Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Loa Loa (eye worm) | glutaminase 2 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Mycobacterium ulcerans | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Schistosoma mansoni | glutaminase | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Trichomonas vaginalis | glutaminase, putative | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Brugia malayi | glutaminase DH11.1 | Get druggable targets OG5_129245 | All targets in OG5_129245 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0426 | 0.7224 | 0.7224 |
Entamoeba histolytica | probable proteasome subunit beta type 2, putative | 0.0264 | 0.3546 | 0.3546 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0549 | 1 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.033 | 0.5044 | 0.5044 |
Loa Loa (eye worm) | glutaminase 2 | 0.033 | 0.5044 | 0.5044 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0549 | 1 | 1 |
Onchocerca volvulus | Notchless protein homolog | 0.0108 | 0 | 0.5 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0549 | 1 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0264 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0549 | 1 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0426 | 0.7224 | 0.7224 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0264 | 0.3546 | 0.3546 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0264 | 0.3546 | 0.3546 |
Echinococcus granulosus | proteasome prosome macropain | 0.0549 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 1 | 0.0426 | 0.7224 | 0.7224 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0426 | 0.7224 | 0.7224 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0426 | 0.7224 | 0.7224 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0549 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0426 | 0.7224 | 0.7224 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0549 | 1 | 1 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0549 | 1 | 1 |
Mycobacterium ulcerans | glutaminase | 0.033 | 0.5044 | 0.5044 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0264 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0264 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0264 | 0.3546 | 0.3546 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0549 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0426 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0426 | 0.7224 | 0.7224 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0264 | 0.3546 | 0.3546 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0108 | 0 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0426 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0549 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0549 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0426 | 0.7224 | 0.7224 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0264 | 0.3546 | 0.3546 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0426 | 0.7224 | 0.7224 |
Schistosoma mansoni | glutaminase | 0.033 | 0.5044 | 0.5044 |
Plasmodium vivax | proteasome subunit beta type-2, putative | 0.0264 | 0.3546 | 0.3546 |
Brugia malayi | glutaminase DH11.1 | 0.033 | 0.5044 | 0.5044 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0426 | 0.7224 | 0.7224 |
Giardia lamblia | Proteasome subunit beta type 2 | 0.0264 | 0.3546 | 0.3546 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0549 | 1 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0264 | 0.3546 | 0.3546 |
Mycobacterium ulcerans | proteasome PrcB | 0.0549 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.033 | 0.5044 | 0.5044 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0549 | 1 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0426 | 0.7224 | 0.7224 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0549 | 1 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0264 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0549 | 1 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0549 | 1 | 1 |
Plasmodium falciparum | proteasome subunit beta type-2, putative | 0.0264 | 0.3546 | 0.3546 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0264 | 0.3546 | 0.3546 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0264 | 0.3546 | 0.3546 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0426 | 0.7224 | 0.7224 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0264 | 0.3546 | 0.3546 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0426 | 0.7224 | 0.7224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.