18/h2-10,16H,11H2,1H3,(H,20,23)(H,21,24)/t16-/m0/s1
  • InChiKey: UTMWNVYSIIRNHA-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens proteasome (prosome, macropain) subunit, beta type, 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans proteasome PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania mexicana proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium vivax proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium leprae proteasome (beta subunit) PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Toxoplasma gondii proteasome subunit beta type, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Giardia lamblia Proteasome subunit beta type 5 precursor Get druggable targets OG5_127100 All targets in OG5_127100
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative Get druggable targets OG5_127100 All targets in OG5_127100
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania infantum proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium berghei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Loa Loa (eye worm) proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium yoelii proteosome PSMB5/8 protein Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma japonicum ko:K02737 20S proteasome subunit beta 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Babesia bovis proteasome epsilon subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus granulosus proteasome prosome macropain Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma congolense proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium knowlesi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Brugia malayi Proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei gambiense proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium parvum Pre2p/proteasome subunit beta type 5; NTN hydrolase fold Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Theileria parva proteasome subunit beta type 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania braziliensis proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Neospora caninum Family T1, proteasome beta subunit, threonine peptidase, related Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus multilocularis proteasome (prosome, macropain) Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium falciparum proteasome subunit beta type-5 Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania major proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania donovani proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii proteasome subunit beta type 1, putative proteasome (prosome, macropain) subunit, beta type, 8 272 aa 251 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0039 0.0498 0.0731
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.0042 0.058 0.085
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0036 0.0435 0.0639
Leishmania major proteasome beta 2 subunit, putative 0.0134 0.3165 0.4641
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0106 0.2377 0.3486
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0319 0.0468
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0023 0.0053 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0025
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0142 0.3384 0.4963
Plasmodium falciparum 26S protease regulatory subunit 4, putative 0.0021 0.0017 0.0025
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.014 0.3336 0.4892
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0032 0.0319 0.0468
Echinococcus granulosus subfamily T1A non peptidase ue 0.0153 0.3674 0.3674
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0319 0.0319
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0141 0.3349 0.4911
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0052 0.0879 0.1289
Toxoplasma gondii hypothetical protein 0.0028 0.0208 0.0304
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Loa Loa (eye worm) 26S protease regulatory subunit 8 0.0021 0.0000046814 0.0000068654
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0039 0.0498 0.0731
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0141 0.3349 0.4911
Echinococcus multilocularis adhesion regulating molecule 1 0.01 0.222 0.222
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0035 0.0399 0.0585
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0032 0.0314 0.0314
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0265 0.6819 1
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0132 0.3115 0.3115
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.014 0.3336 0.4892
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0134 0.3165 0.4641
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0022 0.0034 0.005
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0106 0.2377 0.3486
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0319 0.0468
Giardia lamblia 26S proteasome ATPase subunit S4, putative 0.0021 0.0017 0.0025
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0265 0.6819 1
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0017 0.0025
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0399 0.0399
Toxoplasma gondii PCI domain-containing protein 0.0032 0.0314 0.0461
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0039 0.0498 0.0731
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0134 0.3165 0.4641
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0193 0.4797 0.7035
Entamoeba histolytica proteasome regulatory subunit, putative 0.0042 0.058 0.085
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0132 0.3115 0.4568
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0031 0.0273 0.0401
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0146 0.3484 0.5109
Loa Loa (eye worm) PAS-3 protein 0.0123 0.2854 0.4185
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0228 0.5786 0.5786
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0042 0.058 0.058
Brugia malayi Proteasome A-type and B-type family protein 0.0132 0.3115 0.3115
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0395 0.0395
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0134 0.3165 0.4641
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0134 0.3165 0.3164
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0032 0.0319 0.0319
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0023 0.0051 0.0074
Loa Loa (eye worm) proteasome 26S subunit 0.0021 0.0000046814 0.0000068654
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0164 0.3981 0.3981
Loa Loa (eye worm) proteasome Regulatory Particle 0.0035 0.0395 0.058
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.014 0.3336 0.3336
Brugia malayi proteasome subunit beta type 1 0.0164 0.3981 0.3981
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0319 0.0468
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0142 0.3384 0.4963
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0035 0.0395 0.058
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.0042 0.058 0.058
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0032 0.0319 0.0468
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0153 0.3674 0.3674
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0128 0.3001 0.4402
Echinococcus multilocularis 26S proteasome regulatory subunit T3 0.0021 0.0017 0.0017
Brugia malayi 26S proteasome subunit P45 family protein 0.0021 0.0017 0.0017
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0023 0.0051 0.0051
Trypanosoma brucei proteasome beta 7 subunit 0.0132 0.3115 0.4568
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0134 0.3165 0.3164
Leishmania major proteasome alpha 7 subunit, putative 0.0193 0.4797 0.7035
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0032 0.0314 0.0461
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0031 0.0289 0.0423
Toxoplasma gondii PCI domain-containing protein 0.0042 0.058 0.085
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0164 0.3981 0.3981
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0032 0.0314 0.0461
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0132 0.3115 0.4568
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0128 0.3001 0.4402
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0134 0.3165 0.4641
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0273 0.0401
Onchocerca volvulus 0.0021 0.0017 0.005
Loa Loa (eye worm) proteasome subunit beta type 1 0.0164 0.3981 0.5839
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0128 0.3001 0.4402
Trypanosoma brucei proteasome alpha 7 subunit 0.0142 0.3384 0.4963
Toxoplasma gondii proteasome subunit alpha type, putative 0.0087 0.184 0.2699
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0164 0.3981 0.5839
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0141 0.3349 0.4911
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0141 0.3349 0.4911
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.0042 0.058 0.085
Brugia malayi proteasome subunit alpha type 1 0.014 0.3321 0.3321
Loa Loa (eye worm) proteasome subunit alpha type 1 0.014 0.3321 0.4871
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.014 0.3321 0.4871
Onchocerca volvulus Notchless protein homolog 0.0142 0.3384 1
Trypanosoma cruzi proteasome regulatory ATPase subunit 3, putative 0.0021 0.0017 0.0025
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0395 0.058
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.014 0.3321 0.4871
Plasmodium vivax proteasome subunit beta type-7, putative 0.0128 0.3001 0.4402
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0032 0.0319 0.0319
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0141 0.3349 0.4911
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0035 0.0399 0.0585
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.0042 0.058 0.085
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0154 0.3702 0.5429
Loa Loa (eye worm) PCI domain-containing protein 0.0035 0.0399 0.0585
Toxoplasma gondii proteasome beta subunit 0.0134 0.3165 0.4641
Trypanosoma brucei proteasome beta 6 subunit 0.0164 0.3981 0.5839
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0132 0.3115 0.4568
Echinococcus granulosus proteasome subunit alpha type 2 0.0146 0.3484 0.3484
Plasmodium vivax proteasome subunit beta type-5, putative 0.0265 0.6819 1
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0164 0.3981 0.5839
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0128 0.3001 0.4402
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0039 0.0498 0.0731
Brugia malayi Ubiquitin interaction motif family protein 0.0023 0.0051 0.0051
Entamoeba histolytica proteasome regulatory subunit, putative 0.0031 0.0273 0.0401
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.014 0.3321 0.4871
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0036 0.0435 0.0639
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0154 0.3702 0.3702
Echinococcus multilocularis proteasome subunit beta type 7 0.0379 1 1
Schistosoma mansoni hypothetical protein 0.0228 0.5786 0.5786
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.014 0.3336 0.4892
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0153 0.3674 0.5387
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0134 0.3165 0.4641
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0106 0.2377 0.3486
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0164 0.3981 0.5839
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0032 0.0314 0.0461
Giardia lamblia 20S proteasome alpha subunit 2 0.0146 0.3484 0.5109
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0395 0.058
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.014 0.3321 0.3321
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0164 0.3981 0.5839
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0134 0.3165 0.4641
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0379 1 1
Echinococcus multilocularis proteasome (prosome, macropain) 0.0265 0.6819 0.6819
Echinococcus granulosus proteasome subunit beta t family 0.0134 0.3165 0.3164
Echinococcus granulosus 20S proteasome subunit alpha 6 0.014 0.3321 0.3321
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0031 0.0273 0.0273
Plasmodium falciparum proteasome subunit beta type-4 0.0132 0.3115 0.4568
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0193 0.4797 0.7035
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0032 0.0314 0.0314
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0106 0.2377 0.3486
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0022 0.0034 0.005
Plasmodium vivax 26S protease regulatory subunit 4, putative 0.0021 0.0017 0.0025
Giardia lamblia 26S protease regulatory subunit 6A 0.0023 0.0053 0.0077
Giardia lamblia 20S proteasome alpha subunit 6 0.014 0.3321 0.4871
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0141 0.3349 0.4911
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0153 0.3674 0.5387
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0053 0.0053
Giardia lamblia 20S proteasome alpha subunit 5 0.0153 0.3674 0.5387
Brugia malayi proteasome subunit alpha type 6 0.0154 0.3702 0.3702
Entamoeba histolytica proteasome regulatory subunit, putative 0.0032 0.0314 0.0461
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0154 0.3702 0.5429
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0193 0.4797 0.7035
Plasmodium falciparum proteasome subunit beta type-5 0.0265 0.6819 1
Giardia lamblia Proteasome subunit beta type 3 0.0134 0.3165 0.4641
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0032 0.0319 0.0468
Giardia lamblia 20S proteasome alpha subunit 3 0.014 0.3336 0.4892
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0193 0.4797 0.4797
Leishmania major proteasome beta 2 subunit, putative 0.0128 0.3001 0.4402
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0023 0.0053 0.0077
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0023 0.0052 0.0076
Leishmania major proteasome regulatory ATPase subunittcc1l8.3, putative 0.0021 0.0017 0.0025
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0023 0.0051 0.0074
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0032 0.0314 0.0461
Loa Loa (eye worm) hypothetical protein 0.0021 0.0017 0.0025
Loa Loa (eye worm) proteasome regulatory particle 0.0039 0.0498 0.0731
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0031 0.0273 0.0273
Plasmodium vivax proteasome subunit alpha type-4, putative 0.014 0.3336 0.4892
Loa Loa (eye worm) hypothetical protein 0.0031 0.0273 0.0401
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0128 0.3001 0.4402
Entamoeba histolytica proteasome regulatory subunit, putative 0.0039 0.0498 0.0731
Brugia malayi PCI domain containing protein 0.0032 0.0314 0.0314
Brugia malayi proteasome subunit beta type 2 0.0134 0.3165 0.3164
Echinococcus granulosus proteasome subunit beta type 7 0.0379 1 1
Leishmania major proteasome alpha 1 subunit, putative 0.014 0.3321 0.4871
Giardia lamblia 20S proteasome alpha subunit 4 0.0193 0.4797 0.7035
Loa Loa (eye worm) RPT-2 protein 0.0021 0.0017 0.0025
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0031 0.0273 0.0401
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0154 0.3702 0.5429
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0132 0.3115 0.4568
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0023 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0093 0.2013 0.2013
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0395 0.0395
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0039 0.0498 0.0498
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0039 0.0498 0.0731
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.014 0.3336 0.4892
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0265 0.6819 0.6819
Echinococcus granulosus proteasome subunit alpha type 6 0.0154 0.3702 0.3702
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0035 0.0395 0.058
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0036 0.0435 0.0639
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0017 0.0025
Plasmodium falciparum 26S protease regulatory subunit 6B, putative 0.0021 0.0017 0.0025
Brugia malayi proteasome subunit beta type 3 0.0134 0.3165 0.3164
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.014 0.3321 0.4871
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.014 0.3336 0.3336
Giardia lamblia Proteasome subunit beta type 2 0.0134 0.3165 0.4641
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0132 0.3115 0.4568
Entamoeba histolytica proteasome regulatory subunit, putative 0.0023 0.0051 0.0074
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0164 0.3981 0.3981
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0193 0.4797 0.7035
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0035 0.0395 0.058
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.0042 0.058 0.058
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0032 0.0319 0.0468
Toxoplasma gondii 26S protease regulatory subunit 4, putative 0.0021 0.0017 0.0025
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0146 0.3484 0.5109
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.0042 0.058 0.085
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0193 0.4797 0.4797
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Echinococcus granulosus proteasome prosome macropain 0.0265 0.6819 0.6819
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0319 0.0468
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0032 0.0319 0.0468
Leishmania major proteasome alpha 2 subunit, putative 0.0146 0.3484 0.5109
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0106 0.2377 0.5
Brugia malayi 20S proteasome alpha5 subunit 0.0153 0.3674 0.3674
Toxoplasma gondii PCI domain-containing protein 0.0039 0.0498 0.0731
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Brugia malayi Adhesion regulating molecule conserved region family protein 0.01 0.222 0.222
Leishmania major proteasome alpha 1 subunit, putative 0.0154 0.3702 0.5429
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0053 0.0053
Loa Loa (eye worm) proteasome subunit beta type 2 0.0134 0.3165 0.4641
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0023 0.0053 0.0053
Onchocerca volvulus 0.0021 0.0017 0.005
Trypanosoma cruzi proteasome regulatory ATPase subunit 2, putative 0.0021 0.0017 0.0025
Leishmania major proteasome beta 7 subunit, putative 0.0132 0.3115 0.4568
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0273 0.0401
Plasmodium vivax proteasome subunit beta type-4, putative 0.0132 0.3115 0.4568
Brugia malayi Proteasome A-type and B-type family protein 0.0265 0.6819 0.6819
Schistosoma mansoni hypothetical protein 0.0032 0.0314 0.0314
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0023 0.0053 0.0077
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0193 0.4797 0.7035
Leishmania major proteasome beta-1 subunit, putative 0.0141 0.3349 0.4911
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0036 0.0435 0.0639
Brugia malayi Proteasome subunit alpha type 1 0.0123 0.2839 0.2839
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0319 0.0319
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.01 0.222 0.3256
Loa Loa (eye worm) hypothetical protein 0.01 0.222 0.3256
Echinococcus multilocularis proteasome subunit alpha type 6 0.0154 0.3702 0.3702
Toxoplasma gondii proteasome 26S regulatory subunit 0.0022 0.0034 0.005
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0153 0.3674 0.5387
Plasmodium vivax proteasome subunit beta type-2, putative 0.0134 0.3165 0.4641
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0093 0.2013 0.2013
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0032 0.0319 0.0468
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0134 0.3165 0.3164
Loa Loa (eye worm) RPN-3 protein 0.0042 0.058 0.085
Leishmania major proteasome alpha 3 subunit, putative 0.014 0.3336 0.4892
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0146 0.3484 0.5109
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0153 0.3674 0.3674
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0142 0.3384 0.4963
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0032 0.0319 0.0319
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0035 0.0399 0.0585
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0134 0.3165 0.4641
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.014 0.3336 0.4892
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0142 0.3384 0.4963
Toxoplasma gondii SAC3/GANP family protein 0.0031 0.0273 0.0401
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0128 0.3001 0.4402
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0135 0.3191 0.3191
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0164 0.3981 0.5839
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0134 0.3165 0.4641
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0193 0.4797 0.7035
Echinococcus granulosus adhesion regulating molecule 1 0.01 0.222 0.222
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0023 0.0053 0.0077
Toxoplasma gondii proteasome subunit alpha type, putative 0.014 0.3336 0.4892
Echinococcus granulosus 26S proteasome regulatory subunit T3 0.0021 0.0017 0.0017
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0142 0.3384 0.3384
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0023 0.0051 0.0074
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0146 0.3484 0.5109
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0023 0.0053 0.0077
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0142 0.3384 0.4963
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0134 0.3165 0.4641
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0134 0.3165 0.3164
Toxoplasma gondii proteasome subunit 0.0141 0.3349 0.4911
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0035 0.0395 0.058
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0265 0.6819 1
Giardia lamblia Proteasome subunit beta type 1 0.0164 0.3981 0.5839
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0036 0.0435 0.0639
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.0042 0.058 0.058
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0128 0.3001 0.4402
Brugia malayi PCI domain containing protein 0.0035 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0228 0.5786 0.8485
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0154 0.3702 0.5429
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0141 0.3349 0.4911
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0035 0.0395 0.058
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0142 0.3384 0.4963
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0023 0.0053 0.0077
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0053 0.0077
Toxoplasma gondii proteasome subunit alpha1, putative 0.0154 0.3702 0.5429
Loa Loa (eye worm) PCI domain-containing protein 0.0032 0.0314 0.0461
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0106 0.2377 0.3486
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0134 0.3165 0.4641
Mycobacterium ulcerans proteasome PrcB 0.0265 0.6819 1
Giardia lamblia 20S proteasome alpha subunit 7 0.0142 0.3384 0.4963
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0017 0.0025
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0032 0.0319 0.0468
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.014 0.3336 0.4892
Leishmania major proteasome beta 5 subunit, putative 0.0265 0.6819 1
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0142 0.3384 0.3384
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0023 0.0053 0.0053
Giardia lamblia 26S protease regulatory subunit 6B 0.0021 0.0017 0.0025
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0154 0.3702 0.5429
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0154 0.3702 0.5429
Echinococcus granulosus Proteasome subunit alpha type 7 0.0193 0.4797 0.4797
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0193 0.4797 0.7035
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0036 0.0435 0.0435
Echinococcus granulosus Proteasome subunit alpha beta 0.0142 0.3384 0.3384
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0153 0.3674 0.5387
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0132 0.3115 0.3115
Plasmodium vivax proteasome subunit beta type-1, putative 0.0164 0.3981 0.5839
Plasmodium vivax proteasome subunit alpha type-1, putative 0.014 0.3321 0.4871
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0265 0.6819 1
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.01 0.222 0.222
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0265 0.6819 1
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0153 0.3674 0.5387
Brugia malayi 26S protease regulatory subunit 6A 0.0023 0.0053 0.0053
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0032 0.0319 0.0468
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Loa Loa (eye worm) hypothetical protein 0.0031 0.0273 0.0401
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0146 0.3484 0.5109
Brugia malayi proteasome subunit alpha type 4 0.0123 0.2854 0.2854
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0106 0.2377 0.3486
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0035 0.0399 0.0399
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0023 0.0053 0.0077
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0035 0.0395 0.058
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0031 0.0273 0.0401
Schistosoma mansoni 26S protease regulatory subunit 0.0021 0.0017 0.0017
Echinococcus granulosus proteasome subunit beta type 6 0.0141 0.3349 0.3349
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0128 0.3001 0.4402
Toxoplasma gondii proteasome regulatory subunit 0.0032 0.0319 0.0468
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.014 0.3321 0.4871
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0035 0.0399 0.0585
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0031 0.0273 0.0273
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0154 0.3702 0.5429
Plasmodium vivax proteasome subunit beta type-6, putative 0.0141 0.3349 0.4911
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0106 0.2377 0.2377
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0141 0.3349 0.4911
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0128 0.3001 0.4402
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0142 0.3384 0.4963
Trypanosoma brucei proteasome regulatory ATPase subunit 3 0.0021 0.0017 0.0025
Brugia malayi proteasome subunit alpha type 3 0.0142 0.3384 0.3384
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0153 0.3674 0.3674
Echinococcus granulosus proteasome 26s subunit subunit 4 atpase 0.0021 0.0017 0.0017
Leishmania major proteasome alpha 7 subunit, putative 0.0142 0.3384 0.4963
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0265 0.6819 1
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0064 0.1198 0.354
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0023 0.0053 0.0077
Leishmania major hypothetical protein, conserved 0.0052 0.0879 0.1289
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0093 0.2013 0.2013
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0039 0.0498 0.0731
Plasmodium vivax proteasome subunit beta type-3, putative 0.0134 0.3165 0.4641
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0023 0.0053 0.0053
Trypanosoma cruzi 20S proteasome subunit 0.0134 0.3165 0.4641
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0134 0.3165 0.4641
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0142 0.3384 0.4963
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0134 0.3165 0.4641
Brugia malayi Proteasome subunit alpha type 7-1 0.0193 0.4797 0.4797
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.014 0.3336 0.3336
Brugia malayi Proteasome A-type and B-type family protein 0.0141 0.3349 0.3349
Echinococcus multilocularis proteasome 26s subunit subunit 4 atpase 0.0021 0.0017 0.0017
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0265 0.6819 1
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0032 0.0319 0.0468
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.014 0.3321 0.3321
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0036 0.0435 0.0639
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.0042 0.058 0.058
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0132 0.3115 0.3115
Schistosoma mansoni 26S proteasome subunit S9 0.0039 0.0498 0.0498
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.014 0.3321 0.4871
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0032 0.0319 0.0319
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0031 0.0273 0.0273
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0036 0.0435 0.0639
Brugia malayi Probable 26S protease regulatory subunit 4 0.0021 0.0017 0.0017
Loa Loa (eye worm) proteasome subunit beta type 3 0.0134 0.3165 0.4641
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0134 0.3165 0.3164
Echinococcus multilocularis proteasome subunit alpha type 2 0.0146 0.3484 0.3484
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0021 0.0017 0.0025
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.014 0.3336 0.4892
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0035 0.0395 0.0395
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0106 0.2377 0.3486
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0153 0.3674 0.5387
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0017 0.0025
Brugia malayi proteasome subunit alpha type 2 0.0146 0.3484 0.3484
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0193 0.4797 0.4797
Plasmodium vivax 26S proteasome AAA-ATPase subunit RPT3, putative 0.0021 0.0017 0.0025
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0032 0.0319 0.0468
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0193 0.4797 0.7035
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0039 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0028 0.0208 0.0304
Toxoplasma gondii heat shock protein hslv, putative 0.0106 0.2377 0.3486
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0314 0.0461
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0123 0.2859 0.4193
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0035 0.0399 0.0585
Leishmania major proteasome beta 3 subunit, putative 0.0134 0.3165 0.4641
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0023 0.0053 0.0077
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0035 0.0399 0.0585
Schistosoma mansoni 26S protease regulatory subunit 6b 0.0021 0.0017 0.0017
Trichomonas vaginalis 26S proteasome subunit, putative 0.0032 0.0314 0.0461
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0032 0.0319 0.0468
Echinococcus multilocularis proteasome subunit beta type 6 0.0141 0.3349 0.3349
Trypanosoma brucei proteasome regulatory ATPase subunit 2 0.0021 0.0017 0.0025
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0032 0.0314 0.0461
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0265 0.6819 1
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0031 0.0273 0.0401
Schistosoma mansoni multiubiquitin binding protein S5a 0.0023 0.0051 0.0051
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0035 0.0395 0.0395
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0035 0.0395 0.058
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0193 0.4797 0.4797
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0153 0.3674 0.5387
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0132 0.3115 0.4568
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0164 0.3981 0.5839
Toxoplasma gondii peptidase, T1 family protein 0.0142 0.3384 0.4963
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0141 0.3349 0.3349
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0146 0.3484 0.5109
Schistosoma mansoni proteasome regulatory subunit-related 0.0035 0.0399 0.0399
Giardia lamblia 20S proteasome alpha subunit 1 0.0154 0.3702 0.5429
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0039 0.0498 0.0498
Toxoplasma gondii 26S proteasome regulatory subunit 6b, putative 0.0021 0.0017 0.0025
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0023 0.0051 0.0051
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0134 0.3165 0.3164
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0021 0.0017 0.0025
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0032 0.0319 0.0319
Giardia lamblia Hypothetical protein 0.0039 0.0498 0.0731
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0164 0.3981 0.5839
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0132 0.3115 0.4568
Trichomonas vaginalis 26S protease regulatory subunit 6A, putative 0.0021 0.0017 0.0025
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0032 0.0319 0.0319
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0134 0.3165 0.3164
Entamoeba histolytica proteasome regulatory subunit, putative 0.0035 0.0399 0.0585
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0146 0.3484 0.5109
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0031 0.0273 0.0401
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0031 0.0273 0.0401
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0036 0.0435 0.0639
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0265 0.6819 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0154 0.3702 0.5429
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0128 0.3001 0.4402
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0193 0.4797 0.7035
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0146 0.3484 0.3484
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0036 0.0435 0.0435
Leishmania major proteasome regulatory ATPase subunit 2, putative 0.0021 0.0017 0.0025
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0035 0.0399 0.0585
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0031 0.0273 0.0273
Toxoplasma gondii proteasome subunit beta type, putative 0.0265 0.6819 1
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0134 0.3165 0.4641

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.52 uM Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 mins by fluorescence analysis ChEMBL. 24900849
Kinact (binding) = 0.1 10'3/s Inhibition of immunoproteasome-20S subunit beta5i in human PBMC assessed as substrate hydrolysis using suc-LLVY-AMC as substrate measured for 120 mins by fluorescence analysis ChEMBL. 24900849
Ratio (binding) = 193.3 /M/s Ratio of Kinact to Ki for immunoproteasome-20S subunit beta5i in human PBMC using suc-LLVY-AMC as substrate measured for 120 mins by fluorescence analysis ChEMBL. 24900849

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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